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Mucosal Interleukin-8 is Involved in Neutrophil Migration and Binding to Extracellular Matrix in Inflammatory Bowel Disease
http://hdl.handle.net/2237/16733
http://hdl.handle.net/2237/1673377d3bfce-bb31-4d05-bcd7-eb96e990f59c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
k3815.pdf (1.1 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2012-08-29 | |||||
| タイトル | ||||||
| タイトル | Mucosal Interleukin-8 is Involved in Neutrophil Migration and Binding to Extracellular Matrix in Inflammatory Bowel Disease | |||||
| 言語 | en | |||||
| 著者 |
Ina, Kenji
× Ina, Kenji× Kusugami, Kazuo× Yamaguchi, Takeo× Imada, Akira× Hosokawa, Takehiko× Ohsuga, Masahiro× Shinoda, Masataka× Ando, Takafumi× Ito, Katsuki× Yokoyama, Yasuhisa |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | This is the author's version of a work accepted for publication by Elsevier. Changes resulting from the publishing process, including peer review, editing, corrections, structural formatting and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. The definitive version has been published in The American Journal of Gastroenterology. v.92, n.8, 1997, p.1342-1346 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | OBJECTIVES:In this study, our purpose was to determine whether locally generated interleukin-8 (IL-8) is involved in neutrophil migration and binding to extracellular matrix, using the colonic mucosal specimens obtained from patients with inflammatory bowel disease (IBD). METHODS:Levels of IL-8 secreted in the organ cultures were measured by enzyme-linked immunosorbent assay. Chemotactic activity and binding capacity of neutrophils were induced by the organ culture supernatants. RESULTS:Significantly higher levels of IL-8 were secreted in patients with IBD, and its elevation was more prominent in patients with active ulcerative colitis. The organ culture supernatants induced higher chemotactic activity and binding capacity of neutrophils in patients with IBD, especially in those with active ulcerative colitis, compared with controls. These effects were inhibited significantly when the supernatants were submitted to preincubation with neutralizing anti-IL-8 antibody. CONCLUSIONS:Increased mucosal generation of IL-8 may attract neutrophils from the circulation into the inflammatory site and induce binding of neutrophils in the interstitial tissue, contributing to accumulation and activation of neutrophils in the affected mucosa with IBD. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成9年9月12日 伊奈研次氏の博士論文として提出された | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0002-9270 | |||||
| 書誌情報 |
en : The American Journal of Gastroenterology 巻 92, 号 8, p. 1342-1346, 発行日 1997-08 |
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| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 13901 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 名古屋大学 | |||||
| 言語 | en | |||||
| 学位授与機関名 | NAGOYA University | |||||
| 学位授与年度 | ||||||
| 値 | 1997 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 1997-08-01 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第3815号 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/16733 | |||||
| 識別子タイプ | HDL | |||||
