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However, the determinants of baseline peritoneal solute transport rate remain uncertain. The aim of this study was to investigate the relationship between peritoneal local inflammation, angiogenesis and systemic inflammation and baseline peritoneal permeability. Methods: Peritoneal biopsy specimens from 42 pre-dialysis uraemic patients and 11 control individuals were investigated. Immunohistochemistry for CD68-positive macrophages, chymase- and tryptase-positive mast cells, interleukin-6 (IL-6)-positive cells, CD3-positive T cells, CD20-positive B cells, neutrophils and CD31- and pathologische anatomie Leiden-endothelium (PAL-E)- positive blood vessels in the peritoneum was performed. Baseline dialysate-to-plasma ratio for creatinine (D/P Cr) was determined within 6 months of PD induction. Clinical and laboratory parameters were measured at the time of peritoneal biopsy. Factors associated with peritoneal permeability were assessed by multiple linear regression analysis. 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  1. C100 医学部/医学系研究科
  2. C100d 学位論文
  3. 博士論文(医博・論医博)

Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients

http://hdl.handle.net/2237/14924
http://hdl.handle.net/2237/14924
6d2091ac-fa68-4a71-b9c2-31ca78b057ed
名前 / ファイル ライセンス アクション
k9095.pdf k9095.pdf (581.7 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2011-06-07
タイトル
タイトル Peritoneal macrophage infiltration is correlated with baseline peritoneal solute transport rate in peritoneal dialysis patients
言語 en
著者 Sawai, Akiho

× Sawai, Akiho

WEKO 40980

en Sawai, Akiho

Search repository
Ito, Yasuhiko

× Ito, Yasuhiko

WEKO 40981

en Ito, Yasuhiko

Search repository
Mizuno, Masashi

× Mizuno, Masashi

WEKO 40982

en Mizuno, Masashi

Search repository
Suzuki, Yasuhiro

× Suzuki, Yasuhiro

WEKO 40983

en Suzuki, Yasuhiro

Search repository
Toda, Susumu

× Toda, Susumu

WEKO 40984

en Toda, Susumu

Search repository
Ito, Isao

× Ito, Isao

WEKO 40985

en Ito, Isao

Search repository
Hattori, Ryohei

× Hattori, Ryohei

WEKO 40986

en Hattori, Ryohei

Search repository
Matsukawa, Yoshihisa

× Matsukawa, Yoshihisa

WEKO 40987

en Matsukawa, Yoshihisa

Search repository
Gotoh, Momokazu

× Gotoh, Momokazu

WEKO 40988

en Gotoh, Momokazu

Search repository
Takei, Yoshifumi

× Takei, Yoshifumi

WEKO 40989

en Takei, Yoshifumi

Search repository
Yuzawa, Yukio

× Yuzawa, Yukio

WEKO 40990

en Yuzawa, Yukio

Search repository
Matsuo, Seiichi

× Matsuo, Seiichi

WEKO 40991

en Matsuo, Seiichi

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 © The Author 2010. Published by Oxford University Press on behalf of ERA-EDTA.
キーワード
主題Scheme Other
主題 blood vessel
キーワード
主題Scheme Other
主題 D/P Cr
キーワード
主題Scheme Other
主題 inflammation
キーワード
主題Scheme Other
主題 macrophage
キーワード
主題Scheme Other
主題 mast cell
抄録
内容記述 Background: High baseline peritoneal solute transport rate is reportedly associated with reduced patient and technique survival in continuous peritoneal dialysis (PD) patients. However, the determinants of baseline peritoneal solute transport rate remain uncertain. The aim of this study was to investigate the relationship between peritoneal local inflammation, angiogenesis and systemic inflammation and baseline peritoneal permeability. Methods: Peritoneal biopsy specimens from 42 pre-dialysis uraemic patients and 11 control individuals were investigated. Immunohistochemistry for CD68-positive macrophages, chymase- and tryptase-positive mast cells, interleukin-6 (IL-6)-positive cells, CD3-positive T cells, CD20-positive B cells, neutrophils and CD31- and pathologische anatomie Leiden-endothelium (PAL-E)- positive blood vessels in the peritoneum was performed. Baseline dialysate-to-plasma ratio for creatinine (D/P Cr) was determined within 6 months of PD induction. Clinical and laboratory parameters were measured at the time of peritoneal biopsy. Factors associated with peritoneal permeability were assessed by multiple linear regression analysis. Results: Pre-dialysis uraemic peritoneum showed infiltration by CD68-positive macrophages, and mast cells, as compared with controls. Baseline D/P Cr was correlated with density of CD68-positive macrophages (P < 0.001), IL-6-positive cells (P < 0.001), CD31-positive (P < 0.05) and PAL-E-positive blood vessels (P < 0.05) and serum albumin (P < 0.05). However, baseline peritoneal permeability was not correlated with infiltration by mast cells, B cells, T cells, neutrophils, serum C-reactive protein or other clinical factors. On multiple linear regression analysis, the number of CD68-positive macrophages in peritoneum was an independent predictor for baseline peritoneal permeability (P = 0.009). Conclusions: Peritoneal macrophage infiltration is predominant in uraemic patients and is an important factor in predicting baseline peritoneal permeability.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成23年3月25日 澤井晶穂氏の博士論文として提出された
言語 ja
内容記述タイプ Other
内容記述
内容記述 [First published online] 2010-11-22
言語 en
内容記述タイプ Other
出版者
言語 en
出版者 Oxford University Press
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1093/ndt/gfq702
ISSN
収録物識別子タイプ EISSN
収録物識別子 1460-2385
書誌情報 en : Nephrology Dialysis Transplantation

巻 26, 号 7, p. 2322-2332, 発行日 2011-07
学位名
言語 ja
学位名 博士(医学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13901
言語 ja
学位授与機関名 名古屋大学
言語 en
学位授与機関名 NAGOYA University
学位授与年度
学位授与年度 2011
学位授与年月日
学位授与年月日 2011-07-01
学位授与番号
学位授与番号 甲第9095号
著者版フラグ
値 publisher
URI
識別子 http://dx.doi.org/10.1093/ndt/gfq702
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/14924
識別子タイプ HDL
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