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  1. C100 医学部/医学系研究科
  2. C100d 学位論文
  3. 博士論文(医博・論医博)

ACTH Increases Expression of c-fos, c-jun and β-actin Genes in the Dexamethasone-treated Rat Adrenals

http://hdl.handle.net/2237/16720
http://hdl.handle.net/2237/16720
fb010ab0-dc10-4227-9ea4-b816ba5f8596
名前 / ファイル ライセンス アクション
o4245.pdf o4245.pdf (2.7 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2012-08-21
タイトル
タイトル ACTH Increases Expression of c-fos, c-jun and β-actin Genes in the Dexamethasone-treated Rat Adrenals
言語 en
著者 OHNO, MOTOTSUGU

× OHNO, MOTOTSUGU

WEKO 45668

en OHNO, MOTOTSUGU

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SEO, HISAO

× SEO, HISAO

WEKO 45669

en SEO, HISAO

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IMAI, TSUNEO

× IMAI, TSUNEO

WEKO 45670

en IMAI, TSUNEO

Search repository
MURATA, YOSHIHARU

× MURATA, YOSHIHARU

WEKO 45671

en MURATA, YOSHIHARU

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MIYAMOTO, NORIHIRO

× MIYAMOTO, NORIHIRO

WEKO 45672

en MIYAMOTO, NORIHIRO

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SATOH, YASUYUKI

× SATOH, YASUYUKI

WEKO 45673

en SATOH, YASUYUKI

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FUNAHASHI, HIROOMI

× FUNAHASHI, HIROOMI

WEKO 45674

en FUNAHASHI, HIROOMI

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TAKAGI, HIROSHI

× TAKAGI, HIROSHI

WEKO 45675

en TAKAGI, HIROSHI

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MATSUI, NOBUO

× MATSUI, NOBUO

WEKO 45676

en MATSUI, NOBUO

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 c-fos
キーワード
主題Scheme Other
主題 c-jun
キーワード
主題Scheme Other
主題 β-Actin
キーワード
主題Scheme Other
主題 Rat adrenal
キーワード
主題Scheme Other
主題 ACTH
抄録
内容記述 Our recent finding that ACTH increases c-fos mRNA in the adrenal gland of hypophysectomized rats indicates that the gene product FOS may play an important role (s) in mediating the action of ACTH. However, hypophysectomy employed in that study causes the disappearance of trophic hormones other than ACTH and may modify the effect of ACTH. Thus, in the present investigation, dexamethasone-treated rats were used. Since FOS functions only when it dimerizes with JUN (the product ofc-jun gene), the changes in the levels of c-fos and c-jun mRNAs were studied together with that of β-actin mRNA which is also affected by ACTH. Northern blot analysis was employed to determine the mRNA levels. It was demonstrated that ACTHincreases the mRNAs coding c-fos and c-jun in the adrenal glands of dexamethasone-treated, ACTH-suppressed rats. The c-fos mRNA was not detectable before ACTH administration. After ACTH administration, the mRNA levels were transiently increased, the maximum level being observed at 30min after ACTH. At 180min post ACTH, the level returned to the unstimulated level. The mRNA coding c-jun was detectable before ACTH administration and it also increased rapidly after ACTH with maximal stimulation at 30min. However, the mRNA level at 180min post ACTH was still higher than the unstimulated level. The changes in β-actin mRNA were approximately the same as those of c-jun mRNA. These results suggest that increased expression of c-fos, c-jun and β-actin genes by ACTH may play an important role in mediating its action on the adrenals.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 名古屋大学博士学位論文 学位の種類 : 医学博士(論文) 学位授与年月日:平成4年9月22日 大野元嗣氏の博士論文として提出された
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 The Japan Endocrine Society
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
ISSN
収録物識別子タイプ PISSN
収録物識別子 0013-7219
書誌情報 en : Endocrinologia Japonica

巻 39, 号 4, p. 377-383, 発行日 1992-08
学位名
言語 ja
学位名 博士(医学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13901
言語 ja
学位授与機関名 名古屋大学
言語 en
学位授与機関名 NAGOYA University
学位授与年度
学位授与年度 1992
学位授与年月日
学位授与年月日 1992-08-01
学位授与番号
学位授与番号 乙第4245号
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/16720
識別子タイプ HDL
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