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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 72(1-2)

Goshajinkigan (Chinese Herbal Medicine Niu-Che-Sen-Qi-Wan) Improves Insulin Resistance in Diabetic Rats via the Nitric Oxide Pathway

https://doi.org/10.18999/nagjms.72.1-2.35
https://doi.org/10.18999/nagjms.72.1-2.35
d8638c61-3fb6-479d-b2c5-f7d44fbb49b0
名前 / ファイル ライセンス アクション
p035-042_Hu.pdf p035-042_Hu.pdf (105.1 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2010-03-11
タイトル
タイトル Goshajinkigan (Chinese Herbal Medicine Niu-Che-Sen-Qi-Wan) Improves Insulin Resistance in Diabetic Rats via the Nitric Oxide Pathway
著者 Hu, Xiaochen

× Hu, Xiaochen

WEKO 33481

Hu, Xiaochen

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Sato, Juichi

× Sato, Juichi

WEKO 33482

Sato, Juichi

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Bajotto, Gustavo

× Bajotto, Gustavo

WEKO 33483

Bajotto, Gustavo

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Khookhor, Oyun

× Khookhor, Oyun

WEKO 33484

Khookhor, Oyun

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Ohsawa, Isao

× Ohsawa, Isao

WEKO 33485

Ohsawa, Isao

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Oshida, Yoshiharu

× Oshida, Yoshiharu

WEKO 33486

Oshida, Yoshiharu

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Sato, Yuzo

× Sato, Yuzo

WEKO 33487

Sato, Yuzo

Search repository
キーワード
主題Scheme Other
主題 Kampo medicine
キーワード
主題Scheme Other
主題 Goshajinkigan
キーワード
主題Scheme Other
主題 Insulin resistance
キーワード
主題Scheme Other
主題 Diabetes
キーワード
主題Scheme Other
主題 Nitric oxide
抄録
内容記述 Goshajinkigan (GJG), an aqueous extract of a combination of 10 herbal medicines, is widely used for the treatment of diabetic neuropathy in Japan. In this study, the effect of GJG on insulin-induced glucose disposal in normal and streptozotocin (STZ) diabetic rats was analyzed using the euglycemic clamp technique. Male Wistar rats, aged 9 weeks, were randomly assigned to six groups: group NS, normal rats receiving saline; group NG, normal rats receiving GJG (800 mg·kg–1·day–1, p.o.); group NGL, normal rats receiving GJG + NG-monomethyl-L-arginine (L-NMMA, 1 mg·kg–1·min–1, i.v.); group DS, diabetic rats receiving saline; group DG, diabetic rats receiving GJG; group DGL, diabetic rats receiving GJG +
L-NMMA. After daily oral administrations of saline or GJG for one week, euglycemic clamp experiments were performed. The metabolic clearance rates of glucose (MCR) in the DS, DG, and DGL groups (8.7 ± 2.9, 18.2 ± 2.5, and 8.1 ± 1.8 ml·kg–1·min–1, respectively) were significantly lower than those in the NS, NG, and NGL groups (24.1 ± 4.5, 24.5 ± 3.1, and 22.2 ± 2.1 ml·kg–1·min–1, respectively). In addition, the
MCR in the DG group was significantly higher than that in the DS and DGL groups, while no significant difference was detected among the NS, NG, and NGL groups. Furthermore, the amelioration of insulin resistance by GJG in diabetic rats was hampered by L-NMMA infusion. These results suggest that daily GJG administrations ameliorate insulin resistance in STZ-diabetic rats, and that the nitric oxide pathway may mediate the effect of GJG.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.72.1-2.35
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 72, 号 1-2, p. 35-42, 発行日 2010-02
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/12907
識別子タイプ HDL
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