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  1. F100 環境医学研究所
  2. F100b 紀要
  3. Environmental medicine : annual report of the Research Institute of Environmental Medicine
  4. 46(1-2)

Altered I_f Channel Gene Expression in Mouse Hearts after Myocardial Infarction

https://doi.org/10.18999/envm.46.89
https://doi.org/10.18999/envm.46.89
3e1a8a1c-6502-448a-98a5-ac291d9db7f0
名前 / ファイル ライセンス アクション
KJ00000034874.pdf KJ00000034874.pdf (252.6 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2006-01-05
タイトル
タイトル Altered I_f Channel Gene Expression in Mouse Hearts after Myocardial Infarction
言語 en
著者 TAKEMURA, Haruki

× TAKEMURA, Haruki

WEKO 3178

en TAKEMURA, Haruki

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NIWA, Noriko

× NIWA, Noriko

WEKO 3179

en NIWA, Noriko

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HOJO, Mayumi

× HOJO, Mayumi

WEKO 3180

en HOJO, Mayumi

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LEE, Jong-Kook

× LEE, Jong-Kook

WEKO 3181

en LEE, Jong-Kook

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YASUI, Kenji

× YASUI, Kenji

WEKO 3182

en YASUI, Kenji

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UEDA, Yuichi

× UEDA, Yuichi

WEKO 3183

en UEDA, Yuichi

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KODAMA, Itsuo

× KODAMA, Itsuo

WEKO 3184

en KODAMA, Itsuo

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 I_f
キーワード
主題Scheme Other
主題 HCN gene
キーワード
主題Scheme Other
主題 mouse
キーワード
主題Scheme Other
主題 myocardial infarction
キーワード
主題Scheme Other
主題 hypertrophy
抄録
内容記述 I_f channels play a key role in the pacemaker activity of sinus node in adult heart. Four subtypes of (HCN1-4), which encode I_f channel, have been identified. In the present study, we quantitatively estimated the expression of HCN1-4 mRNA in mouse ventricular myocardium 4 weeks after myocardial infarction (MI) by a real time PCR. In sham-operated control mice, HCN2 mRNA was expressed most abundantly (915.2±225.0molecules / 10^5 GAPDH molecules) in the ventricle . The expressions of mRNAs for HCN1, HCN3 and HCN4 were less abundant (15.2±5.0, 9.7±1.1, 48.2±25.3 molecules /10^5 GAPDH molecules respectively). In mice after MI, HCN2 mRNA increased significantly by 2.7 fold compared to controls. There was no significant difference of HCN1, HCN3 and HCN4 mRNA between two groups. There is an upregulation of HCN2 mRNA in compensated hypertrophied muscle in MI. This might be responsible for an enhancement of abnormal automaticity in the hearts after MI.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 国立情報学研究所で電子化したコンテンツを使用している。
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Research Institute of Environmental Medicine, Nagoya University
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/envm.46.89
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 02870517
書誌情報 en : Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University

巻 46, 号 1/2, p. 89-91, 発行日 2002-12
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/2794
識別子タイプ HDL
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