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ASSOCIATION OF UGT1A1 GLY71ARG WITH URINE UROBILINOGEN
https://doi.org/10.18999/nagjms.73.1-2.33
https://doi.org/10.18999/nagjms.73.1-2.335c1966ab-14b1-4d40-bb62-74a8a574717f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
v73n12p33_40.pdf (911.6 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-06-01 | |||||
| タイトル | ||||||
| タイトル | ASSOCIATION OF UGT1A1 GLY71ARG WITH URINE UROBILINOGEN | |||||
| 言語 | en | |||||
| 著者 |
KATAOKA, RYUJI
× KATAOKA, RYUJI× KIMATA, AKIKO× YAMAMOTO, KANAMI× HIROSAWA, NAOKO× UEYAMA, JUN× KONDO, TAKAAKI× OKADA, RIEKO× KAWAI, SAYO× HISHIDA, ASAHI× NAITO, MARIKO× MORITA, EMI× WAKAI, KENJI× HAMAJIMA, NOBUYUKI |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Bilirubin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Urobilinogen | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | UGT1A | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Bilirubin is glucoronized by uridine diphosphate-glucuronosyl transferase 1A1 (UGT1A1) mainly in the liver, and excreted into bile. The conjugated form is metabolized into the unconjugated form, and then into urobilinogen by bacteria in the intestine. Unconjugated bilirubin and urobilinogen are absorbed into the blood stream. The kidney filtrates conjugated bilurubin and urobilinogen into urine. Accordingly, the reduced enzyme activity of UGT1A1 may decrease serum conjugated bilirubin levels, resulting in a lower frequency of positive results of urine bilirubin and urobilinogen. This study examined the associations of UGT1A1 Gly71Arg (UGT1A1*6) with urine bilirubin and urobilinogen, as well as serum AST, ALT and GGT. Subjects were 5,172 inhabitants 35 to 69 years old who participated in a cohort study in Nagoya from June 2008 to May 2010. Among them, data from 5,151 participants (1,465 males and 3,686 females) were available for analysis. The age-sex-adjusted odds ratio (OR) of ArgArg relative to GlyGly was 1.37 (95% confidence interval (95% CI), 0.55–1.23) for bilirubin, and 1.67 (95% CI, 0.86–3.26) for urobilinogen. Those of ArgArg+ArgGly were 0.87 (95% CI, 0.59–1.27) and 1.50 (95% CI, 1.17–1.94), respectively. AST, ALT and GGT levels had no associations with the genotype. Although the significant association for urobilinogen was contrary to the biological expectation, this study indicated that UGT1A1 Gly71Arg may be a genetic factor of urine urobilinogen. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.73.1-2.33 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7312/7312.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 73, 号 1-2, p. 33-40, 発行日 2011-02 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/14913 | |||||
| 識別子タイプ | HDL | |||||
