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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 81(2)

Evaluation of intra-tumoral blood feeding to predict the effect of induction therapy in patients with locally advanced lung cancer

https://doi.org/10.18999/nagjms.81.2.291
https://doi.org/10.18999/nagjms.81.2.291
2ae0d10e-44e5-4b98-886c-676205e367c6
名前 / ファイル ライセンス アクション
13_Kawaguchi.pdf 13_Kawaguchi.pdf (4.6 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2019-06-13
タイトル
タイトル Evaluation of intra-tumoral blood feeding to predict the effect of induction therapy in patients with locally advanced lung cancer
著者 Kawaguchi, Koji

× Kawaguchi, Koji

WEKO 92105

Kawaguchi, Koji

Search repository
Fukui, Takayuki

× Fukui, Takayuki

WEKO 92106

Fukui, Takayuki

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Goto, Masaki

× Goto, Masaki

WEKO 92107

Goto, Masaki

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Nakamura, Shota

× Nakamura, Shota

WEKO 92108

Nakamura, Shota

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Hakiri, Shuhei

× Hakiri, Shuhei

WEKO 92109

Hakiri, Shuhei

Search repository
Ozeki, Naoki

× Ozeki, Naoki

WEKO 92110

Ozeki, Naoki

Search repository
Kato, Taketo

× Kato, Taketo

WEKO 92111

Kato, Taketo

Search repository
Mori, Shunsuke

× Mori, Shunsuke

WEKO 92112

Mori, Shunsuke

Search repository
Hashimoto, Kumiko

× Hashimoto, Kumiko

WEKO 92113

Hashimoto, Kumiko

Search repository
Iwano, Shingo

× Iwano, Shingo

WEKO 92114

Iwano, Shingo

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Yokoi, Kohei

× Yokoi, Kohei

WEKO 92115

Yokoi, Kohei

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キーワード
主題Scheme Other
主題 locally advanced lung cancer
キーワード
主題Scheme Other
主題 induction therapy
キーワード
主題Scheme Other
主題 blood supply
キーワード
主題Scheme Other
主題 tumor vascularity
キーワード
主題Scheme Other
主題 dynamic CT
抄録
内容記述 There is little known about predictors of the effects of induction therapy in locally advanced lung cancer, including superior sulcus tumors. We analyzed whether intra-tumoral blood feeding could predict a pathologic complete response (pCR). Patients who underwent induction therapy followed by surgery for locally advanced lung cancer were retrospectively reviewed. The intra-tumoral blood feeding was defined by the CT value (HU, Hounsfield unit), which was calculated by subtracting the non-enhanced value from the contrast-enhanced value (divided into the early and delayed phase) at the maximum diameter of the tumor on dynamic CT. The cases were classified, according to the efficacy of induction therapy, into the pCR and residual tumor (pRT) group. There were 38 cases of T3 and 12 of T4; the induction therapy consisted of chemoradiotherapy in 39 patients, chemotherapy in 6, and radiotherapy in 5. A pCR was obtained in 15 (30%) patients. The mean CT values of the early and delayed phases in the pCR group were 14.8 and 30.7 HU, while those in the pRT were 15.3 and 32.2 HU, respectively. A logistic regression analysis revealed that a smaller tumor size (< 42 mm) was a non-significant predictor of a pCR (p = 0.09); the maximum standardized uptake value on FDG-PET and the CT values on the early and delayed phases of dynamic CT were not associated with the achievement of a pCR. In conclusion, intra-tumoral blood feeding of the locally advanced lung cancer did not predict the effects of induction therapy, whereas smaller sized tumors tended to show a better response.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.81.2.291
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/812.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 81, 号 2, p. 291-301, 発行日 2019-05
著者版フラグ
値 publisher
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