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In order to investigate the polymorphic backgrounds of CFTR genes of healthy populations in different Chinese cities (Changchun and Nanjing), we analyzed 119 blood samples (Changchun 64, Nanjing 55) of randomly selected healthy individuals for poly T, TG-repeats and M470V polymorphisms. We analyzed the differences of CFTR polymorphic distributions between the two Chinese cities from the south and the north. Methods Genomic DNA was extracted from whole blood. DNA fragments of CFTR gene were amplified by polymerase chain reaction (PCR). Poly-T and TG repeats were directly sequenced by auto sequencer (ABI 310). M470V was detected by a HphI restriction enzyme. Results The T7 allele was the most common haplotype in Changchun (0.938) and Nanjing (0.927) populations. The T5 allele was present in only 7 Changchun and 3 Nanjing subjects. The TG11 and TG12 alleles were dominant haplotypes in Changchun (TG11 0.500, TG12 0.453) and Nanjing (TG11 0.345, TG12 0.609). 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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 74(3-4)

CFTR POLYMORPHISMS OF HEALTHY INDIVIDUALS IN TWO CHINESE CITIES : CHANGCHUN AND NANJING

https://doi.org/10.18999/nagjms.74.3-4.293
https://doi.org/10.18999/nagjms.74.3-4.293
5a37f1de-9ec7-44e9-a588-9237f13da0e0
名前 / ファイル ライセンス アクション
08_Chun.pdf 08_Chun.pdf (173.3 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2012-08-29
タイトル
タイトル CFTR POLYMORPHISMS OF HEALTHY INDIVIDUALS IN TWO CHINESE CITIES : CHANGCHUN AND NANJING
著者 JIN, CHUN XIANG

× JIN, CHUN XIANG

WEKO 45772

JIN, CHUN XIANG

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FUJIKI, KOTOYO

× FUJIKI, KOTOYO

WEKO 45773

FUJIKI, KOTOYO

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SONG, YING

× SONG, YING

WEKO 45774

SONG, YING

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PING, ZHANG

× PING, ZHANG

WEKO 45775

PING, ZHANG

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NAKAKUKI, MIYUKI

× NAKAKUKI, MIYUKI

WEKO 45776

NAKAKUKI, MIYUKI

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WEI, MU XIN

× WEI, MU XIN

WEKO 45777

WEI, MU XIN

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ZHANG, SU MIN

× ZHANG, SU MIN

WEKO 45778

ZHANG, SU MIN

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ISHIGURO, HIROSHI

× ISHIGURO, HIROSHI

WEKO 45779

ISHIGURO, HIROSHI

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NARUSE, SATORU

× NARUSE, SATORU

WEKO 45780

NARUSE, SATORU

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キーワード
主題Scheme Other
主題 CFTR
キーワード
主題Scheme Other
主題 Polymorphisms
キーワード
主題Scheme Other
主題 Poly-T
キーワード
主題Scheme Other
主題 TG repeats
キーワード
主題Scheme Other
主題 Chinese
抄録
内容記述 Background and Aim Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encodes a chloride channel, cause cystic fibrosis. In order to investigate the polymorphic backgrounds of CFTR genes of healthy populations in different Chinese cities (Changchun and Nanjing), we analyzed 119 blood samples (Changchun 64, Nanjing 55) of randomly selected healthy individuals for poly T, TG-repeats and M470V polymorphisms. We analyzed the differences of CFTR polymorphic distributions between the two Chinese cities from the south and the north. Methods Genomic DNA was extracted from whole blood. DNA fragments of CFTR gene were amplified by polymerase chain reaction (PCR). Poly-T and TG repeats were directly sequenced by auto sequencer (ABI 310). M470V was detected by a HphI restriction enzyme. Results The T7 allele was the most common haplotype in Changchun (0.938) and Nanjing (0.927) populations. The T5 allele was present in only 7 Changchun and 3 Nanjing subjects. The TG11 and TG12 alleles were dominant haplotypes in Changchun (TG11 0.500, TG12 0.453) and Nanjing (TG11 0.345, TG12 0.609). The frequency of the V470 allele was 0.633 in Changchun, which was higher than that in Nanjing (0.500) (p<0.05). There were three major haplotypes: T7-TG11-V470, T7-TG12-M470 and T7-TG12-V470. The T7-TG11-V470 was the most common haplotype in Changchun (0.514), while T7-TG12-M470 was the most common haplotype in Nanjing (0.500). Conclusion Though Changchun and Nanjing are in the same country, their polymorphic backgrounds of CFTR gene are very different. Most of the two populations have genotypes that cause lower CFTR function.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.74.3-4.293
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 74, 号 3-4, p. 293-302, 発行日 2012-08
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7434/7434.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/16740
識別子タイプ HDL
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