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Increased metabolite production by deletion of an HDA1-type histone deacetylase in the phytopathogenic fungi, Magnaporthe oryzae (Pyricularia oryzae) and Fusarium asiaticum
http://hdl.handle.net/2237/00028583
http://hdl.handle.net/2237/00028583e9e4acb6-63db-40e0-8bc7-8bb82987ff3a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Increased_metabolite_production (2.5 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-09-27 | |||||
| タイトル | ||||||
| タイトル | Increased metabolite production by deletion of an HDA1-type histone deacetylase in the phytopathogenic fungi, Magnaporthe oryzae (Pyricularia oryzae) and Fusarium asiaticum | |||||
| 言語 | en | |||||
| 著者 |
Maeda, K.
× Maeda, K.× Izawa, M.× Nakajima, Y.× Jin, Q.× Hirose, T.× Nakamura, T.× Koshino, H.× Kanamaru, K.× Ohsato, S.× Kamakura, T.× Kobayashi, T.× Yoshida, M.× Kimura, M. |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | This is the peer reviewed version of the following article: [Maeda, K. , Izawa, M. , Nakajima, Y. , Jin, Q. , Hirose, T. , Nakamura, T. , Koshino, H. , Kanamaru, K. , Ohsato, S. , Kamakura, T. , Kobayashi, T. , Yoshida, M. and Kimura, M. (2017), Increased metabolite production by deletion of an HDA1‐type histone deacetylase in the phytopathogenic fungi, Magnaporthe oryzae (Pyricularia oryzae) and Fusarium asiaticum. Lett Appl Microbiol, 65: 446-452. doi:10.1111/lam.12797], which has been published in final form at [https://doi.org/10.1111/lam.12797]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | biosynthesis gene cluster | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | fungal natural products | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | histone acetylation/deacetylation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | rice blast fungus | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | wheat scab fungus | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Histone deacetylases (HDACs) play an important role in the regulation of chromatin structure and gene expression. We found that dark pigmentation of Magnaporthe oryzae (anamorph Pyricularia oryzae) ΔMohda1, a mutant strain in which an orthologue of the yeast HDA1 was disrupted by double cross‐over homologous recombination, was significantly stimulated in liquid culture. Analysis of metabolites in a ΔMohda1 mutant culture revealed that the accumulation of shunt products of the 1,8‐dihydroxynaphthalene melanin and ergosterol pathways were significantly enhanced compared to the wild‐type strain. Northern blot analysis of the ΔMohda1 mutant revealed transcriptional activation of three melanin genes that are dispersed throughout the genome of M. oryzae. The effect of deletion of the yeast HDA1 orthologue was also observed in Fusarium asiaticum from the Fusarium graminearum species complex; the HDF2 deletion mutant produced increased levels of nivalenol‐type trichothecenes. These results suggest that histone modification via HDA1‐type HDAC regulates the production of natural products in filamentous fungi. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ファイル公開：2018-11-01 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Wiley | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1111/lam.12797 | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0266-8254 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 1472-765X | |||||
| 書誌情報 |
en : Letters in Applied Microbiology 巻 65, 号 5, p. 446-452, 発行日 2017-11 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
