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A CASE OF PRIMARY GLUCOCORTICOID RESISTANCE
https://doi.org/10.18999/nagjms.58.3-4.143
https://doi.org/10.18999/nagjms.58.3-4.143e715ac35-eac7-4610-8c8d-7aa57c073f12
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
v58n34p143_147.pdf (328.3 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2012-03-08 | |||||
| タイトル | ||||||
| タイトル | A CASE OF PRIMARY GLUCOCORTICOID RESISTANCE | |||||
| 言語 | en | |||||
| 著者 |
KAWAKUBO, AKITOSHI
× KAWAKUBO, AKITOSHI× SUZUKI, ATSUSHI× YOKOI, HISASHI× KAKIYA, SATOSHI× MORIKAWA, MITSUYA× OISO, YUTAKA× YAMAMOTO, MASAHIRO |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Dexamethasone | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Glucocorticoid resistance | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Hypokalemia | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A 79-year-old woman developed hypokalemia and metabolic alkalosis after breast cancer surgery. She was suspected of having primary glucocorticoid resistance on the basis of high plasma ACTH and serum cortisol levels without the features of Cushing's syndrome. To clarify the end-organ resistance to cortisol, we characterized the glucocorticoid receptors (GR) in cultured skin fibroblasts from the patient. The GRs in whole cell assays decreased binding affinity (Kd = 11.1 +/- 0.6 nM) and the number of binding sites for [3H]dexamethasone (binding capacity was 15,600 +/- 1,255 sites per cell). These results strongly suggest that our patient had primary glucocorticoid resistance caused both by a decreased number of GRs and a reduction in the affinity of GRs to cortisol. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.58.3-4.143 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5834/5834.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 58, 号 3-4, p. 143-147, 発行日 1995-12-25 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/16090 | |||||
| 識別子タイプ | HDL | |||||
