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Evaluation of intra-tumoral blood feeding to predict the effect of induction therapy in patients with locally advanced lung cancer
https://doi.org/10.18999/nagjms.81.2.291
https://doi.org/10.18999/nagjms.81.2.2912ae0d10e-44e5-4b98-886c-676205e367c6
名前 / ファイル | ライセンス | アクション |
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13_Kawaguchi.pdf (4.6 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-06-13 | |||||
タイトル | ||||||
タイトル | Evaluation of intra-tumoral blood feeding to predict the effect of induction therapy in patients with locally advanced lung cancer | |||||
言語 | en | |||||
著者 |
Kawaguchi, Koji
× Kawaguchi, Koji× Fukui, Takayuki× Goto, Masaki× Nakamura, Shota× Hakiri, Shuhei× Ozeki, Naoki× Kato, Taketo× Mori, Shunsuke× Hashimoto, Kumiko× Iwano, Shingo× Yokoi, Kohei |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報Resource | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
権利情報 | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | locally advanced lung cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | induction therapy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | blood supply | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | tumor vascularity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dynamic CT | |||||
抄録 | ||||||
内容記述 | There is little known about predictors of the effects of induction therapy in locally advanced lung cancer, including superior sulcus tumors. We analyzed whether intra-tumoral blood feeding could predict a pathologic complete response (pCR). Patients who underwent induction therapy followed by surgery for locally advanced lung cancer were retrospectively reviewed. The intra-tumoral blood feeding was defined by the CT value (HU, Hounsfield unit), which was calculated by subtracting the non-enhanced value from the contrast-enhanced value (divided into the early and delayed phase) at the maximum diameter of the tumor on dynamic CT. The cases were classified, according to the efficacy of induction therapy, into the pCR and residual tumor (pRT) group. There were 38 cases of T3 and 12 of T4; the induction therapy consisted of chemoradiotherapy in 39 patients, chemotherapy in 6, and radiotherapy in 5. A pCR was obtained in 15 (30%) patients. The mean CT values of the early and delayed phases in the pCR group were 14.8 and 30.7 HU, while those in the pRT were 15.3 and 32.2 HU, respectively. A logistic regression analysis revealed that a smaller tumor size (< 42 mm) was a non-significant predictor of a pCR (p = 0.09); the maximum standardized uptake value on FDG-PET and the CT values on the early and delayed phases of dynamic CT were not associated with the achievement of a pCR. In conclusion, intra-tumoral blood feeding of the locally advanced lung cancer did not predict the effects of induction therapy, whereas smaller sized tumors tended to show a better response. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Nagoya University Graduate School of Medicine, School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.81.2.291 | |||||
ID登録タイプ | JaLC | |||||
関連情報 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | URI | |||||
関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/812.html | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
en : Nagoya Journal of Medical Science 巻 81, 号 2, p. 291-301, 発行日 2019-05 |
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著者版フラグ | ||||||
値 | publisher |