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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 73(1-2)

ASSOCIATION OF UGT1A1 GLY71ARG WITH URINE UROBILINOGEN

https://doi.org/10.18999/nagjms.73.1-2.33
https://doi.org/10.18999/nagjms.73.1-2.33
5c1966ab-14b1-4d40-bb62-74a8a574717f
名前 / ファイル ライセンス アクション
v73n12p33_40.pdf v73n12p33_40.pdf (911.6 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2011-06-01
タイトル
タイトル ASSOCIATION OF UGT1A1 GLY71ARG WITH URINE UROBILINOGEN
言語 en
著者 KATAOKA, RYUJI

× KATAOKA, RYUJI

WEKO 40916

en KATAOKA, RYUJI

Search repository
KIMATA, AKIKO

× KIMATA, AKIKO

WEKO 40917

en KIMATA, AKIKO

Search repository
YAMAMOTO, KANAMI

× YAMAMOTO, KANAMI

WEKO 40918

en YAMAMOTO, KANAMI

Search repository
HIROSAWA, NAOKO

× HIROSAWA, NAOKO

WEKO 40919

en HIROSAWA, NAOKO

Search repository
UEYAMA, JUN

× UEYAMA, JUN

WEKO 40920

en UEYAMA, JUN

Search repository
KONDO, TAKAAKI

× KONDO, TAKAAKI

WEKO 40921

en KONDO, TAKAAKI

Search repository
OKADA, RIEKO

× OKADA, RIEKO

WEKO 40922

en OKADA, RIEKO

Search repository
KAWAI, SAYO

× KAWAI, SAYO

WEKO 40923

en KAWAI, SAYO

Search repository
HISHIDA, ASAHI

× HISHIDA, ASAHI

WEKO 40924

en HISHIDA, ASAHI

Search repository
NAITO, MARIKO

× NAITO, MARIKO

WEKO 40925

en NAITO, MARIKO

Search repository
MORITA, EMI

× MORITA, EMI

WEKO 40926

en MORITA, EMI

Search repository
WAKAI, KENJI

× WAKAI, KENJI

WEKO 40927

en WAKAI, KENJI

Search repository
HAMAJIMA, NOBUYUKI

× HAMAJIMA, NOBUYUKI

WEKO 40928

en HAMAJIMA, NOBUYUKI

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 Bilirubin
キーワード
主題Scheme Other
主題 Urobilinogen
キーワード
主題Scheme Other
主題 UGT1A
抄録
内容記述 Bilirubin is glucoronized by uridine diphosphate-glucuronosyl transferase 1A1 (UGT1A1) mainly in the liver, and excreted into bile. The conjugated form is metabolized into the unconjugated form, and then into urobilinogen by bacteria in the intestine. Unconjugated bilirubin and urobilinogen are absorbed into the blood stream. The kidney filtrates conjugated bilurubin and urobilinogen into urine. Accordingly, the reduced enzyme activity of UGT1A1 may decrease serum conjugated bilirubin levels, resulting in a lower frequency of positive results of urine bilirubin and urobilinogen. This study examined the associations of UGT1A1 Gly71Arg (UGT1A1*6) with urine bilirubin and urobilinogen, as well as serum AST, ALT and GGT. Subjects were 5,172 inhabitants 35 to 69 years old who participated in a cohort study in Nagoya from June 2008 to May 2010. Among them, data from 5,151 participants (1,465 males and 3,686 females) were available for analysis. The age-sex-adjusted odds ratio (OR) of ArgArg relative to GlyGly was 1.37 (95% confidence interval (95% CI), 0.55–1.23) for bilirubin, and 1.67 (95% CI, 0.86–3.26) for urobilinogen. Those of ArgArg+ArgGly were 0.87 (95% CI, 0.59–1.27) and 1.50 (95% CI, 1.17–1.94), respectively. AST, ALT and GGT levels had no associations with the genotype. Although the significant association for urobilinogen was contrary to the biological expectation, this study indicated that UGT1A1 Gly71Arg may be a genetic factor of urine urobilinogen.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/nagjms.73.1-2.33
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7312/7312.html
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0027-7622
書誌情報 en : Nagoya Journal of Medical Science

巻 73, 号 1-2, p. 33-40, 発行日 2011-02
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7312/7312.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/14913
識別子タイプ HDL
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