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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 57(1-2)

Beneficial Effects of Iloprost on Acute Myocardial Ischemia in Dogs

https://doi.org/10.18999/nagjms.57.1-2.25
https://doi.org/10.18999/nagjms.57.1-2.25
1fadd858-8c20-4065-a666-027a41096d0e
名前 / ファイル ライセンス アクション
v57n12p25_33.pdf v57n12p25_33.pdf (548.5 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2012-02-08
タイトル
タイトル Beneficial Effects of Iloprost on Acute Myocardial Ischemia in Dogs
著者 IEDA, NOBUTO

× IEDA, NOBUTO

WEKO 98887

IEDA, NOBUTO

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MATSUBARA, TATSUAKI

× MATSUBARA, TATSUAKI

WEKO 98888

MATSUBARA, TATSUAKI

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SAKAMOTO, NOBUO

× SAKAMOTO, NOBUO

WEKO 98889

SAKAMOTO, NOBUO

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キーワード
主題Scheme Other
主題 Iloprost
キーワード
主題Scheme Other
主題 Canine heart
キーワード
主題Scheme Other
主題 Ischemia
キーワード
主題Scheme Other
主題 Myocardial blood flow
キーワード
主題Scheme Other
主題 Myocardial energy metabolism
抄録
内容記述 The effects of intravenous administration of iloprost, a prostacyclin analogue, on myocardial energy metabolism and myocardial blood flow (MBF) were examined in anesthetized open-chest dogs subjected to 60 min of myocardial ischemia by coronary ligation. Iloprost administration at levels of 0.1 or 0.2 μg/kg/min was started 30 min before the commencement of ischemia and continued throughout the 90 min observation period. Since systolic aortic pressure in the iloprost 0.2 μg/kg/min group showed significantly lower values than that in the control group, whereas no clear effect was observed with the lower concentration (0.1 μg/kg/min), this latter group was further investigated. This 0.1 μg/kg/min dose of iloprost lacked influence on MBF in both ischemic and nonischemic areas but did result in a significantly higher value for high energy phosphate contents in the ischemic myocardium. Moreover, myocardial mitochondrial respiratory function in the ischemic area was significantly improved. These results indicate that iloprost brought about preservation of myocardial energy metabolism without alteration of coronary perfusion, suggesting that it may exert a direct cardioprotective effect.
内容記述タイプ Abstract
内容記述
内容記述 名古屋大学博士学位論文 学位の種類 : 博士(医学)(論文) 学位授与年月日:平成5年9月14日 家田信人氏の博士論文として提出された
内容記述タイプ Other
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.57.1-2.25
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5712/5712.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 57, 号 1-2, p. 25-33, 発行日 1994-03-25
著者版フラグ
値 publisher
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