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Altered I_f Channel Gene Expression in Mouse Hearts after Myocardial Infarction
https://doi.org/10.18999/envm.46.89
https://doi.org/10.18999/envm.46.893e1a8a1c-6502-448a-98a5-ac291d9db7f0
名前 / ファイル | ライセンス | アクション |
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KJ00000034874.pdf (252.6 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-01-05 | |||||
タイトル | ||||||
タイトル | Altered I_f Channel Gene Expression in Mouse Hearts after Myocardial Infarction | |||||
言語 | en | |||||
著者 |
TAKEMURA, Haruki
× TAKEMURA, Haruki× NIWA, Noriko× HOJO, Mayumi× LEE, Jong-Kook× YASUI, Kenji× UEDA, Yuichi× KODAMA, Itsuo |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | I_f | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HCN gene | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mouse | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | myocardial infarction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hypertrophy | |||||
抄録 | ||||||
内容記述 | I_f channels play a key role in the pacemaker activity of sinus node in adult heart. Four subtypes of (HCN1-4), which encode I_f channel, have been identified. In the present study, we quantitatively estimated the expression of HCN1-4 mRNA in mouse ventricular myocardium 4 weeks after myocardial infarction (MI) by a real time PCR. In sham-operated control mice, HCN2 mRNA was expressed most abundantly (915.2±225.0molecules / 10^5 GAPDH molecules) in the ventricle . The expressions of mRNAs for HCN1, HCN3 and HCN4 were less abundant (15.2±5.0, 9.7±1.1, 48.2±25.3 molecules /10^5 GAPDH molecules respectively). In mice after MI, HCN2 mRNA increased significantly by 2.7 fold compared to controls. There was no significant difference of HCN1, HCN3 and HCN4 mRNA between two groups. There is an upregulation of HCN2 mRNA in compensated hypertrophied muscle in MI. This might be responsible for an enhancement of abnormal automaticity in the hearts after MI. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | 国立情報学研究所で電子化したコンテンツを使用している。 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Research Institute of Environmental Medicine, Nagoya University | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/envm.46.89 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 02870517 | |||||
書誌情報 |
en : Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University 巻 46, 号 1/2, p. 89-91, 発行日 2002-12 |
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フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/2794 | |||||
識別子タイプ | HDL |