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Efficient induction of osteogenic and chondrogenic progenitors and myogenic progenitors from mouse ES cells in chemically defined medium
http://hdl.handle.net/2237/12106
http://hdl.handle.net/2237/12106d911da51-a1b5-4cc3-9487-833d08be2c8a
名前 / ファイル | ライセンス | アクション |
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IEEEd.pdf (2.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-08-27 | |||||
タイトル | ||||||
タイトル | Efficient induction of osteogenic and chondrogenic progenitors and myogenic progenitors from mouse ES cells in chemically defined medium | |||||
言語 | en | |||||
著者 |
Sakurai, Hidetoshi
× Sakurai, Hidetoshi× Inami, Yuta× Nishio, Naomi× Yoshikai, Tohru× Isobe, Ken-Ichi |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | Copyright © 2008 IEEE. Reprinted from International Symposium on Micro-NanoMechatronics and Human Science, 2008. MHS 2008, p.487-490. This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of Nagoya University’s products or services. Internal or personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution must be obtained from the IEEE by writing to pubs-permissions@ieee.org. |
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抄録 | ||||||
内容記述 | Embryonic stem (ES) cells and induced pluripotent stem (iPS) cells represent a renewable cellular resources for regenerative therapies. Here, we try to differentiate ES cells to paraxial mesodermal progenitors cells (PMPs), which give rise to osteogenic and chondrogenic progenitors and myogenic progenitors without fetal calf serum. Here, we demonstrate the methods for inducing paraxial mesodermal progenitors efficiently by treatment of BMP4 using PDGFR-a and ECD as markers for purifying them. The BMP4 induced PMPs exhibit fine potentials of differentiation to osto-and chondro-genic cells. Furthermore, early extraction of BMP4 and additional LiCl treatment promote the differentiation of myogenic progenitor cells. Further addition of IGF-1, bFGF and HGF induced the differentiation of PMPs to myocytes in vitro. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | IEEE | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1109/MHS.2008.4752501 | |||||
書誌情報 |
en : International Symposium on Micro-NanoMechatronics and Human Science (MHS 2008) p. 487-490, 発行日 2008-11 |
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著者版フラグ | ||||||
値 | author | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/12106 | |||||
識別子タイプ | HDL |