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ACTH Increases Expression of c-fos, c-jun and β-actin Genes in the Dexamethasone-treated Rat Adrenals
http://hdl.handle.net/2237/16720
http://hdl.handle.net/2237/16720fb010ab0-dc10-4227-9ea4-b816ba5f8596
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
o4245.pdf (2.7 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-08-21 | |||||
| タイトル | ||||||
| タイトル | ACTH Increases Expression of c-fos, c-jun and β-actin Genes in the Dexamethasone-treated Rat Adrenals | |||||
| 言語 | en | |||||
| 著者 |
OHNO, MOTOTSUGU
× OHNO, MOTOTSUGU× SEO, HISAO× IMAI, TSUNEO× MURATA, YOSHIHARU× MIYAMOTO, NORIHIRO× SATOH, YASUYUKI× FUNAHASHI, HIROOMI× TAKAGI, HIROSHI× MATSUI, NOBUO |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | c-fos | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | c-jun | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | β-Actin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Rat adrenal | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ACTH | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Our recent finding that ACTH increases c-fos mRNA in the adrenal gland of hypophysectomized rats indicates that the gene product FOS may play an important role (s) in mediating the action of ACTH. However, hypophysectomy employed in that study causes the disappearance of trophic hormones other than ACTH and may modify the effect of ACTH. Thus, in the present investigation, dexamethasone-treated rats were used. Since FOS functions only when it dimerizes with JUN (the product ofc-jun gene), the changes in the levels of c-fos and c-jun mRNAs were studied together with that of β-actin mRNA which is also affected by ACTH. Northern blot analysis was employed to determine the mRNA levels. It was demonstrated that ACTHincreases the mRNAs coding c-fos and c-jun in the adrenal glands of dexamethasone-treated, ACTH-suppressed rats. The c-fos mRNA was not detectable before ACTH administration. After ACTH administration, the mRNA levels were transiently increased, the maximum level being observed at 30min after ACTH. At 180min post ACTH, the level returned to the unstimulated level. The mRNA coding c-jun was detectable before ACTH administration and it also increased rapidly after ACTH with maximal stimulation at 30min. However, the mRNA level at 180min post ACTH was still higher than the unstimulated level. The changes in β-actin mRNA were approximately the same as those of c-jun mRNA. These results suggest that increased expression of c-fos, c-jun and β-actin genes by ACTH may play an important role in mediating its action on the adrenals. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 名古屋大学博士学位論文 学位の種類 : 医学博士(論文) 学位授与年月日:平成4年9月22日 大野元嗣氏の博士論文として提出された | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | The Japan Endocrine Society | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0013-7219 | |||||
| 書誌情報 |
en : Endocrinologia Japonica 巻 39, 号 4, p. 377-383, 発行日 1992-08 |
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| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 13901 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 名古屋大学 | |||||
| 言語 | en | |||||
| 学位授与機関名 | NAGOYA University | |||||
| 学位授与年度 | ||||||
| 値 | 1992 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 1992-08-01 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 乙第4245号 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/16720 | |||||
| 識別子タイプ | HDL | |||||
