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Evidence for Active Transport of 3H-Androgens Across the Epididymal Epithelium in the Rat
https://doi.org/10.18999/nagjms.56.1-4.111
https://doi.org/10.18999/nagjms.56.1-4.1117c04fbeb-f995-4e31-8a9e-7c458dad7321
名前 / ファイル | ライセンス | アクション |
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v56n14p111_121.pdf (621.3 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2012-02-08 | |||||
タイトル | ||||||
タイトル | Evidence for Active Transport of 3H-Androgens Across the Epididymal Epithelium in the Rat | |||||
言語 | en | |||||
著者 |
YAMAMOTO, MASANORI
× YAMAMOTO, MASANORI× TSUJI, YOSHIKAZU× MIYAKE, KOJI |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Active transport | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Androgen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Epididymis | |||||
抄録 | ||||||
内容記述 | The effect of metabolic inhibitors on transepithelial movement of 3H-androgens was investigated by in vivo perifusion and subsequent micropuncture of caput and cauda epididymal tubules. Epididymal tissue (adenosine triphosphate (ATP) concentrations were determined at 1 h after exposure of perifusion fluid with metabolic inhibitor. To determine whether or not metabolic inhibitor alters intraluminal androgen-binding protein concentration or androgen binding to interstitial proteins in the caput epididymis, 3H-dihydrotestosterone (DHT) binding to interaluminal androgen-binding protein and bound vs free androgen ratio in the interstitial fluid after 1 h perifusion with fluid containing metabolic inhibitor around caput epididymal tubules were examined. Proluminal movement of 3H-androgens and tissue ATP concentrations in the caput and cauda epididymis were significantly decreased by addition of dinitrophenol (DNP) or potassium cyanide to the perifusion fluid. Relative intraluminal androgen-binding protein protein concentration and bound vs free 3H-androgen ratio in the interstitial fluid were not altered when DNP or potassium cyanide was added to the perifusion fluid. These results demonstrate for the first time that an energy-dependent mechanism may be involved in the epididymal androgen uptake. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Nagoya University School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.56.1-4.111 | |||||
ID登録タイプ | JaLC | |||||
関連情報 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | URI | |||||
関連識別子 | https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5614/5614.html | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
en : Nagoya Journal of Medical Science 巻 56, 号 1-4, p. 111-121, 発行日 1993-11-25 |
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著者版フラグ | ||||||
値 | publisher |