@article{oai:nagoya.repo.nii.ac.jp:00009539,
 author = {INAGAKI-TACHIBANA, EIKO and TSUKAHARA, TAKAMITSU and KAJI, KAZUHIKO and EGUCHI, RYOJI and KANAZAWA, HIROAKI and HAYASHI, HISAYOSHI and SUZUKI, YUICHI},
 issue = {1-2},
 journal = {Nagoya Journal of Medical Science},
 month = {Feb},
 note = {A mouse jejunum, when incubated in vitro in Ussing chambers, was found to exhibit morphological deterioration of the villi with denudation of the epithelia (J Nutr Sci Vitaminol, 51: 406, 2005). Our study examined the involvement of apoptosis in an intestinal injury model by a DNA ladder assay and terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay. Electrophoresis of mucosal DNA revealed ladders, indicating the occurrence of DNA fragmentation. Cells with TUNEL-positive nuclei were detected among the villus epithelial cells (enterocytes), whereas they are rarely seen among crypt epithelial cells. These features were evident within 1 h after the start of incubation. Apoptotic death of the enterocytes was thus involved in the destruction of villi when incubated in Ussing chambers.},
 pages = {11--18},
 title = {INVOLVEMENT OF DNA FRAGMENTATION OF ENTEROCYTES IN MUCOSAL INJURY TO A MOUSE JEJUNUM INCUBATED IN USSING CHAMBERS},
 volume = {71},
 year = {2009}
}