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  1. C100 医学部/医学系研究科
  2. C100d 学位論文
  3. 博士論文(医博・論医博)

Abnormal occurrence of a large chondroitin sulfate proteoglycan, PG-M/versican in osteoarthritic cartilage

http://hdl.handle.net/2237/16722
http://hdl.handle.net/2237/16722
f329b7d4-3514-4921-aef9-2e60804da7c2
名前 / ファイル ライセンス アクション
k3024.pdf k3024.pdf (3.3 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2012-08-22
タイトル
タイトル Abnormal occurrence of a large chondroitin sulfate proteoglycan, PG-M/versican in osteoarthritic cartilage
言語 en
著者 Nishida, Yoshihiro

× Nishida, Yoshihiro

WEKO 45683

en Nishida, Yoshihiro

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Shinomura, Tamayuki

× Shinomura, Tamayuki

WEKO 45684

en Shinomura, Tamayuki

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Iwata, Hisashi

× Iwata, Hisashi

WEKO 45685

en Iwata, Hisashi

Search repository
Miura, Takayuki

× Miura, Takayuki

WEKO 45686

en Miura, Takayuki

Search repository
Kimata, Koji

× Kimata, Koji

WEKO 45687

en Kimata, Koji

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the author's version of a work that was accepted for publication in Osteoarthritis and Cartilage. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Osteoarthritis and Cartilage. v.2, n.1, 1994, p.43–49 http://dx.doi.org/10.1016/S1063-4584(05)80005-6
キーワード
主題Scheme Other
主題 Osteoarthritic cartilage
キーワード
主題Scheme Other
主題 PG-M, Versican
キーワード
主題Scheme Other
主題 Chondroitin sulfate proteoglycan
抄録
内容記述 The expression of PG-M in osteoarthritic cartilage was investigated. Cartilage from five hip joints with osteoarthritis (OA) and control cartilage from five knee joints with post-traumatic injury were obtained and analyzed with anti-PG-M antibodies. Control cartilage showed no staining, but in osteoarthritic cartilage there was strong staining of the cytoplasm of chondrocytes with abnormal morphology. The cytoplasm of inflammatory cells invading the osteoarthritic cartilage matrix was also strongly stained which led to determining the sequence of PG-M core protein. The deduced amino acid sequence and homology analysis indicated that PG-M had a complement regulatory protein-like domain, a lectin-like domain, two EGF-like domains from the carboxyl-terminal with an extremely high homology to the respective domains of versican, a large proteoglycan expressed by human fibroblasts. The anti-PG-M antibodies cross-reacted with Ver-27b fusion protein which was expressed by a cDNA clone coding the N-terminal portion of versican core protein. Thus, the immunological and sequencing data suggest that PG-M is a molecule similar to or identical with human versican, and that the material in cartilage reactive to the anti-PG-M antibodies is versican. These findings suggest the PG-M/versican is expressed in osteoarthritic cartilage.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成6年4月5日 西田佳弘氏の博士論文として提出された
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/S1063-4584(05)80005-6
ISSN
収録物識別子タイプ PISSN
収録物識別子 1063-4584
書誌情報 en : Osteoarthritis and Cartilage

巻 2, 号 1, p. 43-49, 発行日 1994-03
学位名
言語 ja
学位名 博士(医学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13901
言語 ja
学位授与機関名 名古屋大学
言語 en
学位授与機関名 NAGOYA University
学位授与年度
学位授与年度 1993
学位授与年月日
学位授与年月日 1994-03-01
学位授与番号
学位授与番号 甲第3024号
著者版フラグ
値 publisher
URI
識別子 http://dx.doi.org/10.1016/S1063-4584(05)80005-6
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/16722
識別子タイプ HDL
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