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Immunocytochemical Analysis for Differential Diagnosis of Thyroid Lesions Using Liquid-Based Cytology
https://doi.org/10.18999/nagjms.73.1-2.15
https://doi.org/10.18999/nagjms.73.1-2.1505e60e22-e630-4bad-b166-63cc08f134aa
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
v73n12p15_24.pdf (382.6 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-06-01 | |||||
| タイトル | ||||||
| タイトル | Immunocytochemical Analysis for Differential Diagnosis of Thyroid Lesions Using Liquid-Based Cytology | |||||
| 言語 | en | |||||
| 著者 |
HASHIMOTO, KATSUNORI
× HASHIMOTO, KATSUNORI× MORIMOTO, AYUMI× KATO, MAKOTO× TOMINAGA, YOSHIHIRO× MAEDA, NAGAKO× TSUZUKI, TOYONORI× YOKOI, TOYOHARU× NAGASAKA, TETSURO |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Liquid-based cytology | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Diagnostic cytology | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Thyroid | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Immunocytochemistry | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Recently, liquid-based cytology (LBC) has been widely applied to various samples in diagnostic cytology and its usefulness has been reported. In this study, we investigated thyroid cytology that applied LBC and immunocytochemistry to achieve more objective diagnosis and greater diagnostic accuracy. This study included 125 cases (57 papillary carcinomas (PCs), 22 follicular tumors, 43 adenomatous goiters and 3 with Basedow’s disease). After preparing the LBC slide, immunocytochemical staining was performed on each slide with six antibodies (HBME-1, cytokeratin 19 (CK19), high molecular weight cytokeratin (34βE12), galectin-3, CD15 and CA 19-9). All antibodies presented immunopositivity frequently in PCs, but only a few or some of them were positive in other cases. These antibodies were considered positive markers for PCs, and the most reliable marker was 34βE12; its sensitivity, specificity and diagnostic accuracy were 82.5%, 100% and 92.0%, respectively. Relations of immunocytochemical profiles against these markers were assessed using panel 34βE12, GAL-3 and CK19. More than or equal to two of these markers showed co-positive in 53 of 57 PCs, and negative for all markers was observed in only one case. In the other (non PC) cases, the former was 0 of 58 and the latter was 40 cases. In this panel, the sensitivity, specificity and diagnostic accuracy were 93.0%, 100% and 96.8%, respectively. All of these values were higher than or equal to single values of 34βE12. We concluded that the panel in this study is useful for more objective and accurate diagnosis of thyroid cytology. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.73.1-2.15 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7312/7312.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 73, 号 1-2, p. 15-24, 発行日 2011-02 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/14911 | |||||
| 識別子タイプ | HDL | |||||
