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  1. H180 生物機能開発利用研究センター
  2. H180b 紀要
  3. The fish biology journal Medaka
  4. 6

Body color mutants and a transposable element affecting the tyrosinase gene of the medaka fish, Oryzias latipes

https://doi.org/10.18999/fisbjm.6.7
https://doi.org/10.18999/fisbjm.6.7
8c312d5f-f58e-462f-bf4d-d02fdb3eb957
名前 / ファイル ライセンス アクション
KJ00005673862.pdf KJ00005673862.pdf (713.1 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2010-06-17
タイトル
タイトル Body color mutants and a transposable element affecting the tyrosinase gene of the medaka fish, Oryzias latipes
言語 en
著者 Koga, Akihiko

× Koga, Akihiko

WEKO 37792

en Koga, Akihiko

Search repository
Inagaki, Hidehito

× Inagaki, Hidehito

WEKO 37793

en Inagaki, Hidehito

Search repository
Bessho, Yoshitaka

× Bessho, Yoshitaka

WEKO 37794

en Bessho, Yoshitaka

Search repository
Hori, Hirosi

× Hori, Hirosi

WEKO 37795

en Hori, Hirosi

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 Laboratory of Freshwater Fish Stocks Bioscience Center Nagoya University
権利
言語 ja
権利情報 本文データは学協会の許諾に基づきCiNiiから複製したものである
抄録
内容記述 In the medaka fish Oryzias latipes, many mutants for body colors have been isolated. Among them, albinos (i-locus alleles) are typical color mutants having amelanotic skin and red-colored eyes with no tyrosinase activity. To cast light on the molecular basis of the albino mechanism, we have cloned cDNAs for tyrosinase, a key enzyme in melanin biosynthesis, from the wild-type fish, and performed Southern blot analysis on genomic DNA from an i mutant fish with the cDNA probe. The results demonstrated a 1.9-kb insertion fragment in exon 1 of the tyrosinase gene. The fragment, designated To1, (i) carries terminal inverted repeats containing sequences quite similar to those of the Tc1 transposable element, (ii) is flanked by duplicated segments of their host chromosomes, and (iii) is present in approximately 80 copies in the genome, showing specific features of the Tc1-like transposable element. It is clear that insertion of To1 into the tyrosinase gene causes the albino body color in the i mutant. As a contrast to albino-i alleles, there is a colorless melanophore mutant b, having normally pigmented black eyes but orange-colored skin with amelanotic melanophores, thus showing the presence of a tissue-specific mechanism of melanin formation. Using the cDNA probe, Northern blot analysis on poly(A)^+RNAs from various tissues was carried out. In the wild-type, the tyrosinase mRNA was expressed in eyes and skin but not in liver, corresponding to tissue-specific melanin formation. In the b mutant, contrary to expectation, the mRNA was detected not only in eyes but also in amelanotic skin. Therefore, pigmentation of skin controlled by b is not directly related to expression of the tyrosinase gene.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Laboratory of Freshwater Fish Stocks Bioscience Center Nagoya University
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/fisbjm.6.7
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://ci.nii.ac.jp/naid/110007349010/
書誌情報 en : The Fish Biology Journal Medaka

巻 6, p. 7-15, 発行日 1994
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/13788
識別子タイプ HDL
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