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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 58(3-4)

THE CLINICAL AND HISTOPATHOLOGICAL EFFECTS OF COMBINED CHEMOTHERAPY USING CISPLATIN AND PEPLOMYCIN TO TREAT CANCER OF THE TONGUE

https://doi.org/10.18999/nagjms.58.3-4.171
https://doi.org/10.18999/nagjms.58.3-4.171
3f09d556-527c-4153-abb7-015beb0c8609
名前 / ファイル ライセンス アクション
v58n34p171_177.pdf v58n34p171_177.pdf (416.5 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2012-03-08
タイトル
タイトル THE CLINICAL AND HISTOPATHOLOGICAL EFFECTS OF COMBINED CHEMOTHERAPY USING CISPLATIN AND PEPLOMYCIN TO TREAT CANCER OF THE TONGUE
著者 TOHNAI, IWAI

× TOHNAI, IWAI

WEKO 44169

TOHNAI, IWAI

Search repository
HAYASHI, YASUSHI

× HAYASHI, YASUSHI

WEKO 44170

HAYASHI, YASUSHI

Search repository
YAMBE, MAKOTO

× YAMBE, MAKOTO

WEKO 44171

YAMBE, MAKOTO

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MITSUDO, KENJI

× MITSUDO, KENJI

WEKO 44172

MITSUDO, KENJI

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MIZUTANI, HIDEKI

× MIZUTANI, HIDEKI

WEKO 44173

MIZUTANI, HIDEKI

Search repository
UEDA, MINORU

× UEDA, MINORU

WEKO 44174

UEDA, MINORU

Search repository
キーワード
主題Scheme Other
主題 Cancer of the tongue
キーワード
主題Scheme Other
主題 Chemotherapy
キーワード
主題Scheme Other
主題 Cisplatin
キーワード
主題Scheme Other
主題 Peplomycin
キーワード
主題Scheme Other
主題 Histopathological effects
抄録
内容記述 Combined chemotherapy (PP therapy) using cisplatin (CDDP) and peplomycin (PEP) was performed as induction chemotherapy for 31 patients with cancer of the tongue, and the clinical and histopathological effects were investigated. As the primary clinical effect, complete response (CR) was observed in three cases, partial response (PR) in 20 cases, minor response (MR) in six cases and no change (NC) in two cases, with a clinical response rate of 74.2%. The histopathological effects of the chemotherapy in the following cases showed these histological Grades: 0 or I in four cases, IIa in 12 cases, IIb in eight cases, III in six cases and IV in one case. Fifteen of the 31 patients who received PP therapy showed a histological Grade of IIb or better, representing 48.4% of the histopathological response rate. With regard to the mode of invasion of the tumor, the histopathological response rate was 90.0% in patients with invasive Grades 1 and 2, 41.7% in those with invasive Grade 3 and 16.7% in those with invasive Grade 4C. There were no patients with invasive Grade 4D in whom the therapy was histopathologically effective. In other words, the histopathological effect significantly decreased as the invasive Grade increased. With regard to the relationship between clinical effects and histopathological effects, there was one CR patient who showed a histological Grade of IIa. Thus, it is noteworthy that clinical effects were not necessarily consistent with post-chemotherapeutic histopathological effects.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.58.3-4.171
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 58, 号 3-4, p. 171-177, 発行日 1995-12-25
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5834/5834.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/16094
識別子タイプ HDL
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