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  1. C100 医学部/医学系研究科
  2. C100d 学位論文
  3. 博士論文(医博・論医博)

Mucosal Interleukin-8 is Involved in Neutrophil Migration and Binding to Extracellular Matrix in Inflammatory Bowel Disease

http://hdl.handle.net/2237/16733
http://hdl.handle.net/2237/16733
77d3bfce-bb31-4d05-bcd7-eb96e990f59c
名前 / ファイル ライセンス アクション
k3815.pdf k3815.pdf (1.1 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2012-08-29
タイトル
タイトル Mucosal Interleukin-8 is Involved in Neutrophil Migration and Binding to Extracellular Matrix in Inflammatory Bowel Disease
言語 en
著者 Ina, Kenji

× Ina, Kenji

WEKO 45716

en Ina, Kenji

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Kusugami, Kazuo

× Kusugami, Kazuo

WEKO 45717

en Kusugami, Kazuo

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Yamaguchi, Takeo

× Yamaguchi, Takeo

WEKO 45718

en Yamaguchi, Takeo

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Imada, Akira

× Imada, Akira

WEKO 45719

en Imada, Akira

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Hosokawa, Takehiko

× Hosokawa, Takehiko

WEKO 45720

en Hosokawa, Takehiko

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Ohsuga, Masahiro

× Ohsuga, Masahiro

WEKO 45721

en Ohsuga, Masahiro

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Shinoda, Masataka

× Shinoda, Masataka

WEKO 45722

en Shinoda, Masataka

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Ando, Takafumi

× Ando, Takafumi

WEKO 45723

en Ando, Takafumi

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Ito, Katsuki

× Ito, Katsuki

WEKO 45724

en Ito, Katsuki

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Yokoyama, Yasuhisa

× Yokoyama, Yasuhisa

WEKO 45725

en Yokoyama, Yasuhisa

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the author's version of a work accepted for publication by Elsevier. Changes resulting from the publishing process, including peer review, editing, corrections, structural formatting and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. The definitive version has been published in The American Journal of Gastroenterology. v.92, n.8, 1997, p.1342-1346
抄録
内容記述 OBJECTIVES:In this study, our purpose was to determine whether locally generated interleukin-8 (IL-8) is involved in neutrophil migration and binding to extracellular matrix, using the colonic mucosal specimens obtained from patients with inflammatory bowel disease (IBD). METHODS:Levels of IL-8 secreted in the organ cultures were measured by enzyme-linked immunosorbent assay. Chemotactic activity and binding capacity of neutrophils were induced by the organ culture supernatants. RESULTS:Significantly higher levels of IL-8 were secreted in patients with IBD, and its elevation was more prominent in patients with active ulcerative colitis. The organ culture supernatants induced higher chemotactic activity and binding capacity of neutrophils in patients with IBD, especially in those with active ulcerative colitis, compared with controls. These effects were inhibited significantly when the supernatants were submitted to preincubation with neutralizing anti-IL-8 antibody. CONCLUSIONS:Increased mucosal generation of IL-8 may attract neutrophils from the circulation into the inflammatory site and induce binding of neutrophils in the interstitial tissue, contributing to accumulation and activation of neutrophils in the affected mucosa with IBD.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成9年9月12日 伊奈研次氏の博士論文として提出された
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
ISSN
収録物識別子タイプ PISSN
収録物識別子 0002-9270
書誌情報 en : The American Journal of Gastroenterology

巻 92, 号 8, p. 1342-1346, 発行日 1997-08
学位名
言語 ja
学位名 博士(医学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13901
言語 ja
学位授与機関名 名古屋大学
言語 en
学位授与機関名 NAGOYA University
学位授与年度
学位授与年度 1997
学位授与年月日
学位授与年月日 1997-08-01
学位授与番号
学位授与番号 甲第3815号
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/16733
識別子タイプ HDL
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