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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 74(1-2)

DETERMINATION OF FERRITIN AND HEMOSIDERIN IRON IN PATIENTS WITH NORMAL IRON STORES AND IRON OVERLOAD BY SERUM FERRITIN KINETICS

https://doi.org/10.18999/nagjms.74.1-2.39
https://doi.org/10.18999/nagjms.74.1-2.39
b9f04095-f0ef-4a69-b903-bebc7369d906
名前 / ファイル ライセンス アクション
04_Saito.pdf 04_Saito.pdf (132.1 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2012-02-29
タイトル
タイトル DETERMINATION OF FERRITIN AND HEMOSIDERIN IRON IN PATIENTS WITH NORMAL IRON STORES AND IRON OVERLOAD BY SERUM FERRITIN KINETICS
著者 SAITO, HIROSHI

× SAITO, HIROSHI

WEKO 43875

SAITO, HIROSHI

Search repository
TOMITA, AKIHIRO

× TOMITA, AKIHIRO

WEKO 43876

TOMITA, AKIHIRO

Search repository
OHASHI, HARUHIKO

× OHASHI, HARUHIKO

WEKO 43877

OHASHI, HARUHIKO

Search repository
MAEDA, HIDEAKI

× MAEDA, HIDEAKI

WEKO 43878

MAEDA, HIDEAKI

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HAYASHI, HISAO

× HAYASHI, HISAO

WEKO 43879

HAYASHI, HISAO

Search repository
NAOE, TOMOKI

× NAOE, TOMOKI

WEKO 43880

NAOE, TOMOKI

Search repository
キーワード
主題Scheme Other
主題 Serum ferritin kinetics
キーワード
主題Scheme Other
主題 Determination of ferritin and hemosiderin
キーワード
主題Scheme Other
主題 Iron overload
キーワード
主題Scheme Other
主題 Chronic hepatitis C
キーワード
主題Scheme Other
主題 Storage iron metabolism
抄録
内容記述 We attempted to clarify the storage iron metabolism from the change in the serum ferritin level. We assumed that the nonlinear decrease in serum ferritin was caused by serum ferritin increase in iron mobilization. Under this assumption, we determined both ferritin and hemosiderin iron levels by computer-assisted simulation of the row of decreasing assay-dots of serum ferritin in 11 patients with normal iron stores free of both iron deficiency and iron overload; chronic hepatitis C (CHC) and iron deficiency anemia after treatment, and 11 patients with iron overload; hereditary hemochromatosis (HH) and transfusion-dependent anemias (TD). We determined the iron removal rates of 20 and 17 mg/day by administering mean doses of deferasirox at 631 and 616 mg/day in 2 TD during the period of balance of iron addition and removal as indicated by the serum ferritin returned to the previous level. The ferritin-per-hemosiderin ratio was almost the same in both HH and CHC. This matched the localized hepatic hemosiderin deposition in CHC with normal iron stores. We detected the ferritin increased by utilizing the hemosiderin iron in iron removal and the ferritin reduced by transforming ferritin into hemosiderin in iron additions. The iron storing capacity of hemosiderin was limitless, while that of ferritin was suppressed when ferritin iron exceeded around 5 grams. We confirmed the pathway of iron from hemosiderin to ferritin in iron mobilization, and that from ferritin to hemosiderin in iron deposition. Thus, serum ferritin kinetics enabled us to be the first to clinically clarify storage iron metabolism.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.74.1-2.39
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 74, 号 1-2, p. 39-49, 発行日 2012-02
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7412/7412.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/16021
識別子タイプ HDL
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