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  1. C100 医学部/医学系研究科
  2. C100d 学位論文
  3. 博士論文(医博・論医博)

Increased signal intensity of the cochlea on pre- and post-contrast enhanced 3D-FLAIR in patients with vestibular schwannoma

http://hdl.handle.net/2237/15101
http://hdl.handle.net/2237/15101
3138f658-bce7-44a2-8d95-eaabe64a86ce
名前 / ファイル ライセンス アクション
k8943.pdf k8943.pdf (282.6 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2011-07-21
タイトル
タイトル Increased signal intensity of the cochlea on pre- and post-contrast enhanced 3D-FLAIR in patients with vestibular schwannoma
言語 en
著者 Yamazaki, Masahiro

× Yamazaki, Masahiro

WEKO 41721

en Yamazaki, Masahiro

Search repository
Naganawa, Shinji

× Naganawa, Shinji

WEKO 41722

en Naganawa, Shinji

Search repository
Kawai, Hisashi

× Kawai, Hisashi

WEKO 41723

en Kawai, Hisashi

Search repository
Nihashi, Takashi

× Nihashi, Takashi

WEKO 41724

en Nihashi, Takashi

Search repository
Fukatsu, Hiroshi

× Fukatsu, Hiroshi

WEKO 41725

en Fukatsu, Hiroshi

Search repository
Nakashima, Tsutomu

× Nakashima, Tsutomu

WEKO 41726

en Nakashima, Tsutomu

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 The final publication is available at www.springerlink.com
キーワード
主題Scheme Other
主題 magnetic resonance
キーワード
主題Scheme Other
主題 FLAIR
キーワード
主題Scheme Other
主題 high resolution
キーワード
主題Scheme Other
主題 vestibular schwannoma
キーワード
主題Scheme Other
主題 cochlea
抄録
内容記述 Introduction: In the vestibular schwannoma patients, the pathophysiologic mechanism of inner ear involvement is still unclear. We investigated the status of the cochleae in patients with vestibular schwannoma by evaluating the signal intensity of cochlear fluid on pre- and post-contrast enhanced thin section three-dimensional fluid attenuated inversion recovery (3D-FLAIR). Methods: Twenty-eight patients were retrospectively analyzed. Post-contrast images were obtained in 18 patients and 20 patients had the records of their pure-tone audiometry. Regions of interest of both cochleae (C) and of the medulla oblongata (M) were determined on 3D-FLAIR images by referring to 3D-heavily T2-weighted images on a workstation. The signal intensity ratio between C and M on the 3D-FLAIR images (CM ratio) was then evaluated. In addition, correlation between the CM ratio and the hearing level was also evaluated. Results: The CM ratio of the affected side was significantly higher than that of the unaffected side (p<0.001). In the affected side, post-contrast signal elevation was observed (p<0.005). In 13 patients (26 cochleae) who underwent both gadolinium injection and the pure-tone audiometry, the postcontrast CM ratio correlated with hearing level (p<0.05). Conclusion: The results of present study suggest that alteration of cochlear fluid composition and increased permeability of the blood-labyrinthine barrier exist in the affected side in patients with vestibular schwannoma. Furthermore, although weak, positive correlation between post-contrast cochlear signal intensity on 3D-FLAIR and hearing level warrants further study to clarify the relationship between 3D-FLAIR findings and prognosis of hearing preservation surgery.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成22年9月28日 山崎雅弘氏の博士論文として提出された
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Springer
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s00234-009-0588-6
ISSN
収録物識別子タイプ PISSN
収録物識別子 0028-3940
書誌情報 en : Neuroradiology

巻 51, 号 12, p. 855-863, 発行日 2009-12
学位名
言語 ja
学位名 博士(医学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13901
言語 ja
学位授与機関名 名古屋大学
言語 en
学位授与機関名 NAGOYA University
学位授与年度
学位授与年度 2009
学位授与年月日
学位授与年月日 2009-12-01
学位授与番号
学位授与番号 甲第8943号
著者版フラグ
値 publisher
URI
識別子 http://dx.doi.org/10.1007/s00234-009-0588-6
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/15101
識別子タイプ HDL
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