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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 73(1-2)

Immunocytochemical Analysis for Differential Diagnosis of Thyroid Lesions Using Liquid-Based Cytology

https://doi.org/10.18999/nagjms.73.1-2.15
05e60e22-e630-4bad-b166-63cc08f134aa
名前 / ファイル ライセンス アクション
v73n12p15_24.pdf v73n12p15_24.pdf (382.6 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2011-06-01
タイトル
タイトル Immunocytochemical Analysis for Differential Diagnosis of Thyroid Lesions Using Liquid-Based Cytology
著者 HASHIMOTO, KATSUNORI

× HASHIMOTO, KATSUNORI

WEKO 40900

HASHIMOTO, KATSUNORI

Search repository
MORIMOTO, AYUMI

× MORIMOTO, AYUMI

WEKO 40901

MORIMOTO, AYUMI

Search repository
KATO, MAKOTO

× KATO, MAKOTO

WEKO 40902

KATO, MAKOTO

Search repository
TOMINAGA, YOSHIHIRO

× TOMINAGA, YOSHIHIRO

WEKO 40903

TOMINAGA, YOSHIHIRO

Search repository
MAEDA, NAGAKO

× MAEDA, NAGAKO

WEKO 40904

MAEDA, NAGAKO

Search repository
TSUZUKI, TOYONORI

× TSUZUKI, TOYONORI

WEKO 40905

TSUZUKI, TOYONORI

Search repository
YOKOI, TOYOHARU

× YOKOI, TOYOHARU

WEKO 40906

YOKOI, TOYOHARU

Search repository
NAGASAKA, TETSURO

× NAGASAKA, TETSURO

WEKO 40907

NAGASAKA, TETSURO

Search repository
キーワード
主題Scheme Other
主題 Liquid-based cytology
キーワード
主題Scheme Other
主題 Diagnostic cytology
キーワード
主題Scheme Other
主題 Thyroid
キーワード
主題Scheme Other
主題 Immunocytochemistry
抄録
内容記述 Recently, liquid-based cytology (LBC) has been widely applied to various samples in diagnostic cytology and its usefulness has been reported. In this study, we investigated thyroid cytology that applied LBC and immunocytochemistry to achieve more objective diagnosis and greater diagnostic accuracy. This study included 125 cases (57 papillary carcinomas (PCs), 22 follicular tumors, 43 adenomatous goiters and 3 with Basedow’s disease). After preparing the LBC slide, immunocytochemical staining was performed on each slide with six antibodies (HBME-1, cytokeratin 19 (CK19), high molecular weight cytokeratin (34βE12), galectin-3, CD15 and CA 19-9). All antibodies presented immunopositivity frequently in PCs, but only a few or some of them were positive in other cases. These antibodies were considered positive markers for PCs, and the most reliable marker was 34βE12; its sensitivity, specificity and diagnostic accuracy were 82.5%, 100% and 92.0%, respectively. Relations of immunocytochemical profiles against these markers were assessed using panel 34βE12, GAL-3 and CK19. More than or equal to two of these markers showed co-positive in 53 of 57 PCs, and negative for all markers was observed in only one case. In the other (non PC) cases, the former was 0 of 58 and the latter was 40 cases. In this panel, the sensitivity, specificity and diagnostic accuracy were 93.0%, 100% and 96.8%, respectively. All of these values were higher than or equal to single values of 34βE12. We concluded that the panel in this study is useful for more objective and accurate diagnosis of thyroid cytology.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.73.1-2.15
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 73, 号 1-2, p. 15-24, 発行日 2011-02
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7312/7312.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/14911
識別子タイプ HDL
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