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EARLY PREDICTION OF RESPONSE TO NEOADJUVANT CHEMOTHERAPY FOR LOCALLY ADVANCED BREAST CANCER USING MRI
https://doi.org/10.18999/nagjms.73.3-4.147
https://doi.org/10.18999/nagjms.73.3-4.1472a5afcf8-d3a8-49b2-a078-97982f83be82
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
v73n34p147_156.pdf (322.0 kB)
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| アイテムタイプ | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2011-08-24 | |||||
| タイトル | ||||||
| タイトル | EARLY PREDICTION OF RESPONSE TO NEOADJUVANT CHEMOTHERAPY FOR LOCALLY ADVANCED BREAST CANCER USING MRI | |||||
| 言語 | en | |||||
| 著者 |
KAWAMURA, MARIKO
× KAWAMURA, MARIKO× SATAKE, HIROKO× ISHIGAKI, SATOKO× NISHIO, AKIKO× SAWAKI, MASATAKA× NAGANAWA, SHINJI |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Breast cancer | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Neoadjuvant chemotherapy | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | MRI | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Response prediction | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Neoadjuvant chemotherapy (NAC) is the favored treatment of choice among locally advanced breast cancer patients because it significantly increases the possibility of breast-conserving surgery. However, for non-responders, an early prediction of response to NAC is essential. The purpose of this study was to determine whether an early prediction of response to NAC is possible using MRI. Eleven breast cancer patients (12 lesions) scheduled to receive NAC were recruited for this study. The patients were examined by MRI prior to and after the first and fourth courses of anthracycline-containing chemotherapy and after subsequent taxane-containing chemotherapy. Lesions were divided into 2 types (mass type and non-mass type) based on contrast MRI prior to chemotherapy. Among 8 mass types, 6 were responders (R) and 2 were non-responders (NR). R cases showed either an increased apparent diffusion coefficient (ADC) or volume reduction after the first course of NAC, whereas NR cases showed neither (p<0.005). Of the 4 non-mass types, 2 were R and 2 were NR. Changes in ADC or volume after the first course of NAC may indicate chemo-sensitivity for mass-type breast cancer. However, the same method cannot be used to predict the response to NAC for non-mass types. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.73.3-4.147 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7334/7334.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 73, 号 3-4, p. 147-156, 発行日 2011-08 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/15357 | |||||
| 識別子タイプ | HDL | |||||
