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Functional Activation of Peroxisome Proliferator-Activated Receptor α (PPARα) by Environmental Chemicals in Relation to Their Toxicities
https://doi.org/10.18999/nagjms.65.3-4.85
https://doi.org/10.18999/nagjms.65.3-4.8582ec26c5-9530-4788-9353-c0d5361148e9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
v65n34p85_94.pdf (60.8 kB)
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| アイテムタイプ | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-08-30 | |||||
| タイトル | ||||||
| タイトル | Functional Activation of Peroxisome Proliferator-Activated Receptor α (PPARα) by Environmental Chemicals in Relation to Their Toxicities | |||||
| 言語 | en | |||||
| 著者 |
NAKAJIMA, TAMIE
× NAKAJIMA, TAMIE× ICHIHARA, GAKU× KAMIJIMA, MICHIHIRO× ITOHARA, SEIICHIRO× AOYAMA, TOSHIFUMI |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | herbicides | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | organic solvents | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | peroxisome proliferator-activated receptor (PPARα) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | plasticizers plasticizers | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | transcriptional activation | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Peroxisome proliferator-activated receptor α (PPARα) may work in the processes of both physiological and toxicological response to various endogenous or exogenous substances. The literature on the study of functional activation of PPARα by environmental chemicals in relation to their toxicities were reviewed. Environmental chemicals that were found to induce peroxisomes (peroxisome proliferators) and to activate the function of PPARα included plasticizers, herbicides, and organic solvents that have carboxyl groups in their parent substances or their metabolites. Several studies have showed species differences in the constitutive expression of PPARα and activation of PPARα, which may result in species differences in the induction of transcription of the genes encoding several peroxisomal enzymes. Although much information has supported the view that PPARα is primarily involved in the hepatic carcinogenicity of peroxisome proliferators, conflicting evidence exists. Most of the peroxisome proliferators have been shown to induce reproductive and developmental disorders, which might, in part. be associated with the functional activation of PPARα. Few epidemiological studies on the effect of peroxisome proliferators on humans have been conducted. The effect of perfluorooctanoic acid on humans was evaluated from the aspect of lipid metabolism in one study, which concluded that there was no effect. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.65.3-4.85 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/6534/6534.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 65, 号 3-4, p. 85-94, 発行日 2002-11 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/16763 | |||||
| 識別子タイプ | HDL | |||||
