{"_buckets": {"deposit": "9b0aad3d-aa3b-4cd8-9fbb-85d50ff34b60"}, "_deposit": {"id": "14868", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "14868"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00014868"}, "item_12_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "583", "bibliographicPageStart": "577", "bibliographicVolumeNumber": "7", "bibliographic_titles": [{"bibliographic_title": "Heart Rhythm"}]}]}, "item_12_date_granted_64": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5", "attribute_value_mlt": [{"subitem_dategranted": "2010-05-01"}]}, "item_12_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "BACKGROUND: There is evidence that verapamil promotes the persistence of paroxysmal atrial fibrillation (AF). Little is known about the underlying mechanisms. OBJECTIVE: The purpose of this study was to determine the effect of verapamil on dominant frequencies (DFs) in the pulmonary veins (PVs) and atria during paroxysmal AF with reference to its potential arrhythmogenicity. METHODS: Forty-three patients with paroxysmal AF were studied. Bipolar electrograms were recorded simultaneously during AF from the right atrial free wall (RAFW), coronary sinus (CS) and three PVs, or two PVs and the left atrial appendage (LAA). The DFs were obtained by fast Fourier transform analysis before and after infusion of verapamil (0.1 mg/kg, intravenously). RESULTS: At baseline, the maximum DF among the PVs (6.9 +/- 0.9 Hz) was significantly higher than the DF in the RAFW (6.2 +/- 0.7 Hz), CS (5.7 +/- 0.5 Hz), or LAA (5.9 +/- 0.7 Hz) (P\u003c.01); there was a substantial PV-to-atrial DF gradient (RAFW 0.7 +/- 0.9, CS 1.1 +/- 0.7, LAA 0.7 +/- 0.9 Hz). Verapamil increased the atrial DF to 6.9 +/- 0.8, 6.6 +/- 0.7, and 7.2 +/- 1.0 Hz in the RAFW, CS, and LAA, respectively (P\u003c.0001) but did not affect the maximum PV DF (7.1 +/- 0.7 Hz). The PV-to-atrial DF gradient was eliminated after verapamil (RAFW 0.2 +/- 0.8, CS 0.5 +/- 0.6, LAA -0.4 +/- 0.8 Hz; P\u003c.01 vs. baseline). CONCLUSION: Verapamil increases the activation frequency in the atria but not in the PVs, eliminating the PV-to-atrial DF gradient during paroxysmal AF.", "subitem_description_type": "Abstract"}]}, "item_12_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u540d\u53e4\u5c4b\u5927\u5b66\u535a\u58eb\u5b66\u4f4d\u8ad6\u6587 \u5b66\u4f4d\u306e\u7a2e\u985e : \u535a\u58eb(\u533b\u5b66)(\u8ab2\u7a0b) \u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5:\u5e73\u621024\u5e743\u670826\u65e5 \u6adb\u5c71\u6cf0\u898f\u6c0f\u306e\u535a\u58eb\u8ad6\u6587\u3068\u3057\u3066\u63d0\u51fa\u3055\u308c\u305f", "subitem_description_type": "Other"}]}, "item_12_dissertation_number_65": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7", "attribute_value_mlt": [{"subitem_dissertationnumber": "13901\u7532\u7b2c9559\u53f7"}]}, "item_12_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "DOI", "subitem_identifier_uri": "http://dx.doi.org/10.1016/j.hrthm.2010.01.008"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/16802"}]}, "item_12_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_12_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "This is the author\u0027s version of a work that was\naccepted for publication in Heart Rhythm. Changes resulting\nfrom the publishing process, such as peer review, editing,\ncorrections, structural formatting, and other quality control\nmechanisms, may not be reflected in this document. Changes\nmay have been made to this work since it was submitted for\npublication. A definitive version was subsequently published\nin Heart Rhythm. v.7, n.5, 2010, p.577\u2013p.583, DOI: 10.1016/j.hrthm.2010.01.008"}]}, "item_12_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_12_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1547-5271", "subitem_source_identifier_type": "ISSN"}]}, "item_12_text_63": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u5e74\u5ea6", "attribute_value_mlt": [{"subitem_text_value": "2010"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kushiyama, Yasunori"}], "nameIdentifiers": [{"nameIdentifier": "45940", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Osaka, Toshiyuki"}], "nameIdentifiers": [{"nameIdentifier": "45941", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yokoyama, Eriko"}], "nameIdentifiers": [{"nameIdentifier": "45942", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hasebe, Hideyuki"}], "nameIdentifiers": [{"nameIdentifier": "45943", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuroda, Yusuke"}], "nameIdentifiers": [{"nameIdentifier": "45944", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamiya, Kaichiro"}], "nameIdentifiers": [{"nameIdentifier": "45945", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kodama, Itsuo"}], "nameIdentifiers": [{"nameIdentifier": "45946", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "k9559.pdf", "filesize": [{"value": "337.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 337000.0, "url": {"label": "k9559.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/14868/files/k9559.pdf"}, "version_id": "01d509ab-2387-4cc1-b2c6-1619f4565af4"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "paroxysmal atrial fibrillation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "verapamil", "subitem_subject_scheme": "Other"}, {"subitem_subject": "dominant frequency", "subitem_subject_scheme": "Other"}, {"subitem_subject": "pulmonary vein", "subitem_subject_scheme": "Other"}, {"subitem_subject": "atrium", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Verapamil Eliminates the Hierarchical Nature of Activation Frequencies from the Pulmonary Veins to the Atria during Paroxysmal Atrial Fibrillation", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Verapamil Eliminates the Hierarchical Nature of Activation Frequencies from the Pulmonary Veins to the Atria during Paroxysmal Atrial Fibrillation"}]}, "item_type_id": "12", "owner": "1", "path": ["499/960/1165"], "permalink_uri": "http://hdl.handle.net/2237/16802", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2012-09-26"}, "publish_date": "2012-09-26", "publish_status": "0", "recid": "14868", "relation": {}, "relation_version_is_last": true, "title": ["Verapamil Eliminates the Hierarchical Nature of Activation Frequencies from the Pulmonary Veins to the Atria during Paroxysmal Atrial Fibrillation"], "weko_shared_id": null}