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Goshajinkigan (Chinese Herbal Medicine Niu-Che-Sen-Qi-Wan) Improves Insulin Resistance in Diabetic Rats via the Nitric Oxide Pathway
https://doi.org/10.18999/nagjms.72.1-2.35
https://doi.org/10.18999/nagjms.72.1-2.35d8638c61-3fb6-479d-b2c5-f7d44fbb49b0
名前 / ファイル | ライセンス | アクション |
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p035-042_Hu.pdf (105.1 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2010-03-11 | |||||
タイトル | ||||||
タイトル | Goshajinkigan (Chinese Herbal Medicine Niu-Che-Sen-Qi-Wan) Improves Insulin Resistance in Diabetic Rats via the Nitric Oxide Pathway | |||||
言語 | en | |||||
著者 |
Hu, Xiaochen
× Hu, Xiaochen× Sato, Juichi× Bajotto, Gustavo× Khookhor, Oyun× Ohsawa, Isao× Oshida, Yoshiharu× Sato, Yuzo |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Kampo medicine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Goshajinkigan | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Insulin resistance | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Diabetes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Nitric oxide | |||||
抄録 | ||||||
内容記述 | Goshajinkigan (GJG), an aqueous extract of a combination of 10 herbal medicines, is widely used for the treatment of diabetic neuropathy in Japan. In this study, the effect of GJG on insulin-induced glucose disposal in normal and streptozotocin (STZ) diabetic rats was analyzed using the euglycemic clamp technique. Male Wistar rats, aged 9 weeks, were randomly assigned to six groups: group NS, normal rats receiving saline; group NG, normal rats receiving GJG (800 mg·kg–1·day–1, p.o.); group NGL, normal rats receiving GJG + NG-monomethyl-L-arginine (L-NMMA, 1 mg·kg–1·min–1, i.v.); group DS, diabetic rats receiving saline; group DG, diabetic rats receiving GJG; group DGL, diabetic rats receiving GJG + L-NMMA. After daily oral administrations of saline or GJG for one week, euglycemic clamp experiments were performed. The metabolic clearance rates of glucose (MCR) in the DS, DG, and DGL groups (8.7 ± 2.9, 18.2 ± 2.5, and 8.1 ± 1.8 ml·kg–1·min–1, respectively) were significantly lower than those in the NS, NG, and NGL groups (24.1 ± 4.5, 24.5 ± 3.1, and 22.2 ± 2.1 ml·kg–1·min–1, respectively). In addition, the MCR in the DG group was significantly higher than that in the DS and DGL groups, while no significant difference was detected among the NS, NG, and NGL groups. Furthermore, the amelioration of insulin resistance by GJG in diabetic rats was hampered by L-NMMA infusion. These results suggest that daily GJG administrations ameliorate insulin resistance in STZ-diabetic rats, and that the nitric oxide pathway may mediate the effect of GJG. |
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言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Nagoya University School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.72.1-2.35 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0027-7622 | |||||
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収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
en : Nagoya Journal of Medical Science 巻 72, 号 1-2, p. 35-42, 発行日 2010-02 |
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application/pdf | ||||||
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値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/12907 | |||||
識別子タイプ | HDL |