@article{oai:nagoya.repo.nii.ac.jp:00007925,
 author = {JI, XIAOFEI and TAKAHASHI, NAGAHIDE and BRANKO, ALEKSIC and ISHIHARA, RYOKO and NAGAI, TAKU and MOURI, AKIHIRO and SAITO, SHINICHI and MAENO, NOBUHISA and INADA, TOSHIYA and OZAKI, NORIO},
 issue = {1-2},
 journal = {Nagoya journal of medical science},
 month = {Mar},
 note = {Genetic factors are thought to be involved in the development of treatment-resistant schizophrenia (TRS). Since several antipsychotic drugs inhibit the release of neurotransmitters via the serotonin receptors 3 (5-HT3), a dysfunction of this kind of receptor might be associated with the development of TRS. Thus, single-marker and haplotype analyses of the tag-single nucleotide polymorphisms (SNPs) of the 5-HT3B subunit gene (HTR3B) were performed in TRS (n = 101) and non-TRS (n = 244) patients. The deletion allele at the 3 bp-insertion/deletion polymorphism site (–100_–102delAAG) located in the putative HTR3B promoter region is significantly more frequent in the TRS group than the insertion allele by a single-marker comparison (p=0.031). In addition, luciferase promoter assays showed that the deletion allele exhibited significantly higher transcriptional activity than the insertion allele in COS7 cells (p<0.05). These results suggest that HTR3B is involved in the development of TRS in the Japanese population.},
 pages = {11--17},
 title = {AN ASSOCIATION BETWEEN SEROTONIN RECEPTOR 3B GENE (HTR3B) AND TREATMENT-RESISTANT SCHIZOPHRENIA (TRS) IN A JAPANESE POPULATION},
 volume = {70},
 year = {2008}
}