{"_buckets": {"deposit": "54ce6136-c473-4e88-8614-decc09f356b1"}, "_deposit": {"id": "14830", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "14830"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00014830"}, "item_9_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2002-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3-4", "bibliographicPageEnd": "94", "bibliographicPageStart": "85", "bibliographicVolumeNumber": "65", "bibliographic_titles": [{"bibliographic_title": "Nagoya Journal of Medical Science"}]}]}, "item_9_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Peroxisome proliferator-activated receptor \u03b1 (PPAR\u03b1) may work in the processes of both physiological and toxicological response to various endogenous or exogenous substances. The literature on the study of functional activation of PPAR\u03b1 by environmental chemicals in relation to their toxicities were reviewed. Environmental chemicals that were found to induce peroxisomes (peroxisome proliferators) and to activate the function of PPAR\u03b1 included plasticizers, herbicides, and organic solvents that have carboxyl groups in their parent substances or their metabolites. Several studies have showed species differences in the constitutive expression of PPAR\u03b1 and activation of PPAR\u03b1, which may result in species differences in the induction of transcription of the genes encoding several peroxisomal enzymes. Although much information has supported the view that PPAR\u03b1 is primarily involved in the hepatic carcinogenicity of peroxisome proliferators, conflicting evidence exists. Most of the peroxisome proliferators have been shown to induce reproductive and developmental disorders, which might, in part. be associated with the functional activation of PPAR\u03b1. Few epidemiological studies on the effect of peroxisome proliferators on humans have been conducted. The effect of perfluorooctanoic acid on humans was evaluated from the aspect of lipid metabolism in one study, which concluded that there was no effect.", "subitem_description_type": "Abstract"}]}, "item_9_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "URI", "subitem_identifier_uri": "http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/6534/6534.html"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/16763"}]}, "item_9_identifier_registration": {"attribute_name": "ID\u767b\u9332", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.65.3-4.85", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University School of Medicine"}]}, "item_9_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_7": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "0027-7622", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "NAKAJIMA, TAMIE"}], "nameIdentifiers": [{"nameIdentifier": "45842", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ICHIHARA, GAKU"}], "nameIdentifiers": [{"nameIdentifier": "45843", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KAMIJIMA, MICHIHIRO"}], "nameIdentifiers": [{"nameIdentifier": "45844", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ITOHARA, SEIICHIRO"}], "nameIdentifiers": [{"nameIdentifier": "45845", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "AOYAMA, TOSHIFUMI"}], "nameIdentifiers": [{"nameIdentifier": "45846", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "v65n34p85_94.pdf", "filesize": [{"value": "60.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 60800.0, "url": {"label": "v65n34p85_94.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/14830/files/v65n34p85_94.pdf"}, "version_id": "1a4a12a3-f574-4e69-9b5d-8088dedee329"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "herbicides", "subitem_subject_scheme": "Other"}, {"subitem_subject": "organic solvents", "subitem_subject_scheme": "Other"}, {"subitem_subject": "peroxisome proliferator-activated receptor (PPAR\u03b1)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "plasticizers plasticizers", "subitem_subject_scheme": "Other"}, {"subitem_subject": "transcriptional activation", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Functional Activation of Peroxisome Proliferator-Activated Receptor \u03b1 (PPAR\u03b1) by Environmental Chemicals in Relation to Their Toxicities", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Functional Activation of Peroxisome Proliferator-Activated Receptor \u03b1 (PPAR\u03b1) by Environmental Chemicals in Relation to Their Toxicities"}]}, "item_type_id": "9", "owner": "1", "path": ["499/508/509/516"], "permalink_uri": "https://doi.org/10.18999/nagjms.65.3-4.85", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2012-08-30"}, "publish_date": "2012-08-30", "publish_status": "0", "recid": "14830", "relation": {}, "relation_version_is_last": true, "title": ["Functional Activation of Peroxisome Proliferator-Activated Receptor \u03b1 (PPAR\u03b1) by Environmental Chemicals in Relation to Their Toxicities"], "weko_shared_id": null}