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Differing effects of vasopressin on regional cerebral blood flow of dogs following intracisternal vs. intra-arterial administration
http://hdl.handle.net/2237/16721
http://hdl.handle.net/2237/16721cc029f39-4283-4f9a-9539-c7aecf3b9323
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
k3020.pdf (709.2 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2012-08-22 | |||||
| タイトル | ||||||
| タイトル | Differing effects of vasopressin on regional cerebral blood flow of dogs following intracisternal vs. intra-arterial administration | |||||
| 言語 | en | |||||
| 著者 |
Tsugane, Shinichiro
× Tsugane, Shinichiro× Suzuki, Yoshio× Kano, Takahisa× Takayasu, Masakazu× Shibuya, Masato× Sugita, Kenichiro |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | This is the author's version of a work that was accepted for publication in Life Sciences. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Life Sciences. v.54, n.15, 1994, p.PL241–PL246 http://dx.doi.org/10.1016/0024-3205(94)00424-2 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We investigated the differential effect of the intracisternal and intraarterial administration of vasopressin on the regional cerebral blood flow (rCBF) in the parietal cortex of dogs. Regional CBF, velocity and blood volume were assayed by laser flowmetry. The intracisternal injection of 1 nmol vasopressin significantly increased the rCBF and velocity, without affecting blood volume. However, the intravertebral arterial injection of 1 nmol vasopressin significantly decreased the rCBF and velocity. This discrepancy can be explained by a difference in the affected vasculature; large blood vessels in the subarachnoid space vs. whole cerebral vascular system. The intracisternal and intraarterial injection of the nitric oxide inhibitor NG-monomethyl-L-arginine reduced the rCBF from the base line, and significantly suppressed the rCBF elevation induced by vasopressin. The effect of vasopressin may be considered as the summation of the increased flow from the dilated large vessels via the release of nitric oxide from the endothelium, and of the decreased flow from the contracted small vessels. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成6年3月25日 津金慎一郎氏の博士論文として提出された | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/0024-3205(94)00424-2 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0024-3205 | |||||
| 書誌情報 |
en : Life Sciences 巻 54, 号 15, p. PL241-PL246, 発行日 1994 |
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| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 13901 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 名古屋大学 | |||||
| 言語 | en | |||||
| 学位授与機関名 | NAGOYA University | |||||
| 学位授与年度 | ||||||
| 値 | 1993 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 1994-01-01 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第3020号 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://dx.doi.org/10.1016/0024-3205(94)00424-2 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/16721 | |||||
| 識別子タイプ | HDL | |||||
