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  1. C100 医学部/医学系研究科
  2. C100d 学位論文
  3. 博士論文(医博・論医博)

Effect of Topical Application of Nitroglycerin on Cochlear Blood Flow

http://hdl.handle.net/2237/17092
http://hdl.handle.net/2237/17092
5a8c7920-d8f2-4c77-9fb2-4d0200708e9d
名前 / ファイル ライセンス アクション
o4770.pdf o4770.pdf (1.7 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2012-12-10
タイトル
タイトル Effect of Topical Application of Nitroglycerin on Cochlear Blood Flow
言語 en
その他のタイトル
その他のタイトル ニトログリセリン局所投与における蝸牛血流への影響
言語 ja
著者 ITO, ASAKO

× ITO, ASAKO

WEKO 46381

en ITO, ASAKO

Search repository
NAKASHIMA, TSUTOMU

× NAKASHIMA, TSUTOMU

WEKO 46382

en NAKASHIMA, TSUTOMU

Search repository
YANAGITA, NORIYUKI

× YANAGITA, NORIYUKI

WEKO 46383

en YANAGITA, NORIYUKI

Search repository
伊藤, 麻子

× 伊藤, 麻子

WEKO 46384

ja 伊藤, 麻子

Search repository
中島, 務

× 中島, 務

WEKO 46385

ja 中島, 務

Search repository
柳田, 則之

× 柳田, 則之

WEKO 46386

ja 柳田, 則之

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 NOTICE: This is the author's version of a work that was accepted for publication in American Journal of Otolaryngology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in American Journal of Otolaryngology. v.16, n.3, 1995, p.177-180, DOI: http://dx.doi.org/10.1016/0196-0709(95)90098-5
抄録
内容記述 Purpose: To investigate whether topical application of the vasodilator nitroglycerin would increase cochlear blood flow without adversely affecting inner ear function. Materials and Methods: The effect of topical application of nitroglycerin to the round window membrane on cochlear blood flow was measured in 33 guinea pigs with a laser Doppler flowmeter. Endocochlear potential, as an indicator of inner ear function, was recorded by a glass micro-electrode inserted through the round window membrane in a second series of 27 guinea pigs. Blood pressure was also monitored in both experiments. Results: Low doses (0.0001 to 1 wg) of nitroglycerin induced an increase in cochlear blood flow with no change in blood pressure. The cochlear blood flow was maximally increased by approximately 50%. A high dose (50 ILg) of nitroglycerin induced a significant decrease in blood pressure but did not significantly affect endocochlear potential. Conclusions: Topical application of nitroglycerin may be useful in increasing cochlear blood flow in various inner ear diseases.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 名古屋大学博士学位論文 学位の種類 : 博士(医学)(論文) 学位授与年月日:平成7年3月31日 伊藤麻子氏の博士論文として提出された
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/0196-0709(95)90098-5
ISSN
収録物識別子タイプ PISSN
収録物識別子 0196-0709
書誌情報 en : American Journal of Otolaryngology

巻 16, 号 3, p. 177-180, 発行日 1995-05
学位名
言語 ja
学位名 博士(医学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13901
言語 ja
学位授与機関名 名古屋大学
言語 en
学位授与機関名 Nagoya University
学位授与年度
学位授与年度 1995
学位授与年月日
学位授与年月日 1995-05-01
学位授与番号
学位授与番号 乙第4770号
著者版フラグ
値 publisher
URI
識別子 http://dx.doi.org/10.1016/0196-0709(95)90098-5
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/17092
識別子タイプ HDL
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