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Effect of PPARα Ligand on TNFα -Dependent Expression of EGF Receptor in Human Glioma Cell Line
https://doi.org/10.18999/envm.46.33
https://doi.org/10.18999/envm.46.338802f84d-13f9-4460-bfb4-ace093e5034f
名前 / ファイル | ライセンス | アクション |
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KJ00000034856.pdf (346.5 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-01-05 | |||||
タイトル | ||||||
タイトル | Effect of PPARα Ligand on TNFα -Dependent Expression of EGF Receptor in Human Glioma Cell Line | |||||
言語 | en | |||||
著者 |
WAKABAYASHI, Kenichi
× WAKABAYASHI, Kenichi× KAMBE, Fukushi× NAGAYA, Takashi× KATO, Mihoko× SAITO, Kiyoshi× YOSHIDA, Jun× SEO, Hisao |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glioma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | EGFR | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PPARα | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TNFα | |||||
抄録 | ||||||
内容記述 | In glioma cells, tumor necrosis factor alpha (TNFα) was reported to increase the number of epidermal growth factor receptor (EGFR) that mediates EGF-dependent cell proliferation. On the other hand, ligands for peroxisome proliferator-activated receptor alpha (PPARα) have been reported to inhibit proliferation of various tumor cells. In this study, we evaluated the influence of synthetic PPARα ligand, Wy 14643, on basal and TNFα-dependent expression of EGFR in U251MG cells derived from a human malignant glioma. Northern blot analysis revealed that TNFα increased EGFR mRNA levels and that this increase was markedly suppressed by Wy 14643. However, it had only marginal effect on the basal levels of EGFR mRNA. These results demonstrate that the activation of PPARα leads to the inhibition of the TNFα-dependent EGFR expression in human malignant glioma cells. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | 国立情報学研究所で電子化したコンテンツを使用している。 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Research Institute of Environmental Medicine, Nagoya University | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/envm.46.33 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 02870517 | |||||
書誌情報 |
en : Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University 巻 46, 号 1/2, p. 33-35, 発行日 2002-12 |
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フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/2776 | |||||
識別子タイプ | HDL |