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AN EVALUATION OF THE BIOLOGICAL EFFECTS OF THREE DIFFERENT MODES OF MAGNETIC FIELDS ON CULTURED MAMMALIAN CELLS
https://doi.org/10.18999/nagjms.58.3-4.157
https://doi.org/10.18999/nagjms.58.3-4.157d48aaa97-79dd-4f6e-8a42-6f6996bf89f4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
v58n34p157_164.pdf (950.1 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2012-03-08 | |||||
| タイトル | ||||||
| タイトル | AN EVALUATION OF THE BIOLOGICAL EFFECTS OF THREE DIFFERENT MODES OF MAGNETIC FIELDS ON CULTURED MAMMALIAN CELLS | |||||
| 言語 | en | |||||
| 著者 |
ZHANG, XIN RU
× ZHANG, XIN RU× KOBAYASHI, HIDETOSHI× HAYAKAWA, AKEMI× ISHIGAKI, TAKEO |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The biological effects of static magnetic fields, and their combined effects with ionizing radiation, were studied using a cultured mammalian cell line (FM3A). The three different modes of magnetic fields evaluated in this report were the 0.3 Tesla (T) field with a gradient of 0.3T/m, the 0.7T field with a gradient of 0.7T/m and the 6.34T field with no gradient. Exposure to the 0.3T and 0.7T fields had no effect on cell survival. Exposure to the 6.34T field decreased cell survival. Survival curves showing the combined effect of the 0.3T and 0.7T fields with radiation had a smaller mean lethal dose (D37) value. The survival curve of the 6.34T field was influenced by the interval between magnetic exposure and ionizing irradiation. When the interval was 6 or 12 h, the survival curve showing the combined effect of the 6.34T field had smaller D37 and quasithreshold dose (Dq) values, indicating the potentiation of the radiation effect. Flow cytometric analysis indicated that exposure to the 0.3T and 0.7T fields showed no change and that exposure to the 6.34T field showed an increase in the percentage of G1 phase cells. Our conclusions were as follows: 1) magnetic fields decreased the colony-forming abilities of cultured mammalian cells; 2) magnetic fields can affect the cell cycle; 3) a stronger magnetic field strength does not always have stronger biological effects and 4) the gradient of a magnetic field may be an important factor when combined with ionizing radiation. Despite the foregoing analysis, the biological effects of magnetic fields on mammalian cells remains a complex phenomena. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.58.3-4.157 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5834/5834.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 58, 号 3-4, p. 157-164, 発行日 1995-12-25 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/16092 | |||||
| 識別子タイプ | HDL | |||||
