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Dephosphorylation of Connexin43 Associated with Ventricular Hypertrophy
https://doi.org/10.18999/envm.46.106
https://doi.org/10.18999/envm.46.10662327b06-4453-4f38-95ce-a09b0deb4d6f
名前 / ファイル | ライセンス | アクション |
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KJ00000034880.pdf (471.0 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-01-05 | |||||
タイトル | ||||||
タイトル | Dephosphorylation of Connexin43 Associated with Ventricular Hypertrophy | |||||
言語 | en | |||||
著者 |
SASANO, Chieko
× SASANO, Chieko× UZZAMAN, Mahmud× EMDAD, Luni× TAKAGISHI, Yoshiko× HONJO, Haruo× KAMIYA, Kaichiro× KODAMA, Itsuo |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gap junction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | connexin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cardiac hypertrophy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dephosphorylation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | immunoblotting | |||||
抄録 | ||||||
内容記述 | Altered expression and distribution of gap junctions in hypertrophied hearts may provide a potential substrate for abnormal conduction. We investigated changes of phosphorylation state of connexin43 (Cx43) in hypertrophied rat right ventricles secondary to pulmonary hypertension induced by monocrotaline (MCT) using western blot analysis. In normal right ventricular myocardium, most of Cx43 was phosphorylated. In hypertrophied ventricles of MCT-treated rats, the non-phosphorylated isoform of Cx43 increased and the phosphorylated isoform of Cx43 decreased with no significant a change in the total amount of Cx43 protein. These results suggest that dephosphorylation of Cx43 in MCT-induced right ventricular hypertrophy may be involved in gap junction disorganization. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | 国立情報学研究所で電子化したコンテンツを使用している。 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Research Institute of Environmental Medicine, Nagoya University | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/envm.46.106 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 02870517 | |||||
書誌情報 |
en : Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University 巻 46, 号 1/2, p. 106-108, 発行日 2002-12 |
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フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/2800 | |||||
識別子タイプ | HDL |