{"_buckets": {"deposit": "c7fb5e74-cb00-42ad-b605-553847b339df"}, "_deposit": {"id": "11045", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "11045"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00011045", "sets": ["1196"]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-02", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1-2", "bibliographicPageEnd": "42", "bibliographicPageStart": "35", "bibliographicVolumeNumber": "72", "bibliographic_titles": [{"bibliographic_title": "Nagoya Journal of Medical Science"}]}]}, "item_9_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Goshajinkigan (GJG), an aqueous extract of a combination of 10 herbal medicines, is widely used for the treatment of diabetic neuropathy in Japan. In this study, the effect of GJG on insulin-induced glucose disposal in normal and streptozotocin (STZ) diabetic rats was analyzed using the euglycemic clamp technique. Male Wistar rats, aged 9 weeks, were randomly assigned to six groups: group NS, normal rats receiving saline; group NG, normal rats receiving GJG (800 mg·kg–1·day–1, p.o.); group NGL, normal rats receiving GJG + NG-monomethyl-L-arginine (L-NMMA, 1 mg·kg–1·min–1, i.v.); group DS, diabetic rats receiving saline; group DG, diabetic rats receiving GJG; group DGL, diabetic rats receiving GJG +\nL-NMMA. After daily oral administrations of saline or GJG for one week, euglycemic clamp experiments were performed. The metabolic clearance rates of glucose (MCR) in the DS, DG, and DGL groups (8.7 ± 2.9, 18.2 ± 2.5, and 8.1 ± 1.8 ml·kg–1·min–1, respectively) were significantly lower than those in the NS, NG, and NGL groups (24.1 ± 4.5, 24.5 ± 3.1, and 22.2 ± 2.1 ml·kg–1·min–1, respectively). In addition, the\nMCR in the DG group was significantly higher than that in the DS and DGL groups, while no  significant difference was detected among the NS, NG, and NGL groups. Furthermore, the amelioration of insulin resistance by GJG in diabetic rats was hampered by L-NMMA infusion. These results suggest that daily GJG administrations ameliorate insulin resistance in STZ-diabetic rats, and that the nitric oxide pathway may mediate the effect of GJG.", "subitem_description_type": "Abstract"}]}, "item_9_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/12907"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.72.1-2.35", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University School of Medicine"}]}, "item_9_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_7": {"attribute_name": "ISSN（print）", "attribute_value_mlt": [{"subitem_source_identifier": "0027-7622", "subitem_source_identifier_type": "ISSN"}]}, "item_9_text_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_text_value": "application/pdf"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hu, Xiaochen"}], "nameIdentifiers": [{"nameIdentifier": "33481", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sato, Juichi"}], "nameIdentifiers": [{"nameIdentifier": "33482", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Bajotto, Gustavo"}], "nameIdentifiers": [{"nameIdentifier": "33483", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Khookhor, Oyun"}], "nameIdentifiers": [{"nameIdentifier": "33484", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohsawa, Isao"}], "nameIdentifiers": [{"nameIdentifier": "33485", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oshida, Yoshiharu"}], "nameIdentifiers": [{"nameIdentifier": "33486", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sato, Yuzo"}], "nameIdentifiers": [{"nameIdentifier": "33487", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "p035-042_Hu.pdf", "filesize": [{"value": "105.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 105100.0, "url": {"label": "p035-042_Hu.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/11045/files/p035-042_Hu.pdf"}, "version_id": "a545abd9-4535-4c53-9fda-15e23241b274"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Kampo medicine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Goshajinkigan", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Insulin resistance", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Diabetes", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Nitric oxide", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Goshajinkigan (Chinese Herbal Medicine Niu-Che-Sen-Qi-Wan) Improves Insulin Resistance in Diabetic Rats via the Nitric Oxide Pathway", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Goshajinkigan (Chinese Herbal Medicine Niu-Che-Sen-Qi-Wan) Improves Insulin Resistance in Diabetic Rats via the Nitric Oxide Pathway"}]}, "item_type_id": "9", "owner": "1", "path": ["1196"], "permalink_uri": "https://doi.org/10.18999/nagjms.72.1-2.35", "pubdate": {"attribute_name": "公開日", "attribute_value": "2010-03-11"}, "publish_date": "2010-03-11", "publish_status": "0", "recid": "11045", "relation": {}, "relation_version_is_last": true, "title": ["Goshajinkigan (Chinese Herbal Medicine Niu-Che-Sen-Qi-Wan) Improves Insulin Resistance in Diabetic Rats via the Nitric Oxide Pathway"], "weko_shared_id": null}