WEKO3
アイテム
Search for Complex Disease Genes: Achievements and Failures
https://doi.org/10.18999/envm.46.1
https://doi.org/10.18999/envm.46.1686953ad-dd01-477a-a507-1d6abf2c138c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00000034852.pdf (900.7 kB)
|
|
| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-01-05 | |||||
| タイトル | ||||||
| タイトル | Search for Complex Disease Genes: Achievements and Failures | |||||
| 言語 | en | |||||
| 著者 |
AXENOVICH, Tatiana I.
× AXENOVICH, Tatiana I.× BORODIN, Pavel M. |
|||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | complex diseases | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | linkage analysis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | QTL mapping | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | allelic association | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | statistical genetics | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In this paper we review current methods of mapping complex disease genes. We outline the rationale of these methods, fields of their application, their strong and weak points. The progress in genetic mapping of human diseases has been mainly concerned with the Mendelian diseases. Achievements in identification and mapping of complex disease genes have been less impressive. A substantial progress has been reached in development of statistical methods of complex disease mapping. However, most of them are still based on the implicit assumption that there is a gene with a significant effect. They are effective in cases when a disease is due to mutations in structural genes or in their genetic neighborhood. Statistical methods are capable of isolating the effect of the major gene from the effects of genetic background and environmental noise, and localizing it. However, these methods fail when several genes of equal effect are involved. What hinders the progress in mapping of complex disease gene is not the drawbacks of the methods themselves, but underdevelopment of the general concept of genetic anatomy of complex traits. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 国立情報学研究所で電子化したコンテンツを使用している。 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Research Institute of Environmental Medicine, Nagoya University | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/envm.46.1 | |||||
| ID登録タイプ | JaLC | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 02870517 | |||||
| 書誌情報 |
en : Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University 巻 46, 号 1/2, p. 1-6, 発行日 2002-12 |
|||||
| フォーマット | ||||||
| 値 | application/pdf | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/2772 | |||||
| 識別子タイプ | HDL | |||||
