{"created":"2021-03-01T06:14:36.526696+00:00","id":7925,"links":{},"metadata":{"_buckets":{"deposit":"922e0584-55dc-48af-ba55-fc9444860627"},"_deposit":{"created_by":17,"id":"7925","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"7925"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00007925","sets":["499:508:509:955"]},"author_link":["22615","22616","22617","22618","22619","22620","22621","22622","22623","22624"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"17","bibliographicPageStart":"11","bibliographicVolumeNumber":"70","bibliographic_titles":[{"bibliographic_title":"Nagoya journal of medical science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Genetic factors are thought to be involved in the development of treatment-resistant schizophrenia (TRS). Since several antipsychotic drugs inhibit the release of neurotransmitters via the serotonin receptors 3 (5-HT3), a dysfunction of this kind of receptor might be associated with the development of TRS. Thus, single-marker and haplotype analyses of the tag-single nucleotide polymorphisms (SNPs) of the 5-HT3B subunit gene (HTR3B) were performed in TRS (n = 101) and non-TRS (n = 244) patients. The deletion allele at the 3 bp-insertion/deletion polymorphism site (–100_–102delAAG) located in the putative HTR3B promoter region is significantly more frequent in the TRS group than the insertion allele by a single-marker comparison (p=0.031). In addition, luciferase promoter assays showed that the deletion allele exhibited significantly higher transcriptional activity than the insertion allele in COS7 cells (p<0.05). These results suggest that HTR3B is involved in the development of TRS in the Japanese population.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/9647"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.70.1-2.11","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University School of Medicine","subitem_publisher_language":"en"}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_9_text_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_text_value":"application/pdf"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"JI, XIAOFEI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22615","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TAKAHASHI, NAGAHIDE","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22616","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"BRANKO, ALEKSIC","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22617","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ISHIHARA, RYOKO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22618","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NAGAI, TAKU","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22619","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MOURI, AKIHIRO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22620","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SAITO, SHINICHI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22621","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MAENO, NOBUHISA","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22622","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"INADA, TOSHIYA","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22623","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"OZAKI, NORIO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22624","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-19"}],"displaytype":"detail","filename":"p11-17_Xiaofei.pdf","filesize":[{"value":"241.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"p11-17_Xiaofei.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/7925/files/p11-17_Xiaofei.pdf"},"version_id":"20978caf-ecfe-41fe-aa49-839bdcf4a48f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"5-HT3B subunit","subitem_subject_scheme":"Other"},{"subitem_subject":"Polymorphism","subitem_subject_scheme":"Other"},{"subitem_subject":"Treatment-resistant","subitem_subject_scheme":"Other"},{"subitem_subject":"Luciferase assay","subitem_subject_scheme":"Other"},{"subitem_subject":"Schizophrenia","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"AN ASSOCIATION BETWEEN SEROTONIN RECEPTOR 3B GENE (HTR3B) AND TREATMENT-RESISTANT SCHIZOPHRENIA (TRS) IN A JAPANESE POPULATION","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"AN ASSOCIATION BETWEEN SEROTONIN RECEPTOR 3B GENE (HTR3B) AND TREATMENT-RESISTANT SCHIZOPHRENIA (TRS) IN A JAPANESE POPULATION","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["955"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2008-04-09"},"publish_date":"2008-04-09","publish_status":"0","recid":"7925","relation_version_is_last":true,"title":["AN ASSOCIATION BETWEEN SEROTONIN RECEPTOR 3B GENE (HTR3B) AND TREATMENT-RESISTANT SCHIZOPHRENIA (TRS) IN A JAPANESE POPULATION"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T06:34:13.277823+00:00"}