{"_buckets": {"deposit": "d7a104cd-85af-47e2-ae1d-d1427c8b1abe"}, "_deposit": {"id": "8921", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "8921"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00008921", "sets": ["961"]}, "author_link": ["25065", "25066"], "item_12_alternative_title_19": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "染色体分析、HbF 免疫染色、p53 免疫染色の組み合わせは骨髄異形成症候群の不応性貧血と再生不良性貧血の鑑別診断に有用である", "subitem_alternative_title_language": "ja"}]}, "item_12_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-09-30", "bibliographicIssueDateType": "Issued"}}]}, "item_12_date_granted_64": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2008-09-30"}]}, "item_12_degree_grantor_62": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_language": "ja", "subitem_degreegrantor_name": "名古屋大学"}, {"subitem_degreegrantor_language": "en", "subitem_degreegrantor_name": "NAGOYA University"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "13901", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_12_degree_name_61": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医療技術学)", "subitem_degreename_language": "ja"}]}, "item_12_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "P53 mutation has been reported in various solid tumors, acute leukemia and myelodysplastic syndrome (MDS). However, the diagnostic significance of p53 in MDS remains to be determined. We examined p53 mutation and immunostaining of the same patients, since there have been few reports of simultaneous analysis of these markers. Seven p53 mutations were observed among 37 MDS and 11 cases of overt leukemia transformed from MDS (MDS-OL). Mutated p53 mainly observed in high-risk MDS showed more intense p53 staining than those of MDS cases with wild-type p53 overexpression. Aplastic anemia (AA) showed no p53 staining. The percentage of p53 staining of MDS (71%) was higher than that of mutated p53 cases (11%) but did not reach 100% of MDS cases studied. Therefore, we tried to differentiate MDS, especially RA and AA using a combination of p53 immunostaining, HbF immunostaining and chromosome abnormality, because Hemoglobin F (HbF) of erythroblasts was reportedly observed in MDS refractory anemia (RA) but not in AA. Most MDS/MDS-OL (47/48) showed at least one positive marker, whereas 11 AA cases proved totally negative except for two positive HbF cases. Our results suggest that the combination of these three markers is useful to discriminate MDS from AA.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_12_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "名古屋大学博士学位論文 学位の種類:博士(医療技術学) (課程) 学位授与年月日:平成20年9月30日", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_12_dissertation_number_65": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲第8124号"}]}, "item_12_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/10682"}]}, "item_12_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_12_text_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_text_value": "application/pdf"}]}, "item_12_text_63": {"attribute_name": "学位授与年度", "attribute_value_mlt": [{"subitem_text_value": "2008"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "岩崎, 卓識", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "25065", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iwasaki, Takashi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "25066", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "k8124_thesis.pdf", "filesize": [{"value": "4.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 4200000.0, "url": {"label": "k8124_thesis.pdf", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/8921/files/k8124_thesis.pdf"}, "version_id": "b0df21ef-175a-47ff-842c-042d59d1684f"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "aplastic anemia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "differential diagnosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "HbF", "subitem_subject_scheme": "Other"}, {"subitem_subject": "immunostaining", "subitem_subject_scheme": "Other"}, {"subitem_subject": "karyotype analysis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "myelodysplastic syndrome", "subitem_subject_scheme": "Other"}, {"subitem_subject": "p53 protein", "subitem_subject_scheme": "Other"}, {"subitem_subject": "p53 mutation study", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "The combination of karyotype analysis, HbF and p53 immunostaining is useful for the differential diagnosis between refractory anemia and aplastic anemia.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "The combination of karyotype analysis, HbF and p53 immunostaining is useful for the differential diagnosis between refractory anemia and aplastic anemia.", "subitem_title_language": "en"}]}, "item_type_id": "12", "owner": "1", "path": ["961"], "permalink_uri": "http://hdl.handle.net/2237/10682", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-12-01"}, "publish_date": "2008-12-01", "publish_status": "0", "recid": "8921", "relation": {}, "relation_version_is_last": true, "title": ["The combination of karyotype analysis, HbF and p53 immunostaining is useful for the differential diagnosis between refractory anemia and aplastic anemia."], "weko_shared_id": -1}