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  1. C100 医学部/医学系研究科
  2. C100d 学位論文
  3. 博士論文(医博・論医博)

Epidermal Hyperplasia and Appendage Abnormalities in Mice Lacking CD109

http://hdl.handle.net/2237/17140
http://hdl.handle.net/2237/17140
8ef760a8-bc8f-46e8-b8f6-467999433a5f
名前 / ファイル ライセンス アクション
k9808.pdf k9808.pdf (29.5 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2012-12-18
タイトル
タイトル Epidermal Hyperplasia and Appendage Abnormalities in Mice Lacking CD109
言語 en
著者 Mii, Shinji

× Mii, Shinji

WEKO 46422

en Mii, Shinji

Search repository
Murakumo, Yoshiki

× Murakumo, Yoshiki

WEKO 46423

en Murakumo, Yoshiki

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Asai, Naoya

× Asai, Naoya

WEKO 46424

en Asai, Naoya

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Jijiwa, Mayumi

× Jijiwa, Mayumi

WEKO 46425

en Jijiwa, Mayumi

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Hagiwara, Sumitaka

× Hagiwara, Sumitaka

WEKO 46426

en Hagiwara, Sumitaka

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Kato, Takuya

× Kato, Takuya

WEKO 46427

en Kato, Takuya

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Asai, Masato

× Asai, Masato

WEKO 46428

en Asai, Masato

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Enomoto, Atsushi

× Enomoto, Atsushi

WEKO 46429

en Enomoto, Atsushi

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Ushida, Kaori

× Ushida, Kaori

WEKO 46430

en Ushida, Kaori

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Sobue, Sayaka

× Sobue, Sayaka

WEKO 46431

en Sobue, Sayaka

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Ichihara, Masatoshi

× Ichihara, Masatoshi

WEKO 46432

en Ichihara, Masatoshi

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Takahashi, Masahide

× Takahashi, Masahide

WEKO 46433

en Takahashi, Masahide

Search repository
三井, 伸二

× 三井, 伸二

WEKO 46434

ja 三井, 伸二

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 NOTICE: This is the author's version of a work that was accepted for publication in The American Journal of Pathology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in The American Journal of Pathology. v.181, n.4, 2012, p.1180–1189, DOI: http://dx.doi.org/10.1016/j.ajpath.2012.06.021
抄録
内容記述 CD109, a glycosylphosphatidylinositol-anchored glycoprotein, is highly expressed in several types of human cancer tissues, in particular, squamous cell carcinomas. In normal human tissues, human CD109 expression is limited to certain cell types including myoepithelial cells of the mammary, lacrimal, salivary, and bronchial glands and basal cells of the prostate and bronchial epithelium. Although CD109 has been reported to negatively regulate transforming growth factor-β signaling in keratinocytes in vitro, its physiologic role in vivo remains largely unknown. To investigate the function of CD109 in vivo, we generated CD109-deficient (CD109−/−) mice. Although CD109−/− mice were born normally, transient impairment of hair growth was observed. At histologic analysis, kinked hair shafts, ectatic hair follicles with an accumulation of sebum, and persistent hyperplasia of the epidermis and sebaceous glands were observed in CD109−/− mice. Immunohistochemical analysis revealed thickening of the basal and suprabasal layers in the epidermis of CD109−/− mice, which is where endogenous CD109 is expressed in wild-type mice. Although CD109 was reported to negatively regulate transforming growth factor-β signaling, no significant difference in levels of Smad2 phosphorylation was observed in the epidermis between wild-type and CD109−/− mice. Instead, Stat3 phosphorylation levels were significantly elevated in the epidermis of CD109−/− mice compared with wild-type mice. These results suggest that CD109 regulates differentiation of keratinocytes via a signaling pathway involving Stat3.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成24年7月31日 三井伸二氏の博士論文として提出された
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.ajpath.2012.06.021
ISSN
収録物識別子タイプ PISSN
収録物識別子 0002-9440
書誌情報 en : The American Journal of Pathology

巻 181, 号 4, p. 1180-1189, 発行日 2012-10
学位名
言語 ja
学位名 博士(医学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13901
言語 ja
学位授与機関名 名古屋大学
言語 en
学位授与機関名 Nagoya University
学位授与年度
学位授与年度 2012
学位授与年月日
学位授与年月日 2012-10-01
学位授与番号
学位授与番号 甲第9808号
著者版フラグ
値 publisher
URI
識別子 http://dx.doi.org/10.1016/j.ajpath.2012.06.021
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/17140
識別子タイプ HDL
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