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  1. C100 医学部/医学系研究科
  2. C100d 学位論文
  3. 博士論文(医博・論医博)

Verapamil Eliminates the Hierarchical Nature of Activation Frequencies from the Pulmonary Veins to the Atria during Paroxysmal Atrial Fibrillation

http://hdl.handle.net/2237/16802
72ffe2e3-a007-4f98-aa83-85954072365e
名前 / ファイル ライセンス アクション
k9559.pdf k9559.pdf (337.0 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2012-09-26
タイトル
タイトル Verapamil Eliminates the Hierarchical Nature of Activation Frequencies from the Pulmonary Veins to the Atria during Paroxysmal Atrial Fibrillation
著者 Kushiyama, Yasunori

× Kushiyama, Yasunori

WEKO 45940

Kushiyama, Yasunori

Search repository
Osaka, Toshiyuki

× Osaka, Toshiyuki

WEKO 45941

Osaka, Toshiyuki

Search repository
Yokoyama, Eriko

× Yokoyama, Eriko

WEKO 45942

Yokoyama, Eriko

Search repository
Hasebe, Hideyuki

× Hasebe, Hideyuki

WEKO 45943

Hasebe, Hideyuki

Search repository
Kuroda, Yusuke

× Kuroda, Yusuke

WEKO 45944

Kuroda, Yusuke

Search repository
Kamiya, Kaichiro

× Kamiya, Kaichiro

WEKO 45945

Kamiya, Kaichiro

Search repository
Kodama, Itsuo

× Kodama, Itsuo

WEKO 45946

Kodama, Itsuo

Search repository
権利
権利情報 This is the author's version of a work that was
accepted for publication in Heart Rhythm. Changes resulting
from the publishing process, such as peer review, editing,
corrections, structural formatting, and other quality control
mechanisms, may not be reflected in this document. Changes
may have been made to this work since it was submitted for
publication. A definitive version was subsequently published
in Heart Rhythm. v.7, n.5, 2010, p.577–p.583, DOI: 10.1016/j.hrthm.2010.01.008
キーワード
主題Scheme Other
主題 paroxysmal atrial fibrillation
キーワード
主題Scheme Other
主題 verapamil
キーワード
主題Scheme Other
主題 dominant frequency
キーワード
主題Scheme Other
主題 pulmonary vein
キーワード
主題Scheme Other
主題 atrium
抄録
内容記述 BACKGROUND: There is evidence that verapamil promotes the persistence of paroxysmal atrial fibrillation (AF). Little is known about the underlying mechanisms. OBJECTIVE: The purpose of this study was to determine the effect of verapamil on dominant frequencies (DFs) in the pulmonary veins (PVs) and atria during paroxysmal AF with reference to its potential arrhythmogenicity. METHODS: Forty-three patients with paroxysmal AF were studied. Bipolar electrograms were recorded simultaneously during AF from the right atrial free wall (RAFW), coronary sinus (CS) and three PVs, or two PVs and the left atrial appendage (LAA). The DFs were obtained by fast Fourier transform analysis before and after infusion of verapamil (0.1 mg/kg, intravenously). RESULTS: At baseline, the maximum DF among the PVs (6.9 +/- 0.9 Hz) was significantly higher than the DF in the RAFW (6.2 +/- 0.7 Hz), CS (5.7 +/- 0.5 Hz), or LAA (5.9 +/- 0.7 Hz) (P<.01); there was a substantial PV-to-atrial DF gradient (RAFW 0.7 +/- 0.9, CS 1.1 +/- 0.7, LAA 0.7 +/- 0.9 Hz). Verapamil increased the atrial DF to 6.9 +/- 0.8, 6.6 +/- 0.7, and 7.2 +/- 1.0 Hz in the RAFW, CS, and LAA, respectively (P<.0001) but did not affect the maximum PV DF (7.1 +/- 0.7 Hz). The PV-to-atrial DF gradient was eliminated after verapamil (RAFW 0.2 +/- 0.8, CS 0.5 +/- 0.6, LAA -0.4 +/- 0.8 Hz; P<.01 vs. baseline). CONCLUSION: Verapamil increases the activation frequency in the atria but not in the PVs, eliminating the PV-to-atrial DF gradient during paroxysmal AF.
内容記述タイプ Abstract
内容記述
内容記述 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成24年3月26日 櫛山泰規氏の博士論文として提出された
内容記述タイプ Other
出版者
出版者 Elsevier
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
ISSN
収録物識別子タイプ ISSN
収録物識別子 1547-5271
書誌情報 Heart Rhythm

巻 7, 号 5, p. 577-583, 発行日 2010-05
学位授与年度
学位授与年度 2010
学位授与年月日
学位授与年月日 2010-05-01
学位授与番号
学位授与番号 13901甲第9559号
著者版フラグ
値 publisher
URI
識別子 http://dx.doi.org/10.1016/j.hrthm.2010.01.008
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/16802
識別子タイプ HDL
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