{"created":"2021-03-01T06:15:31.344408+00:00","id":8791,"links":{},"metadata":{"_buckets":{"deposit":"3eb7cfad-7ce4-4c78-98cd-9ddbc88a0a0f"},"_deposit":{"created_by":17,"id":"8791","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"8791"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00008791","sets":["499:508:509:1048"]},"author_link":["24725","24726","24727","24728","24729","24730","24731","24732","24733","24734"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"82","bibliographicPageStart":"73","bibliographicVolumeNumber":"70","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Molecular mechanisms for both morphogenesis and carcinogenesis have frequently overlapped, and similar signaling pathways are often involved in these processes. Yamamoto et al. identified a novel protein that induces head formation in Xenopus (Yamamoto et al. Cell, 120, 223-225, 2005). This new protein, named Shisa, plays unique roles in head formation by suppressing the maturation processes of receptors for Wnt and FGF at the endoplasmic reticulum. Here, we have identified a human homologue of the shisa gene (hu-shisa-2), and analyzed its expression in various human cancer cell lines by real-time reverse transcription polymerase chain reaction. High levels of mRNA expression were observed in some neuroectoderm-derived human cancer cell lines and small cell lung cancer cell lines. Intracellular localization of hu-Shisa-2 protein was also analyzed, indicating that it is present in the endoplasmic reticulum. Over-expression of hu-Shisa-2 resulted in increased cell growth and invasion, suggesting that hu-Shisa-2 is involved in the evolution and/or progression of human cancers.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/10543"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.70.3-4.73","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University School of Medicine","subitem_publisher_language":"en"}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_9_text_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_text_value":"application/pdf"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ZHU, YINGSONG","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24725","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TSUCHIDA, AKIKO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24726","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YAMAMOTO, AKIHITO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24727","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"FURUKAWA, KEIKO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24728","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TAJIMA, ORIE","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24729","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TOKUDA, NORIYO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24730","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"AIZAWA, SHINICHI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24731","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"URANO, TAKESHI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24732","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KADOMATSU, KENJI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24733","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"FURUKAWA, KOICHI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24734","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-19"}],"displaytype":"detail","filename":"p073-082_Zhu.pdf","filesize":[{"value":"506.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"p073-082_Zhu.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/8791/files/p073-082_Zhu.pdf"},"version_id":"8acc4faf-591e-4518-aff7-baa7699381cf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Head","subitem_subject_scheme":"Other"},{"subitem_subject":"Wnt","subitem_subject_scheme":"Other"},{"subitem_subject":"Frizzled","subitem_subject_scheme":"Other"},{"subitem_subject":"Cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"Xenopus","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"EXPRESSION AND ROLES OF A XENOPUS　HEAD-FORMING GENE HOMOLOGUE　IN HUMAN CANCER CELL LINES","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"EXPRESSION AND ROLES OF A XENOPUS　HEAD-FORMING GENE HOMOLOGUE　IN HUMAN CANCER CELL LINES","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["1048"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2008-09-22"},"publish_date":"2008-09-22","publish_status":"0","recid":"8791","relation_version_is_last":true,"title":["EXPRESSION AND ROLES OF A XENOPUS　HEAD-FORMING GENE HOMOLOGUE　IN HUMAN CANCER CELL LINES"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T06:34:28.307485+00:00"}