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Epidermal Hyperplasia and Appendage Abnormalities in Mice Lacking CD109
http://hdl.handle.net/2237/17140
http://hdl.handle.net/2237/171408ef760a8-bc8f-46e8-b8f6-467999433a5f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
k9808.pdf (29.5 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-12-18 | |||||
| タイトル | ||||||
| タイトル | Epidermal Hyperplasia and Appendage Abnormalities in Mice Lacking CD109 | |||||
| 言語 | en | |||||
| 著者 |
Mii, Shinji
× Mii, Shinji× Murakumo, Yoshiki× Asai, Naoya× Jijiwa, Mayumi× Hagiwara, Sumitaka× Kato, Takuya× Asai, Masato× Enomoto, Atsushi× Ushida, Kaori× Sobue, Sayaka× Ichihara, Masatoshi× Takahashi, Masahide× 三井, 伸二 |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | NOTICE: This is the author's version of a work that was accepted for publication in The American Journal of Pathology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in The American Journal of Pathology. v.181, n.4, 2012, p.1180–1189, DOI: http://dx.doi.org/10.1016/j.ajpath.2012.06.021 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | CD109, a glycosylphosphatidylinositol-anchored glycoprotein, is highly expressed in several types of human cancer tissues, in particular, squamous cell carcinomas. In normal human tissues, human CD109 expression is limited to certain cell types including myoepithelial cells of the mammary, lacrimal, salivary, and bronchial glands and basal cells of the prostate and bronchial epithelium. Although CD109 has been reported to negatively regulate transforming growth factor-β signaling in keratinocytes in vitro, its physiologic role in vivo remains largely unknown. To investigate the function of CD109 in vivo, we generated CD109-deficient (CD109−/−) mice. Although CD109−/− mice were born normally, transient impairment of hair growth was observed. At histologic analysis, kinked hair shafts, ectatic hair follicles with an accumulation of sebum, and persistent hyperplasia of the epidermis and sebaceous glands were observed in CD109−/− mice. Immunohistochemical analysis revealed thickening of the basal and suprabasal layers in the epidermis of CD109−/− mice, which is where endogenous CD109 is expressed in wild-type mice. Although CD109 was reported to negatively regulate transforming growth factor-β signaling, no significant difference in levels of Smad2 phosphorylation was observed in the epidermis between wild-type and CD109−/− mice. Instead, Stat3 phosphorylation levels were significantly elevated in the epidermis of CD109−/− mice compared with wild-type mice. These results suggest that CD109 regulates differentiation of keratinocytes via a signaling pathway involving Stat3. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成24年7月31日 三井伸二氏の博士論文として提出された | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.ajpath.2012.06.021 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0002-9440 | |||||
| 書誌情報 |
en : The American Journal of Pathology 巻 181, 号 4, p. 1180-1189, 発行日 2012-10 |
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| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 13901 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 名古屋大学 | |||||
| 言語 | en | |||||
| 学位授与機関名 | Nagoya University | |||||
| 学位授与年度 | ||||||
| 値 | 2012 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2012-10-01 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第9808号 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://dx.doi.org/10.1016/j.ajpath.2012.06.021 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/17140 | |||||
| 識別子タイプ | HDL | |||||
