{"_buckets": {"deposit": "9b0aad3d-aa3b-4cd8-9fbb-85d50ff34b60"}, "_deposit": {"id": "14868", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "14868"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00014868", "sets": ["1165"]}, "author_link": ["45940", "45941", "45942", "45943", "45944", "45945", "45946"], "item_12_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "583", "bibliographicPageStart": "577", "bibliographicVolumeNumber": "7", "bibliographic_titles": [{"bibliographic_title": "Heart Rhythm", "bibliographic_titleLang": "en"}]}]}, "item_12_date_granted_64": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2010-05-01"}]}, "item_12_degree_grantor_62": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_language": "ja", "subitem_degreegrantor_name": "名古屋大学"}, {"subitem_degreegrantor_language": "en", "subitem_degreegrantor_name": "Nagoya University"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "13901", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_12_degree_name_61": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)", "subitem_degreename_language": "ja"}]}, "item_12_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "BACKGROUND: There is evidence that verapamil promotes the persistence of paroxysmal atrial fibrillation (AF). Little is known about the underlying mechanisms. OBJECTIVE: The purpose of this study was to determine the effect of verapamil on dominant frequencies (DFs) in the pulmonary veins (PVs) and atria during paroxysmal AF with reference to its potential arrhythmogenicity. METHODS: Forty-three patients with paroxysmal AF were studied. Bipolar electrograms were recorded simultaneously during AF from the right atrial free wall (RAFW), coronary sinus (CS) and three PVs, or two PVs and the left atrial appendage (LAA). The DFs were obtained by fast Fourier transform analysis before and after infusion of verapamil (0.1 mg/kg, intravenously). RESULTS: At baseline, the maximum DF among the PVs (6.9 +/- 0.9 Hz) was significantly higher than the DF in the RAFW (6.2 +/- 0.7 Hz), CS (5.7 +/- 0.5 Hz), or LAA (5.9 +/- 0.7 Hz) (P\u003c.01); there was a substantial PV-to-atrial DF gradient (RAFW 0.7 +/- 0.9, CS 1.1 +/- 0.7, LAA 0.7 +/- 0.9 Hz). Verapamil increased the atrial DF to 6.9 +/- 0.8, 6.6 +/- 0.7, and 7.2 +/- 1.0 Hz in the RAFW, CS, and LAA, respectively (P\u003c.0001) but did not affect the maximum PV DF (7.1 +/- 0.7 Hz). The PV-to-atrial DF gradient was eliminated after verapamil (RAFW 0.2 +/- 0.8, CS 0.5 +/- 0.6, LAA -0.4 +/- 0.8 Hz; P\u003c.01 vs. baseline). CONCLUSION: Verapamil increases the activation frequency in the atria but not in the PVs, eliminating the PV-to-atrial DF gradient during paroxysmal AF.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_12_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成24年3月26日 櫛山泰規氏の博士論文として提出された", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_12_dissertation_number_65": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲第9559号"}]}, "item_12_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "DOI", "subitem_identifier_uri": "http://dx.doi.org/10.1016/j.hrthm.2010.01.008"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/16802"}]}, "item_12_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier", "subitem_publisher_language": "en"}]}, "item_12_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.hrthm.2010.01.008", "subitem_relation_type_select": "DOI"}}]}, "item_12_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This is the author\u0027s version of a work that was accepted for publication in Heart Rhythm. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Heart Rhythm. v.7, n.5, 2010, p.577–p.583, DOI: 10.1016/j.hrthm.2010.01.008", "subitem_rights_language": "en"}]}, "item_12_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_12_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1547-5271", "subitem_source_identifier_type": "PISSN"}]}, "item_12_text_63": {"attribute_name": "学位授与年度", "attribute_value_mlt": [{"subitem_text_value": "2010"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kushiyama, Yasunori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "45940", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Osaka, Toshiyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "45941", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yokoyama, Eriko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "45942", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hasebe, Hideyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "45943", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuroda, Yusuke", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "45944", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamiya, Kaichiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "45945", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kodama, Itsuo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "45946", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "k9559.pdf", "filesize": [{"value": "337.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 337000.0, "url": {"label": "k9559.pdf", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/14868/files/k9559.pdf"}, "version_id": "01d509ab-2387-4cc1-b2c6-1619f4565af4"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "paroxysmal atrial fibrillation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "verapamil", "subitem_subject_scheme": "Other"}, {"subitem_subject": "dominant frequency", "subitem_subject_scheme": "Other"}, {"subitem_subject": "pulmonary vein", "subitem_subject_scheme": "Other"}, {"subitem_subject": "atrium", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Verapamil Eliminates the Hierarchical Nature of Activation Frequencies from the Pulmonary Veins to the Atria during Paroxysmal Atrial Fibrillation", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Verapamil Eliminates the Hierarchical Nature of Activation Frequencies from the Pulmonary Veins to the Atria during Paroxysmal Atrial Fibrillation", "subitem_title_language": "en"}]}, "item_type_id": "12", "owner": "1", "path": ["1165"], "permalink_uri": "http://hdl.handle.net/2237/16802", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2012-09-26"}, "publish_date": "2012-09-26", "publish_status": "0", "recid": "14868", "relation": {}, "relation_version_is_last": true, "title": ["Verapamil Eliminates the Hierarchical Nature of Activation Frequencies from the Pulmonary Veins to the Atria during Paroxysmal Atrial Fibrillation"], "weko_shared_id": -1}