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Verapamil Eliminates the Hierarchical Nature of Activation Frequencies from the Pulmonary Veins to the Atria during Paroxysmal Atrial Fibrillation
http://hdl.handle.net/2237/16802
http://hdl.handle.net/2237/1680272ffe2e3-a007-4f98-aa83-85954072365e
| 名前 / ファイル | ライセンス | アクション |
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k9559.pdf (337.0 kB)
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| アイテムタイプ | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2012-09-26 | |||||
| タイトル | ||||||
| タイトル | Verapamil Eliminates the Hierarchical Nature of Activation Frequencies from the Pulmonary Veins to the Atria during Paroxysmal Atrial Fibrillation | |||||
| 言語 | en | |||||
| 著者 |
Kushiyama, Yasunori
× Kushiyama, Yasunori× Osaka, Toshiyuki× Yokoyama, Eriko× Hasebe, Hideyuki× Kuroda, Yusuke× Kamiya, Kaichiro× Kodama, Itsuo |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 権利情報 | This is the author's version of a work that was accepted for publication in Heart Rhythm. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Heart Rhythm. v.7, n.5, 2010, p.577–p.583, DOI: 10.1016/j.hrthm.2010.01.008 | |||||
| 言語 | en | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | paroxysmal atrial fibrillation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | verapamil | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | dominant frequency | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | pulmonary vein | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | atrium | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | BACKGROUND: There is evidence that verapamil promotes the persistence of paroxysmal atrial fibrillation (AF). Little is known about the underlying mechanisms. OBJECTIVE: The purpose of this study was to determine the effect of verapamil on dominant frequencies (DFs) in the pulmonary veins (PVs) and atria during paroxysmal AF with reference to its potential arrhythmogenicity. METHODS: Forty-three patients with paroxysmal AF were studied. Bipolar electrograms were recorded simultaneously during AF from the right atrial free wall (RAFW), coronary sinus (CS) and three PVs, or two PVs and the left atrial appendage (LAA). The DFs were obtained by fast Fourier transform analysis before and after infusion of verapamil (0.1 mg/kg, intravenously). RESULTS: At baseline, the maximum DF among the PVs (6.9 +/- 0.9 Hz) was significantly higher than the DF in the RAFW (6.2 +/- 0.7 Hz), CS (5.7 +/- 0.5 Hz), or LAA (5.9 +/- 0.7 Hz) (P<.01); there was a substantial PV-to-atrial DF gradient (RAFW 0.7 +/- 0.9, CS 1.1 +/- 0.7, LAA 0.7 +/- 0.9 Hz). Verapamil increased the atrial DF to 6.9 +/- 0.8, 6.6 +/- 0.7, and 7.2 +/- 1.0 Hz in the RAFW, CS, and LAA, respectively (P<.0001) but did not affect the maximum PV DF (7.1 +/- 0.7 Hz). The PV-to-atrial DF gradient was eliminated after verapamil (RAFW 0.2 +/- 0.8, CS 0.5 +/- 0.6, LAA -0.4 +/- 0.8 Hz; P<.01 vs. baseline). CONCLUSION: Verapamil increases the activation frequency in the atria but not in the PVs, eliminating the PV-to-atrial DF gradient during paroxysmal AF. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成24年3月26日 櫛山泰規氏の博士論文として提出された | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_db06 | |||||
| タイプ | doctoral thesis | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.hrthm.2010.01.008 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1547-5271 | |||||
| 書誌情報 |
en : Heart Rhythm 巻 7, 号 5, p. 577-583, 発行日 2010-05 |
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| 学位名 | ||||||
| 学位名 | 博士(医学) | |||||
| 言語 | ja | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 13901 | |||||
| 学位授与機関名 | 名古屋大学 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | Nagoya University | |||||
| 言語 | en | |||||
| 学位授与年度 | ||||||
| 学位授与年度 | 2010 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2010-05-01 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第9559号 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://dx.doi.org/10.1016/j.hrthm.2010.01.008 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/16802 | |||||
| 識別子タイプ | HDL | |||||
