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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 73(1-2)

SLC22A12 W258X FREQUENCY ACCORDING TO SERUM URIC ACID LEVEL AMONG JAPANESE HEALTH CHECKUP EXAMINEES

https://doi.org/10.18999/nagjms.73.1-2.41
https://doi.org/10.18999/nagjms.73.1-2.41
72a59858-3e89-4bde-b859-28629f35412d
名前 / ファイル ライセンス アクション
v73n12p41_48.pdf v73n12p41_48.pdf (293.2 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2011-06-01
タイトル
タイトル SLC22A12 W258X FREQUENCY ACCORDING TO SERUM URIC ACID LEVEL AMONG JAPANESE HEALTH CHECKUP EXAMINEES
言語 en
著者 KURIKI, SAYAKA

× KURIKI, SAYAKA

WEKO 40929

en KURIKI, SAYAKA

Search repository
OKADA, RIEKO

× OKADA, RIEKO

WEKO 40930

en OKADA, RIEKO

Search repository
SUZUKI, KOJI

× SUZUKI, KOJI

WEKO 40931

en SUZUKI, KOJI

Search repository
ITO, YOSHINORI

× ITO, YOSHINORI

WEKO 40932

en ITO, YOSHINORI

Search repository
MORITA, EMI

× MORITA, EMI

WEKO 40933

en MORITA, EMI

Search repository
NAITO, MARIKO

× NAITO, MARIKO

WEKO 40934

en NAITO, MARIKO

Search repository
HAMAJIMA, NOBUYUKI

× HAMAJIMA, NOBUYUKI

WEKO 40935

en HAMAJIMA, NOBUYUKI

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 Hypouricemia
キーワード
主題Scheme Other
主題 Urate transporter
キーワード
主題Scheme Other
主題 SLC22A12 W258X
キーワード
主題Scheme Other
主題 Polymerase chain reaction with confronting two-pair primers
抄録
内容記述 Although the SLC22A12 (uric acid transporter 1) 258X allele is known to cause hypouricemia, the genotype frequency according to the serum uric acid (SUA) level has not been reported. This study investigated the SLC22A12 258WX frequency according to SUA levels among Japanese health-checkup examinees. In addition, the changes were reported in SUA levels during five years for individuals with 258WX. Subjects were 746 Japanese aged 39–86 years in 2003. Their SUA records were linked during the five years from 2003 to 2007. SLC22A12 W258X was genotyped using a polymerase chain reaction with confronting two-pair primers. The 258X allele comprised 1.9% (95% CI, 1.3–2.8%) of all the subjects. Among those with SUA <3.0 mg/dL, 258WX was more common in males (66.7%, 95% CI, 22.2–95.7%) than in females (39.3%, 95% CI, 21.5–59.4%). Among subjects with a SUA of 3.0–4.9 mg/dL, those with 258WX totaled 10.7% (95% CI, 4.0–21.9%) and 2.6% (95% CI, 1.1–5.0%), respectively. There were no subjects with 258WX among those with a SUA of 5.0 mg/dL or more. During the five years from 2003 to 2007, the changes in SUA among 23 individuals with 258WX were found to be similar to those among 258WW subjects (n=536). This study indicated that SLC22A12 258WX was more common among those with a lower serum uric acid concentration. The observed SUA level changes in individuals with 258WX suggested that lifestyle factors could influence the levels of those with 258WX.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/nagjms.73.1-2.41
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7312/7312.html
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0027-7622
書誌情報 en : Nagoya Journal of Medical Science

巻 73, 号 1-2, p. 41-48, 発行日 2011-02
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/14914
識別子タイプ HDL
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