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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 65(3-4)

Functional Activation of Peroxisome Proliferator-Activated Receptor α (PPARα) by Environmental Chemicals in Relation to Their Toxicities

https://doi.org/10.18999/nagjms.65.3-4.85
https://doi.org/10.18999/nagjms.65.3-4.85
82ec26c5-9530-4788-9353-c0d5361148e9
名前 / ファイル ライセンス アクション
v65n34p85_94.pdf v65n34p85_94.pdf (60.8 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2012-08-30
タイトル
タイトル Functional Activation of Peroxisome Proliferator-Activated Receptor α (PPARα) by Environmental Chemicals in Relation to Their Toxicities
著者 NAKAJIMA, TAMIE

× NAKAJIMA, TAMIE

WEKO 45842

NAKAJIMA, TAMIE

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ICHIHARA, GAKU

× ICHIHARA, GAKU

WEKO 45843

ICHIHARA, GAKU

Search repository
KAMIJIMA, MICHIHIRO

× KAMIJIMA, MICHIHIRO

WEKO 45844

KAMIJIMA, MICHIHIRO

Search repository
ITOHARA, SEIICHIRO

× ITOHARA, SEIICHIRO

WEKO 45845

ITOHARA, SEIICHIRO

Search repository
AOYAMA, TOSHIFUMI

× AOYAMA, TOSHIFUMI

WEKO 45846

AOYAMA, TOSHIFUMI

Search repository
キーワード
主題Scheme Other
主題 herbicides
キーワード
主題Scheme Other
主題 organic solvents
キーワード
主題Scheme Other
主題 peroxisome proliferator-activated receptor (PPARα)
キーワード
主題Scheme Other
主題 plasticizers plasticizers
キーワード
主題Scheme Other
主題 transcriptional activation
抄録
内容記述 Peroxisome proliferator-activated receptor α (PPARα) may work in the processes of both physiological and toxicological response to various endogenous or exogenous substances. The literature on the study of functional activation of PPARα by environmental chemicals in relation to their toxicities were reviewed. Environmental chemicals that were found to induce peroxisomes (peroxisome proliferators) and to activate the function of PPARα included plasticizers, herbicides, and organic solvents that have carboxyl groups in their parent substances or their metabolites. Several studies have showed species differences in the constitutive expression of PPARα and activation of PPARα, which may result in species differences in the induction of transcription of the genes encoding several peroxisomal enzymes. Although much information has supported the view that PPARα is primarily involved in the hepatic carcinogenicity of peroxisome proliferators, conflicting evidence exists. Most of the peroxisome proliferators have been shown to induce reproductive and developmental disorders, which might, in part. be associated with the functional activation of PPARα. Few epidemiological studies on the effect of peroxisome proliferators on humans have been conducted. The effect of perfluorooctanoic acid on humans was evaluated from the aspect of lipid metabolism in one study, which concluded that there was no effect.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.65.3-4.85
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 65, 号 3-4, p. 85-94, 発行日 2002-11
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/6534/6534.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/16763
識別子タイプ HDL
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