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Effect of Topical Application of Nitroglycerin on Cochlear Blood Flow
http://hdl.handle.net/2237/17092
http://hdl.handle.net/2237/170925a8c7920-d8f2-4c77-9fb2-4d0200708e9d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
o4770.pdf (1.7 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2012-12-10 | |||||
| タイトル | ||||||
| タイトル | Effect of Topical Application of Nitroglycerin on Cochlear Blood Flow | |||||
| 言語 | en | |||||
| その他のタイトル | ||||||
| その他のタイトル | ニトログリセリン局所投与における蝸牛血流への影響 | |||||
| 言語 | ja | |||||
| 著者 |
ITO, ASAKO
× ITO, ASAKO× NAKASHIMA, TSUTOMU× YANAGITA, NORIYUKI× 伊藤, 麻子× 中島, 務× 柳田, 則之 |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | NOTICE: This is the author's version of a work that was accepted for publication in American Journal of Otolaryngology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in American Journal of Otolaryngology. v.16, n.3, 1995, p.177-180, DOI: http://dx.doi.org/10.1016/0196-0709(95)90098-5 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: To investigate whether topical application of the vasodilator nitroglycerin would increase cochlear blood flow without adversely affecting inner ear function. Materials and Methods: The effect of topical application of nitroglycerin to the round window membrane on cochlear blood flow was measured in 33 guinea pigs with a laser Doppler flowmeter. Endocochlear potential, as an indicator of inner ear function, was recorded by a glass micro-electrode inserted through the round window membrane in a second series of 27 guinea pigs. Blood pressure was also monitored in both experiments. Results: Low doses (0.0001 to 1 wg) of nitroglycerin induced an increase in cochlear blood flow with no change in blood pressure. The cochlear blood flow was maximally increased by approximately 50%. A high dose (50 ILg) of nitroglycerin induced a significant decrease in blood pressure but did not significantly affect endocochlear potential. Conclusions: Topical application of nitroglycerin may be useful in increasing cochlear blood flow in various inner ear diseases. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 名古屋大学博士学位論文 学位の種類 : 博士(医学)(論文) 学位授与年月日:平成7年3月31日 伊藤麻子氏の博士論文として提出された | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/0196-0709(95)90098-5 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0196-0709 | |||||
| 書誌情報 |
en : American Journal of Otolaryngology 巻 16, 号 3, p. 177-180, 発行日 1995-05 |
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| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 13901 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 名古屋大学 | |||||
| 言語 | en | |||||
| 学位授与機関名 | Nagoya University | |||||
| 学位授与年度 | ||||||
| 値 | 1995 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 1995-05-01 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 乙第4770号 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://dx.doi.org/10.1016/0196-0709(95)90098-5 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/17092 | |||||
| 識別子タイプ | HDL | |||||
