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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 72(1-2)

Omental Flap Closure of Refractory Wounds: Rat Model

https://doi.org/10.18999/nagjms.72.1-2.91
https://doi.org/10.18999/nagjms.72.1-2.91
7a5d6bf0-72f3-4551-846a-8f9ebbfa289e
名前 / ファイル ライセンス アクション
p091-100_Hishida.pdf p091-100_Hishida.pdf (2.1 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2010-03-11
タイトル
タイトル Omental Flap Closure of Refractory Wounds: Rat Model
著者 Hishida, Masashi

× Hishida, Masashi

WEKO 33513

Hishida, Masashi

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Toriyama, Kazuhiro

× Toriyama, Kazuhiro

WEKO 33514

Toriyama, Kazuhiro

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Yamashita, Yoriko

× Yamashita, Yoriko

WEKO 33515

Yamashita, Yoriko

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Akatsuka, Shinya

× Akatsuka, Shinya

WEKO 33516

Akatsuka, Shinya

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Hayakawa, Akemi

× Hayakawa, Akemi

WEKO 33517

Hayakawa, Akemi

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Torii, Shuhei

× Torii, Shuhei

WEKO 33518

Torii, Shuhei

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Kamei, Yuzuru

× Kamei, Yuzuru

WEKO 33519

Kamei, Yuzuru

Search repository
キーワード
主題Scheme Other
主題 Adhesion
キーワード
主題Scheme Other
主題 Gastric wall defect
キーワード
主題Scheme Other
主題 Granulation
キーワード
主題Scheme Other
主題 Inflammation
キーワード
主題Scheme Other
主題 Omental flap
抄録
内容記述 Omental flaps, with their associated rich and pliable vascular arcades, are frequently used in clinical practice for the reconstruction of complex and irregular defects. There is little experimental evidence, however, to prove that omental flaps can be a useful tool for the defects. Using a gastric-wall defect model, we performed histological and immunocytochemical examinations. We created an omental flap lining a 2.0-mm defect perforating the center of the anterior wall of a rat stomach. We examined the
tissue response during gastric wall regeneration by H&E and Masson trichrome stains. We also performed immunocytochemical studies for the detection of proliferating cell nuclear antigen (PCNA), factor VIIIrelated antigen, fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF). One day after the operation, the omental flap was found to firmly adhere to the gastric serosa surrounding the
defect. An extensive inflammatory response occurred from Day 1 to 3 with dilated vessels in the omentum. From Days 3 to 7, a significant number of PCNA-positive cells, FGF-2-positive cells and VEGF-positive cells were observed at the edge of the mucosa and within the granulation tissue. On Day 4, in place of extensive inflammation, an exuberant granulation tissue response was observed from the omentum. The
defect had been covered by stratified villi by Day 7. This study demonstrated that an omental flap came to rapidly adhere to the defect serving as a source of extensive inflammation and granulation for the rich and pliable vascular arcades.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.72.1-2.91
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 72, 号 1-2, p. 91-99, 発行日 2010-02
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/12913
識別子タイプ HDL
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