{"created":"2021-03-01T06:16:27.184627+00:00","id":9671,"links":{},"metadata":{"_buckets":{"deposit":"36da9e75-a215-4fd7-a5c0-e4c75feb15be"},"_deposit":{"id":"9671","owners":[],"pid":{"revision_id":0,"type":"depid","value":"9671"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00009671","sets":["499:960:961"]},"author_link":["29308","29309"],"item_12_alternative_title_19":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"周期的伸張刺激はAkt/mTOR/p70S6K 経路を介して除神経によるヒラメ筋萎縮を抑制する","subitem_alternative_title_language":"ja"}]},"item_12_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03-25","bibliographicIssueDateType":"Issued"}}]},"item_12_date_granted_64":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2009-03-25"}]},"item_12_degree_grantor_62":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"名古屋大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"NAGOYA University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"13901","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_12_degree_name_61":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医療技術学)","subitem_degreename_language":"ja"}]},"item_12_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This study was conducted to examine whether stretch-related mechanical loading on skeletal muscle can suppress denervation-induced muscle atrophy, and if so, to depict the underlying molecular mechanism. Denervated rat soleus muscle was repetitively stretched (every 5 sec for 15 min/day) for 2 weeks. Histochemical analysis showed that the cross-sectional area of denervated soleus muscle fibers with repetitive stretching was significantly larger than that of control denervated muscle (p<0.05). We then examined the involvement of the Akt/mammalian target of the rapamycin (mTOR) cascade in the suppressive effects of repetitive stretching on muscle atrophy. Repetitive stretching significantly increased the Akt, p70S6K and 4E-BP1 phosphorylation in denervated soleus muscle compared to controls (p<0.05). Furthermore, repetitive stretching-induced suppression of muscle atrophy was fully inhibited by rapamycin, a potent inhibitor of mTOR. These results indicate that denervation-induced muscle atrophy is significantly suppressed by stretch-related mechanical loading of the muscle through upregulation of the Akt/mTOR signal pathway.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_12_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"名古屋大学博士学位論文 学位の種類:博士（医療技術学）（課程）学位授与年月日:平成21年3月25日","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_12_dissertation_number_65":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第8251号"}]},"item_12_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/11470"}]},"item_12_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_12_text_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_text_value":"application/pdf"}]},"item_12_text_63":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_text_value":"2008"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"縣, 信秀","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"29308","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Agata, Nobuhide","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"29309","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-20"}],"displaytype":"detail","filename":"k8251_thesis.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"k8251_thesis.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/9671/files/k8251_thesis.pdf"},"version_id":"8f4b023e-b243-49fe-80d7-18444ae34c09"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Akt","subitem_subject_scheme":"Other"},{"subitem_subject":"muscle atrophy","subitem_subject_scheme":"Other"},{"subitem_subject":"p70S6K","subitem_subject_scheme":"Other"},{"subitem_subject":"rapamycin","subitem_subject_scheme":"Other"},{"subitem_subject":"repetitive stretch","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Repetitive Stretching Prevents Muscle Atrophy in Denervated Soleus Muscle via Akt/mTOR/p70S6K Pathways","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Repetitive Stretching Prevents Muscle Atrophy in Denervated Soleus Muscle via Akt/mTOR/p70S6K Pathways","subitem_title_language":"en"}]},"item_type_id":"12","owner":"1","path":["961"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-04-16"},"publish_date":"2009-04-16","publish_status":"0","recid":"9671","relation_version_is_last":true,"title":["Repetitive Stretching Prevents Muscle Atrophy in Denervated Soleus Muscle via Akt/mTOR/p70S6K Pathways"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-01-16T03:55:25.014941+00:00"}