{"_buckets": {"deposit": "b9844175-1883-43de-8876-9d1b3ad67668"}, "_deposit": {"id": "14789", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "14789"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00014789", "sets": ["1165"]}, "author_link": ["45683", "45684", "45685", "45686", "45687"], "item_12_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1994-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "49", "bibliographicPageStart": "43", "bibliographicVolumeNumber": "2", "bibliographic_titles": [{"bibliographic_title": "Osteoarthritis and Cartilage", "bibliographic_titleLang": "en"}]}]}, "item_12_date_granted_64": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "1994-03-01"}]}, "item_12_degree_grantor_62": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_language": "ja", "subitem_degreegrantor_name": "名古屋大学"}, {"subitem_degreegrantor_language": "en", "subitem_degreegrantor_name": "NAGOYA University"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "13901", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_12_degree_name_61": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)", "subitem_degreename_language": "ja"}]}, "item_12_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The expression of PG-M in osteoarthritic cartilage was investigated. Cartilage from five hip joints with osteoarthritis (OA) and control cartilage from five knee joints with post-traumatic injury were obtained and analyzed with anti-PG-M antibodies. Control cartilage showed no staining, but in osteoarthritic cartilage there was strong staining of the cytoplasm of chondrocytes with abnormal morphology. The cytoplasm of inflammatory cells invading the osteoarthritic cartilage matrix was also strongly stained which led to determining the sequence of PG-M core protein. The deduced amino acid sequence and homology analysis indicated that PG-M had a complement regulatory protein-like domain, a lectin-like domain, two EGF-like domains from the carboxyl-terminal with an extremely high homology to the respective domains of versican, a large proteoglycan expressed by human fibroblasts. The anti-PG-M antibodies cross-reacted with Ver-27b fusion protein which was expressed by a cDNA clone coding the N-terminal portion of versican core protein. Thus, the immunological and sequencing data suggest that PG-M is a molecule similar to or identical with human versican, and that the material in cartilage reactive to the anti-PG-M antibodies is versican. These findings suggest the PG-M/versican is expressed in osteoarthritic cartilage.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_12_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成6年4月5日 西田佳弘氏の博士論文として提出された", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_12_dissertation_number_65": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲第3024号"}]}, "item_12_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "DOI", "subitem_identifier_uri": "http://dx.doi.org/10.1016/S1063-4584(05)80005-6"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/16722"}]}, "item_12_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier", "subitem_publisher_language": "en"}]}, "item_12_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/S1063-4584(05)80005-6", "subitem_relation_type_select": "DOI"}}]}, "item_12_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This is the author\u0027s version of a work that was accepted for publication in Osteoarthritis and Cartilage. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Osteoarthritis and Cartilage. v.2, n.1, 1994, p.43–49 http://dx.doi.org/10.1016/S1063-4584(05)80005-6", "subitem_rights_language": "en"}]}, "item_12_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_12_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1063-4584", "subitem_source_identifier_type": "PISSN"}]}, "item_12_text_63": {"attribute_name": "学位授与年度", "attribute_value_mlt": [{"subitem_text_value": "1993"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nishida, Yoshihiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "45683", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shinomura, Tamayuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "45684", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iwata, Hisashi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "45685", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miura, Takayuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "45686", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimata, Koji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "45687", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "k3024.pdf", "filesize": [{"value": "3.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 3300000.0, "url": {"label": "k3024.pdf", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/14789/files/k3024.pdf"}, "version_id": "925eb719-21c8-4244-bc9a-db30914f0bd8"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Osteoarthritic cartilage", "subitem_subject_scheme": "Other"}, {"subitem_subject": "PG-M, Versican", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Chondroitin sulfate proteoglycan", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Abnormal occurrence of a large chondroitin sulfate proteoglycan, PG-M/versican in osteoarthritic cartilage", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Abnormal occurrence of a large chondroitin sulfate proteoglycan, PG-M/versican in osteoarthritic cartilage", "subitem_title_language": "en"}]}, "item_type_id": "12", "owner": "1", "path": ["1165"], "permalink_uri": "http://hdl.handle.net/2237/16722", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2012-08-22"}, "publish_date": "2012-08-22", "publish_status": "0", "recid": "14789", "relation": {}, "relation_version_is_last": true, "title": ["Abnormal occurrence of a large chondroitin sulfate proteoglycan, PG-M/versican in osteoarthritic cartilage"], "weko_shared_id": -1}