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アイテム
Stage-dependent changes in membrane currents in rats with monocrotaline-induced right ventricular hypertrophy
http://hdl.handle.net/2237/16800
http://hdl.handle.net/2237/16800903ade82-9674-4a7f-b3ef-b773e72b7f9e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
k4103.pdf (1.2 MB)
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| アイテムタイプ | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-09-25 | |||||
| タイトル | ||||||
| タイトル | Stage-dependent changes in membrane currents in rats with monocrotaline-induced right ventricular hypertrophy | |||||
| 言語 | en | |||||
| 著者 |
LEE, JONG-KOOK
× LEE, JONG-KOOK× KODAMA, ITSUO× HONJO, HARUO× ANDO, TAKAFUMI× KAMIYA, KAICHIRO× TOYAMA, JUNJI |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | action potential | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | transient outward current | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | calcium current | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Sequential changes in action potential configuration, 4-amino-pyridine-sensitive transient outward current (Ito), and L-type calcium current (ICa) in association with hypertrophy were investigated in ventricular myocytes from rats with monocrotaline (MCT)-induced pulmonary hypertension. The tissue weight ratio of right ventricle (RV) to left ventricle plus septum 14 and 28 days after a subcutaneous injection of MCT increased by 29.7 and 77.2%, respectively. Action potential duration (APD) of RV cells from MCT rats increased progressively, prolonged by 73.2 and 92.2% on days 14 and 28, respectively. The current density of Ito in RV cells from MCT rats on day 14 (32.5 +/- 4.5 pA/pF, n = 13) was significantly larger than in controls (26.8 +/- 4.5 pA/pF, n = 8; P < 0.05). On day 28, however, Ito density in MCT rats (15.3 +/- 4.6 pA/pF, n = 9) was significantly less than in controls (27.3 +/- 4.2 pA/pF, n = 10; P < 0.05). There were no differences in the voltage dependence of steady-state activation and inactivation of Ito between MCT and control rats. ICa density in MCT rats on day 14 (15.7 +/- 2.6 pA/pF, n = 10) was significantly larger than in controls (10.0 +/- 2.3 pA/pF, n = 10; P < 0.05), but there was no significant difference in Ito density between MCT rats (8.3 +/- 3.7 pA/pF, n = 10) and controls (11.6 +/- 3.0 pA/pF, n = 10) on day 28. These findings suggest that hypertrophy of mammalian hearts may cause stage-dependent changes in Ito and ICa density of ventricular myocytes. The APD prolongation in the early stage of hypertrophy may be caused mainly by an increase in ICa density, whereas the APD prolongation in the late stage may be ascribed to a reduction in Ito density. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成10年6月4日 李鍾國氏の博士論文として提出された | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | American Physiological Society | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_db06 | |||||
| タイプ | doctoral thesis | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://ajpheart.physiology.org/content/272/6/H2833.long | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0363-6135 | |||||
| 書誌情報 |
en : American journal of physiology - Heart and circulatory physiology 巻 272, 号 6, p. H2833-H2842, 発行日 1997-06 |
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| 学位名 | ||||||
| 学位名 | 博士(医学) | |||||
| 言語 | ja | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 13901 | |||||
| 学位授与機関名 | 名古屋大学 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | Nagoya University | |||||
| 言語 | en | |||||
| 学位授与年度 | ||||||
| 学位授与年度 | 1997 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 1997-06-01 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第4103号 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://ajpheart.physiology.org/content/272/6/H2833.long | |||||
| 識別子タイプ | URI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/16800 | |||||
| 識別子タイプ | HDL | |||||
