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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 74(3-4)

RESTRICTED EXPRESSION OF NEW GUANINE NUCLEOTIDE EXCHANGE FACTOR ZIZIMIN2 IN AGED ACQUIRED IMMUNE SYSTEM

https://doi.org/10.18999/nagjms.74.3-4.303
https://doi.org/10.18999/nagjms.74.3-4.303
fa82de66-8052-420d-b4a9-aed4bf464297
名前 / ファイル ライセンス アクション
09_Jia.pdf 09_Jia.pdf (569.3 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2012-08-29
タイトル
タイトル RESTRICTED EXPRESSION OF NEW GUANINE NUCLEOTIDE EXCHANGE FACTOR ZIZIMIN2 IN AGED ACQUIRED IMMUNE SYSTEM
著者 JIA, YANJUN

× JIA, YANJUN

WEKO 45781

JIA, YANJUN

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SAKABE, ISAMU

× SAKABE, ISAMU

WEKO 45782

SAKABE, ISAMU

Search repository
MATSUDA, TAKENORI

× MATSUDA, TAKENORI

WEKO 45783

MATSUDA, TAKENORI

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HAYAKAWA, TOMOKO

× HAYAKAWA, TOMOKO

WEKO 45784

HAYAKAWA, TOMOKO

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MARUYAMA, MITSUO

× MARUYAMA, MITSUO

WEKO 45785

MARUYAMA, MITSUO

Search repository
キーワード
主題Scheme Other
主題 Zizimin2
キーワード
主題Scheme Other
主題 Guanine nucleotide exchange factor
キーワード
主題Scheme Other
主題 Immunosenescence
キーワード
主題Scheme Other
主題 Aging
抄録
内容記述 The activity of various biological functions, such as nervous, endocrine and immune systems including acquired immunity, is known to decline along with aging. To elucidate the molecular mechanism of this phenomenon, we here compared the number of thymocytes, splenocytes, and bone marrow lymphocytes in young and aged mice and found the age-related functional fragility of the immune system. However, the molecular mechanisms or even the key molecules remain elusive. Therefore, we further focused on a candidate for immunosenesence-related molecules, Zizimin2, which we have recently isolated and identified as a novel guanine nucleotide exchange factor that is highly expressed in murine splenic germinal center B cells after immunization with a T cell-dependent antigen. Here, we showed that endogenous Zizimin2 protein as well as mRNA expression levels in immune organs are strictly suppressed in aged mice. We further observed that the serum antigen specific antibody response is hampered in aged mice compared to that in young animals. Moreover, the Zizimin2 mRNA expression level was not activated after immunization in aged mice. Taken together, these data suggested that Zizimin2 is associated with the reduction of immune response in acquired immunity along with aging.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.74.3-4.303
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 74, 号 3-4, p. 303-311, 発行日 2012-08
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7434/7434.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/16741
識別子タイプ HDL
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