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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 74(1-2)

PHYSIOLOGY AND PATHOPHYSIOLOGY OF BICARBONATE SECRETION BY PANCREATIC DUCT EPITHELIUM

https://doi.org/10.18999/nagjms.74.1-2.1
https://doi.org/10.18999/nagjms.74.1-2.1
a5b06d17-4313-403a-b6f6-c0f201c07d74
名前 / ファイル ライセンス アクション
01_Ishiguro.pdf 01_Ishiguro.pdf (12.6 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2012-02-28
タイトル
タイトル PHYSIOLOGY AND PATHOPHYSIOLOGY OF BICARBONATE SECRETION BY PANCREATIC DUCT EPITHELIUM
著者 ISHIGURO, HIROSHI

× ISHIGURO, HIROSHI

WEKO 43862

ISHIGURO, HIROSHI

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YAMAMOTO, AKIKO

× YAMAMOTO, AKIKO

WEKO 43863

YAMAMOTO, AKIKO

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NAKAKUKI, MIYUKI

× NAKAKUKI, MIYUKI

WEKO 43864

NAKAKUKI, MIYUKI

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YI, LANJUAN

× YI, LANJUAN

WEKO 43865

YI, LANJUAN

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ISHIGURO, MARIKO

× ISHIGURO, MARIKO

WEKO 43866

ISHIGURO, MARIKO

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YAMAGUCHI, MAKOTO

× YAMAGUCHI, MAKOTO

WEKO 43867

YAMAGUCHI, MAKOTO

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KONDO, SHIHO

× KONDO, SHIHO

WEKO 43868

KONDO, SHIHO

Search repository
MOCHIMARU, YUKA

× MOCHIMARU, YUKA

WEKO 43869

MOCHIMARU, YUKA

Search repository
キーワード
主題Scheme Other
主題 Isolated pancreatic duct
キーワード
主題Scheme Other
主題 CFTR
キーワード
主題Scheme Other
主題 Cystic fibrosis
キーワード
主題Scheme Other
主題 Alcoholic pancreatitis
抄録
内容記述 HCO3–-rich fluid in the pancreatic juice (2~3 L/day) is secreted by epithelial cells lining the pancreatic duct tree, while digestive enzymes are secreted by acinar cells with a small amount of Cl–-rich fluid. Ductal HCO3– secretion is not only regulated by gastrointestinal hormones and cholinergic nerves but is also influenced by luminal factors: intraductal pressure, Ca2+ concentration, pathological activation of protease and bile reflux. The maximum HCO3– concentration of the juice under secretin stimulation reaches 140–150 mM. Thus pancreatic duct cells secrete HCO3– against a ~7-fold concentration gradient. HCO3– secretion critically depends on the activity of CFTR, a cAMP-dependent anion channel localized in the apical membrane of various epithelia. In the proximal part of pancreatic ducts close to acinar cells HCO3– secretion across the apical membrane is largely mediated by SLC26A6 Cl–-HCO3– exchanger. In distal ducts where the luminal HCO3– concentration is already high, most of the HCO3– secretion is mediated by HCO3– conductance of CFTR. CFTR is the causative gene for cystic fibrosis. Loss of function due to severe mutations in both alleles causes typical cystic fibrosis characterized by dehydrated, thick, and viscous luminal fluid/mucus in the respiratory and gastrointestinal tract, pancreatic duct, and vas deferens. A compound heterozygote of mutations/polymorphisms (causing a mild dysfunction of CFTR) involves a risk of developing CFTR-related diseases such as chronic pancreatitis. In cystic fibrosis and certain cases of chronic pancreatitis, the pancreatic duct epithelium secretes a small amount of fluid with neutral~acidic pH, which causes an obstruction of the duct lumen by a protein plug or viscous mucus.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.74.1-2.1
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 74, 号 1-2, p. 1-18, 発行日 2012-02
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7412/7412.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/16018
識別子タイプ HDL
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