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  1. C100 医学部/医学系研究科
  2. C100d 学位論文
  3. 博士論文(医博・論医博)

A single intracoronary injection of midkine reduces ischemia/reperfusion injury in Swine hearts: a novel therapeutic approach for acute coronary syndrome

http://hdl.handle.net/2237/16801
http://hdl.handle.net/2237/16801
88e31c3c-1a61-4129-9c4c-df5fe5675239
名前 / ファイル ライセンス アクション
o6962.pdf o6962.pdf (1.1 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2012-09-26
タイトル
タイトル A single intracoronary injection of midkine reduces ischemia/reperfusion injury in Swine hearts: a novel therapeutic approach for acute coronary syndrome
言語 en
著者 Ishiguro, Hisaaki

× Ishiguro, Hisaaki

WEKO 45931

en Ishiguro, Hisaaki

Search repository
Horiba, Mitsuru

× Horiba, Mitsuru

WEKO 45932

en Horiba, Mitsuru

Search repository
Takenaka, Hiroharu

× Takenaka, Hiroharu

WEKO 45933

en Takenaka, Hiroharu

Search repository
Sumida, Arihiro

× Sumida, Arihiro

WEKO 45934

en Sumida, Arihiro

Search repository
Opthof, Tobias

× Opthof, Tobias

WEKO 45935

en Opthof, Tobias

Search repository
Ishiguro, S. Yuko

× Ishiguro, S. Yuko

WEKO 45936

en Ishiguro, S. Yuko

Search repository
Kadomatsu, Kenji

× Kadomatsu, Kenji

WEKO 45937

en Kadomatsu, Kenji

Search repository
Murohara, Toyoaki

× Murohara, Toyoaki

WEKO 45938

en Murohara, Toyoaki

Search repository
Kodama, Itsuo

× Kodama, Itsuo

WEKO 45939

en Kodama, Itsuo

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 midkine
キーワード
主題Scheme Other
主題 ischemia/reperfusion injury
キーワード
主題Scheme Other
主題 intracoronary injection
キーワード
主題Scheme Other
主題 acute coronary syndrome
抄録
内容記述 Several growth factors are effective for salvaging myocardium and limiting infarct size in experimental studies with small animals. Their benefit in large animals and feasibility in clinical practice remains to be elucidated. We investigated the cardioprotective effect of midkine (MK) in swine subjected to ischemia/reperfusion (I/R). I/R was created by left anterior descending coronary artery occlusion for 45 min using a percutaneous over-the-wire balloon catheter. MK protein was injected as a bolus through the catheter at the initiation of reperfusion [MK-treated (MKT) group]. Saline was injected in controls (CONT). Infarct size/area at risk (24 h after I/R) in MKT was almost five times smaller than in CONT. Echocardiography in MKT revealed a significantly higher percent wall thickening of the interventricular septum, a higher left ventricular (LV) fractional shortening, and a lower E/e(') (ratio of transmitral to annular flow) compared with CONT. LV catheterization in MKT showed a lower LV end-diastolic pressure, and a higher dP/dt(max) compared with CONT. Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end-labeling-positive myocytes and CD45-positive cell infiltration in the peri-infarct area were significantly less in MKT than in CONT. Here, we demonstrate that a single intracoronary injection of MK protein in swine hearts at the onset of reperfusion dramatically reduces infarct size and ameliorates systolic/diastolic LV function. This beneficial effect is associated with a reduction of apoptotic and inflammatory reactions. MK application during percutaneous coronary intervention may become a promising adjunctive therapy in acute coronary syndromes.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成24年2月29日 石黒久昌氏の博士論文として提出された
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Frontiers Media SA
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.3389/fphys.2011.00027
ISSN
収録物識別子タイプ EISSN
収録物識別子 1664-042X
書誌情報 en : Frontiers in Physiology

巻 2, 号 27, 発行日 2011-06
学位名
言語 ja
学位名 博士(医学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13901
言語 ja
学位授与機関名 名古屋大学
言語 en
学位授与機関名 Nagoya University
学位授与年度
学位授与年度 2011
学位授与年月日
学位授与年月日 2011-06-01
学位授与番号
学位授与番号 乙第6962号
著者版フラグ
値 publisher
URI
識別子 http://dx.doi.org/10.3389/fphys.2011.00027
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/16801
識別子タイプ HDL
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