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Developmental Characteristics of Mice Lacking the DNA Excision Repair Gene XPG
https://doi.org/10.18999/envm.46.66
https://doi.org/10.18999/envm.46.66437740da-1049-4f09-9bb6-6e3ee333c373
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00000034866.pdf (400.0 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-01-05 | |||||
| タイトル | ||||||
| タイトル | Developmental Characteristics of Mice Lacking the DNA Excision Repair Gene XPG | |||||
| 言語 | en | |||||
| 著者 |
SUN, Xue-Zhi
× SUN, Xue-Zhi× HARADA, Yoshi-Nobu× GUI, Chun× ZHANG, Rui× TAKAHASHI, Sentaro× Fukui, Yoshihiro× MURATA, Yoshiharu |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cerebellum | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cerebrum | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cockayne syndrome | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | xeroderma pigmentosum | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A new mutant mice that carried the nonfunctional xeroderma pigmentosum group G gene (the mouse counterpart of the human XPG gene) alleles have been generated through a gene-targeting and embryonic stem cell technology. The developmental characteristics of the -/- homozygous mice identified by PCR and Northern blotting were studied. Body size of mutants was clearly smaller than normal littermates from the age of 6 days. Such postnatal growth failure became more and more obvious with developmental proceeding. By postnatal day 23, all of the mutants died after showing great weakness and emaciation. These symptoms in the mutants were similar to the clinical phenotypes of Cockayne syndrome. Moreover, some progressive neurological signs also appeared in the homozygous mice around 2 weeks after birth. When compared development of brains at postnatal day 19, both cerebrum and cerebellum of the xpg-mutants were smaller and significant difference from the wild-types. Their weights only accounted for 79.5% and 66.9% of those in the wild-types, respectively. Such microcephaly and progressive neurological signs mimicked the clinical phenotype of the patients with XPG. We believe that the xpg null mice will be an animal model for studying mechanisms concerning the clinic symptoms and Cockayne syndrome in XPG patients. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 国立情報学研究所で電子化したコンテンツを使用している。 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Research Institute of Environmental Medicine, Nagoya University | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/envm.46.66 | |||||
| ID登録タイプ | JaLC | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 02870517 | |||||
| 書誌情報 |
en : Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University 巻 46, 号 1/2, p. 66-69, 発行日 2002-12 |
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| フォーマット | ||||||
| 値 | application/pdf | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/2786 | |||||
| 識別子タイプ | HDL | |||||
