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PHYSIOLOGY AND PATHOPHYSIOLOGY OF BICARBONATE SECRETION BY PANCREATIC DUCT EPITHELIUM
https://doi.org/10.18999/nagjms.74.1-2.1
https://doi.org/10.18999/nagjms.74.1-2.1a5b06d17-4313-403a-b6f6-c0f201c07d74
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
01_Ishiguro.pdf (12.6 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-02-28 | |||||
| タイトル | ||||||
| タイトル | PHYSIOLOGY AND PATHOPHYSIOLOGY OF BICARBONATE SECRETION BY PANCREATIC DUCT EPITHELIUM | |||||
| 言語 | en | |||||
| 著者 |
ISHIGURO, HIROSHI
× ISHIGURO, HIROSHI× YAMAMOTO, AKIKO× NAKAKUKI, MIYUKI× YI, LANJUAN× ISHIGURO, MARIKO× YAMAGUCHI, MAKOTO× KONDO, SHIHO× MOCHIMARU, YUKA |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Isolated pancreatic duct | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CFTR | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cystic fibrosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Alcoholic pancreatitis | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | HCO3–-rich fluid in the pancreatic juice (2~3 L/day) is secreted by epithelial cells lining the pancreatic duct tree, while digestive enzymes are secreted by acinar cells with a small amount of Cl–-rich fluid. Ductal HCO3– secretion is not only regulated by gastrointestinal hormones and cholinergic nerves but is also influenced by luminal factors: intraductal pressure, Ca2+ concentration, pathological activation of protease and bile reflux. The maximum HCO3– concentration of the juice under secretin stimulation reaches 140–150 mM. Thus pancreatic duct cells secrete HCO3– against a ~7-fold concentration gradient. HCO3– secretion critically depends on the activity of CFTR, a cAMP-dependent anion channel localized in the apical membrane of various epithelia. In the proximal part of pancreatic ducts close to acinar cells HCO3– secretion across the apical membrane is largely mediated by SLC26A6 Cl–-HCO3– exchanger. In distal ducts where the luminal HCO3– concentration is already high, most of the HCO3– secretion is mediated by HCO3– conductance of CFTR. CFTR is the causative gene for cystic fibrosis. Loss of function due to severe mutations in both alleles causes typical cystic fibrosis characterized by dehydrated, thick, and viscous luminal fluid/mucus in the respiratory and gastrointestinal tract, pancreatic duct, and vas deferens. A compound heterozygote of mutations/polymorphisms (causing a mild dysfunction of CFTR) involves a risk of developing CFTR-related diseases such as chronic pancreatitis. In cystic fibrosis and certain cases of chronic pancreatitis, the pancreatic duct epithelium secretes a small amount of fluid with neutral~acidic pH, which causes an obstruction of the duct lumen by a protein plug or viscous mucus. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.74.1-2.1 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7412/7412.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 74, 号 1-2, p. 1-18, 発行日 2012-02 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/16018 | |||||
| 識別子タイプ | HDL | |||||
