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  1. C100 医学部/医学系研究科
  2. C100d 学位論文
  3. 博士論文(医博・論医博)

Sympathetically induced paradoxical increases of the cutaneous blood flow in chronically inflamed rats

http://hdl.handle.net/2237/16719
http://hdl.handle.net/2237/16719
0313efe5-a213-4a88-8ed3-2d5dc68679eb
名前 / ファイル ライセンス アクション
o4963.pdf o4963.pdf (2.1 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2012-08-21
タイトル
タイトル Sympathetically induced paradoxical increases of the cutaneous blood flow in chronically inflamed rats
言語 en
著者 Tsujii, Yoichiro

× Tsujii, Yoichiro

WEKO 45663

en Tsujii, Yoichiro

Search repository
Koeda, Tomoko

× Koeda, Tomoko

WEKO 45664

en Koeda, Tomoko

Search repository
Sato, Jun

× Sato, Jun

WEKO 45665

en Sato, Jun

Search repository
Suzuki, Shigeyuki

× Suzuki, Shigeyuki

WEKO 45666

en Suzuki, Shigeyuki

Search repository
Kumazawa, Takao

× Kumazawa, Takao

WEKO 45667

en Kumazawa, Takao

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the author's version of a work that was accepted for publication in Journal of the Autonomic Nervous System. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of the Autonomic Nervous System. v.59, n.3, 1996, p.103–112 http://dx.doi.org/10.1016/0165-1838(96)00013-6
キーワード
主題Scheme Other
主題 Sympathetic nerve
キーワード
主題Scheme Other
主題 Vasodilatation
キーワード
主題Scheme Other
主題 Blood flow
キーワード
主題Scheme Other
主題 Laser-Doppler flowmeter
キーワード
主題Scheme Other
主題 Adjuvant arthritic rat
キーワード
主題Scheme Other
主題 Inflammation
キーワード
主題Scheme Other
主題 Nitric oxide
抄録
内容記述 In adjuvant arthritic (AA) rats, an abnormal responsiveness of nociceptors (C-fibre polymodal receptors) to sympathetic activities, i.e., α2-adrenoceptor mediated activation of C-fibre polymodal receptors (CPRs), has been observed. The present investigations were undertaken to determine if a similar plastic change would occur in the cutaneous vascular system in the rat chronic inflammation model. The vascular responses were measured by a laser-Doppler flowmeter in the hindpaw skin of the AA rats after electrical stimulation of lumbar sympathetic trunk (sympathetic stimulation). In control non-arthritic rats, the sympathetic stimulation caused decrease in blood flow of the skin (SkBF) in all animals tested (n = 7). On the other hand, the sympathetic stimulation in the AA rats caused both increase (n = 15) as well as decrease (n = 11) in SkBF. In contrast to the abnormal responsiveness of CPRs, the intra-arterial injection of noradrenaline caused the expected decrease in SkBF in all animals tested, and in no instances increases in SkBF were observed. To determine whether activation of nitric oxide (NO), which is known to be a potent endogenous vasodilatation substance, was involved in the vasodilating effect to sympathetic stimulation, an inhibitor of NO synthase, NG-monomethyl-L-arginine (L-NMMA), was applied systemically. L-NMMA significantly increased baseline blood pressure in the control and the AA rats, but it did not significantly alter the SkBF in the control or the AA rats after the sympathetic stimulation, suggesting the NO is not a mediator in the vasoactive responses. The results of the current studies showed for the first time that electrical stimulation of the lumbar sympathetic trunk causes vasodilatation in the skin of the AA rats. This abnormal responsiveness of regional SkBF after sympathetic stimulation was not mediated by adrenergic or NO system.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 名古屋大学博士学位論文 学位の種類 : 博士(医学)(論文) 学位授与年月日:平成8年3月8日 辻井洋一郎氏の博士論文として提出された
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/0165-1838(96)00013-6
ISSN
収録物識別子タイプ PISSN
収録物識別子 1566-0702
書誌情報 en : Journal of the Autonomic Nervous System

巻 59, 号 3, p. 103-112, 発行日 1996-07-05
学位名
言語 ja
学位名 博士(医学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13901
言語 ja
学位授与機関名 名古屋大学
言語 en
学位授与機関名 NAGOYA University
学位授与年度
学位授与年度 1996
学位授与年月日
学位授与年月日 1996-07-05
学位授与番号
学位授与番号 乙第4963号
著者版フラグ
値 publisher
URI
識別子 http://dx.doi.org/10.1016/0165-1838(96)00013-6
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/16719
識別子タイプ HDL
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