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We investigated the status of the cochleae in patients with vestibular schwannoma by evaluating the signal intensity of cochlear fluid on pre- and post-contrast enhanced thin section three-dimensional fluid attenuated inversion recovery (3D-FLAIR). Methods: Twenty-eight patients were retrospectively analyzed. Post-contrast images were obtained in 18 patients and 20 patients had the records of their pure-tone audiometry. Regions of interest of both cochleae (C) and of the medulla oblongata (M) were determined on 3D-FLAIR images by referring to 3D-heavily T2-weighted images on a workstation. The signal intensity ratio between C and M on the 3D-FLAIR images (CM ratio) was then evaluated. In addition, correlation between the CM ratio and the hearing level was also evaluated. Results: The CM ratio of the affected side was significantly higher than that of the unaffected side (p\u003c0.001). In the affected side, post-contrast signal elevation was observed (p\u003c0.005). 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Increased signal intensity of the cochlea on pre- and post-contrast enhanced 3D-FLAIR in patients with vestibular schwannoma
http://hdl.handle.net/2237/15101
http://hdl.handle.net/2237/151013138f658-bce7-44a2-8d95-eaabe64a86ce
名前 / ファイル | ライセンス | アクション |
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k8943.pdf (282.6 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2011-07-21 | |||||
タイトル | ||||||
タイトル | Increased signal intensity of the cochlea on pre- and post-contrast enhanced 3D-FLAIR in patients with vestibular schwannoma | |||||
言語 | en | |||||
著者 |
Yamazaki, Masahiro
× Yamazaki, Masahiro× Naganawa, Shinji× Kawai, Hisashi× Nihashi, Takashi× Fukatsu, Hiroshi× Nakashima, Tsutomu |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | The final publication is available at www.springerlink.com | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | magnetic resonance | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | FLAIR | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | high resolution | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | vestibular schwannoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cochlea | |||||
抄録 | ||||||
内容記述 | Introduction: In the vestibular schwannoma patients, the pathophysiologic mechanism of inner ear involvement is still unclear. We investigated the status of the cochleae in patients with vestibular schwannoma by evaluating the signal intensity of cochlear fluid on pre- and post-contrast enhanced thin section three-dimensional fluid attenuated inversion recovery (3D-FLAIR). Methods: Twenty-eight patients were retrospectively analyzed. Post-contrast images were obtained in 18 patients and 20 patients had the records of their pure-tone audiometry. Regions of interest of both cochleae (C) and of the medulla oblongata (M) were determined on 3D-FLAIR images by referring to 3D-heavily T2-weighted images on a workstation. The signal intensity ratio between C and M on the 3D-FLAIR images (CM ratio) was then evaluated. In addition, correlation between the CM ratio and the hearing level was also evaluated. Results: The CM ratio of the affected side was significantly higher than that of the unaffected side (p<0.001). In the affected side, post-contrast signal elevation was observed (p<0.005). In 13 patients (26 cochleae) who underwent both gadolinium injection and the pure-tone audiometry, the postcontrast CM ratio correlated with hearing level (p<0.05). Conclusion: The results of present study suggest that alteration of cochlear fluid composition and increased permeability of the blood-labyrinthine barrier exist in the affected side in patients with vestibular schwannoma. Furthermore, although weak, positive correlation between post-contrast cochlear signal intensity on 3D-FLAIR and hearing level warrants further study to clarify the relationship between 3D-FLAIR findings and prognosis of hearing preservation surgery. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成22年9月28日 山崎雅弘氏の博士論文として提出された | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Springer | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_db06 | |||||
タイプ | doctoral thesis | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s00234-009-0588-6 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0028-3940 | |||||
書誌情報 |
en : Neuroradiology 巻 51, 号 12, p. 855-863, 発行日 2009-12 |
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学位名 | ||||||
言語 | ja | |||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 13901 | |||||
言語 | ja | |||||
学位授与機関名 | 名古屋大学 | |||||
言語 | en | |||||
学位授与機関名 | NAGOYA University | |||||
学位授与年度 | ||||||
学位授与年度 | 2009 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2009-12-01 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第8943号 | |||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://dx.doi.org/10.1007/s00234-009-0588-6 | |||||
識別子タイプ | DOI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/15101 | |||||
識別子タイプ | HDL |