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Correlation between Myocardial Blood Flow and Tissue Succinate during Acute Ischemia
https://doi.org/10.18999/nagjms.57.1-2.43
https://doi.org/10.18999/nagjms.57.1-2.438b5fad6e-55ea-4cb3-a48e-2dcc06bbe853
名前 / ファイル | ライセンス | アクション |
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v57n12p43_50.pdf (505.6 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2012-02-08 | |||||
タイトル | ||||||
タイトル | Correlation between Myocardial Blood Flow and Tissue Succinate during Acute Ischemia | |||||
言語 | en | |||||
著者 |
KATO, KYOJI
× KATO, KYOJI× MATSUBARA, TATSUAKI× SAKAMOTO, NOBUO |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Myocardial ischemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Succinate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lactate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Myocardial blood flow | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Gas chromatograpfy-mass spectrometry | |||||
抄録 | ||||||
内容記述 | This study was performed to clarify the relationship between degree plus duration of myocardial ischemia and tissue succinate or lactate contents, and to assess whether their accumulation might be a metabolic marker of ischemic myocardium. Regional myocardial blood flow (MBF) was measured using the hydrogen gas clearance method in anesthetized open-chest dogs subjected to 10 min or 60 min of myocardial ischemia by coronary ligation. The contents of succinic acid and lactic acid in myocardium corresponding to locations of MBF measurement were quantitatively analyzed by gas chromatography-mass spectrometry. In severely ischemic areas with MBF less than 20 ml/min/100g, significant increases in both succinic and lactic acids were observed 10 min after coronary occlusion. Sixty min of ischemia induced significant increase in the myocardial succinic acid content not only in severely but also in moderately ischemic areas. In contrast, lactic acid was significantly increased only in the severely ischemic area 60 min after coronary occlusion. These results indicate a good correlation between degree plus duration of myocardial ischemia and tissue succinic acid content, suggesting that its accumulation in myocardium may be a reliable and sensitive metabolic marker of coronary ligation ischemia. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | 名古屋大学博士学位論文 学位の種類 : 博士(医学)(論文) 学位授与年月日:平成5年9月14日 加藤亨嗣氏の博士論文として提出された | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Nagoya University School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.57.1-2.43 | |||||
ID登録タイプ | JaLC | |||||
関連情報 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | URI | |||||
関連識別子 | https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5712/5712.html | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
en : Nagoya Journal of Medical Science 巻 57, 号 1-2, p. 43-50, 発行日 1994-03-25 |
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著者版フラグ | ||||||
値 | publisher |