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  1. F100 環境医学研究所
  2. F100b 紀要
  3. Environmental medicine : annual report of the Research Institute of Environmental Medicine
  4. 46(1-2)

Search for Complex Disease Genes: Achievements and Failures

https://doi.org/10.18999/envm.46.1
https://doi.org/10.18999/envm.46.1
686953ad-dd01-477a-a507-1d6abf2c138c
名前 / ファイル ライセンス アクション
KJ00000034852.pdf KJ00000034852.pdf (900.7 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2006-01-05
タイトル
タイトル Search for Complex Disease Genes: Achievements and Failures
言語 en
著者 AXENOVICH, Tatiana I.

× AXENOVICH, Tatiana I.

WEKO 3073

en AXENOVICH, Tatiana I.

Search repository
BORODIN, Pavel M.

× BORODIN, Pavel M.

WEKO 3074

en BORODIN, Pavel M.

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 complex diseases
キーワード
主題Scheme Other
主題 linkage analysis
キーワード
主題Scheme Other
主題 QTL mapping
キーワード
主題Scheme Other
主題 allelic association
キーワード
主題Scheme Other
主題 statistical genetics
抄録
内容記述 In this paper we review current methods of mapping complex disease genes. We outline the rationale of these methods, fields of their application, their strong and weak points. The progress in genetic mapping of human diseases has been mainly concerned with the Mendelian diseases. Achievements in identification and mapping of complex disease genes have been less impressive. A substantial progress has been reached in development of statistical methods of complex disease mapping. However, most of them are still based on the implicit assumption that there is a gene with a significant effect. They are effective in cases when a disease is due to mutations in structural genes or in their genetic neighborhood. Statistical methods are capable of isolating the effect of the major gene from the effects of genetic background and environmental noise, and localizing it. However, these methods fail when several genes of equal effect are involved. What hinders the progress in mapping of complex disease gene is not the drawbacks of the methods themselves, but underdevelopment of the general concept of genetic anatomy of complex traits.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 国立情報学研究所で電子化したコンテンツを使用している。
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Research Institute of Environmental Medicine, Nagoya University
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/envm.46.1
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 02870517
書誌情報 en : Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University

巻 46, 号 1/2, p. 1-6, 発行日 2002-12
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/2772
識別子タイプ HDL
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