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  1. B300 農学部/生命農学研究科
  2. B300a 雑誌掲載論文
  3. 学術雑誌

Secretion of three enzymes for fatty acid synthesis into mouse milk in association with fat globules, and rapid decrease of the secreted enzymes by treatment with rapamycin

http://hdl.handle.net/2237/14502
http://hdl.handle.net/2237/14502
06abf431-ecd6-4279-b54b-e7eb50b7c850
名前 / ファイル ライセンス アクション
NADANO.pdf NADANO.pdf (374.0 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2011-03-08
タイトル
タイトル Secretion of three enzymes for fatty acid synthesis into mouse milk in association with fat globules, and rapid decrease of the secreted enzymes by treatment with rapamycin
言語 en
著者 Moriya, Hitomi

× Moriya, Hitomi

WEKO 39689

en Moriya, Hitomi

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Uchida, Kana

× Uchida, Kana

WEKO 39690

en Uchida, Kana

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Okajima, Tetsuya

× Okajima, Tetsuya

WEKO 39691

en Okajima, Tetsuya

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Matsuda, Tsukasa

× Matsuda, Tsukasa

WEKO 39692

en Matsuda, Tsukasa

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Nadano, Daita

× Nadano, Daita

WEKO 39693

en Nadano, Daita

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 © 2011 Elsevier Inc.
権利
言語 en
権利情報 “NOTICE:this is the author’s version of a work that was accepted for publication in Archives of Biochemistry and Biophysics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published inArchives of Biochemistry and Biophysics. v.508, n.1, 2011, p.87-92, DOI:10.1016/j.abb.2011.01.015“
抄録
内容記述タイプ Abstract
内容記述 The mammary epithelium produces numerous lipid droplets during lactation and secretes them in plasma membrane-enclosed vesicles known as milk fat globules. The biogenesis of such fat globules is considered to provide a model for clarifying the mechanisms of lipogenesis in mammals. In the present study, we identified acetyl coenzyme A carboxylase, ATP citrate lyase, and fatty acid synthase in mouse milk. Fractionation of milk showed that these three enzymes were located predominantly in milk fat globules. The three enzymes were resistant to trypsin digestion without Triton X-100, indicating that they were not located on the outer surface of the globules and thus associated with the precursors of the globules before secretion. When a low dose of rapamycin, an inhibitor of the mammalian target of rapamycin (mTOR), was injected into lactating mice, the levels of the three enzymes in milk were decreased within 3 h after injection. Since the protein levels of the three enzymes in tissues were not obviously altered by this short-term treatment, known transcriptional control by mTOR signaling was unlikely to account for this decrease in their levels in milk. Our findings suggest a new, putatively mTOR-dependent localization of the three enzymes for de novo lipogenesis.
言語 en
出版者
出版者 ELSEVIER
言語 en
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.abb.2011.01.015
ISSN
収録物識別子タイプ PISSN
収録物識別子 0003-9861
書誌情報 en : Archives of Biochemistry and Biophysics

巻 508, 号 1, p. 87-92, 発行日 2011-04-01
著者版フラグ
値 author
URI
識別子 http://hdl.handle.net/2237/14502
識別子タイプ HDL
URI
識別子 http://dx.doi.org/10.1016/j.abb.2011.01.015
識別子タイプ DOI
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