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Beneficial Effects of Iloprost on Acute Myocardial Ischemia in Dogs
https://doi.org/10.18999/nagjms.57.1-2.25
https://doi.org/10.18999/nagjms.57.1-2.251fadd858-8c20-4065-a666-027a41096d0e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
v57n12p25_33.pdf (548.5 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-02-08 | |||||
| タイトル | ||||||
| タイトル | Beneficial Effects of Iloprost on Acute Myocardial Ischemia in Dogs | |||||
| 言語 | en | |||||
| 著者 |
IEDA, NOBUTO
× IEDA, NOBUTO× MATSUBARA, TATSUAKI× SAKAMOTO, NOBUO |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Iloprost | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Canine heart | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Ischemia | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Myocardial blood flow | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Myocardial energy metabolism | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The effects of intravenous administration of iloprost, a prostacyclin analogue, on myocardial energy metabolism and myocardial blood flow (MBF) were examined in anesthetized open-chest dogs subjected to 60 min of myocardial ischemia by coronary ligation. Iloprost administration at levels of 0.1 or 0.2 μg/kg/min was started 30 min before the commencement of ischemia and continued throughout the 90 min observation period. Since systolic aortic pressure in the iloprost 0.2 μg/kg/min group showed significantly lower values than that in the control group, whereas no clear effect was observed with the lower concentration (0.1 μg/kg/min), this latter group was further investigated. This 0.1 μg/kg/min dose of iloprost lacked influence on MBF in both ischemic and nonischemic areas but did result in a significantly higher value for high energy phosphate contents in the ischemic myocardium. Moreover, myocardial mitochondrial respiratory function in the ischemic area was significantly improved. These results indicate that iloprost brought about preservation of myocardial energy metabolism without alteration of coronary perfusion, suggesting that it may exert a direct cardioprotective effect. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 名古屋大学博士学位論文 学位の種類 : 博士(医学)(論文) 学位授与年月日:平成5年9月14日 家田信人氏の博士論文として提出された | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.57.1-2.25 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5712/5712.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 57, 号 1-2, p. 25-33, 発行日 1994-03-25 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
