WEKO3
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Role of Nitric Oxide in the Cerebral Vasodilatory Responses to Vasopressin and Oxytocin in Dogs
http://hdl.handle.net/2237/16711
http://hdl.handle.net/2237/1671184b7bbf9-b59d-45bd-b6fb-beb827640d96
名前 / ファイル | ライセンス | アクション |
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k2839.pdf (1.8 MB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2012-08-20 | |||||
タイトル | ||||||
タイトル | Role of Nitric Oxide in the Cerebral Vasodilatory Responses to Vasopressin and Oxytocin in Dogs | |||||
言語 | en | |||||
著者 |
Oyama, Hirofumi
× Oyama, Hirofumi× Suzuki, Yoshio× Satoh, Shin-ichi× Kajita, Yasukazu× Takayasu, Masakazu× Shibuya, Masato× Sugita, Kenichiro |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | L-Arginine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Canine cerebral arteries | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | N^G-Monomethyl-L-arginine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Nitric Oxide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Oxytocin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Vasopressin | |||||
抄録 | ||||||
内容記述 | We angiographically assessed the vasodilatory effects of vasopressin and oxytocin on the basilar arteries in dogs. Intracisternal bolus injections of vasopressin (100 pmol and 1 nmol) and oxytocin (1 and 10 nmol) produced dose-dependent increases in the internal diameter of the basilar arteries without affecting mean arterial blood pressure. The maximal dilatations of the basilar arteries induced by 1 nmol vasopressin and 10 nmol oxytocin were 142.3 ± 19.9 and 136.8 ± 25.5% of the baseline, respectively. When the same peptides were injected into the vertebral artery, the maximal dilatations were similar, but the duration of response was shorter. Pretreatment with intracisternal injection of 10 µmol N^G-monomethyl-L-arginine (L-NMMA), which inhibits the synthesis of nitric oxide from L-arginine, suppressed the vasodilatory responses induced by intracisternal injection of vasopressin and oxytocin and by intraarterial injection of vasopressin. Calcitonin gene-related peptide also caused dilatation of the basilar artery when injected into the cisterna magna, but its effect was not blocked by L-NMMA. L-NMMA reduced the basal diameter of the basilar artery in a dose-dependent manner; L-arginine produced dose-dependent increases in diameter. The vasoconstriction induced by L-NMMA was reversed by high concentrations of L-arginine. These results suggest that vasopressin and oxytocin dilate the basilar arteries via the release of nitric oxide from both the intraluminal and the extraluminal sides and that synthesis and release of nitric oxide in the vascular wall contribute to maintenance of basal vascular tonus. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成5年5月14日 雄山博文氏の博士論文として提出された | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Nature Publishing Group | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_db06 | |||||
タイプ | doctoral thesis | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1038/jcbfm.1993.35 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0271-678X | |||||
書誌情報 |
en : Journal of Cerebral Blood Flow & Metabolism 巻 13, 号 2, p. 285-290, 発行日 1993-03 |
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学位名 | ||||||
言語 | ja | |||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 13901 | |||||
言語 | ja | |||||
学位授与機関名 | 名古屋大学 | |||||
言語 | en | |||||
学位授与機関名 | NAGOYA University | |||||
学位授与年度 | ||||||
学位授与年度 | 1992 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 1993-03-01 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第2839号 | |||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://dx.doi.org/10.1038/jcbfm.1993.35 | |||||
識別子タイプ | DOI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/16711 | |||||
識別子タイプ | HDL |