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Effect of Heterologous Transplantation of H4-II-E Rat Hepatoma Cells into the Cheek Pouch of Hydrocortisone Treated Hamsters
https://doi.org/10.18999/nagjms.36.1.49
https://doi.org/10.18999/nagjms.36.1.49c7faeea9-9513-494d-a0b7-4dfda66957bc
名前 / ファイル | ライセンス | アクション |
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v36n1p49_62.pdf (2.6 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2013-01-18 | |||||
タイトル | ||||||
タイトル | Effect of Heterologous Transplantation of H4-II-E Rat Hepatoma Cells into the Cheek Pouch of Hydrocortisone Treated Hamsters | |||||
言語 | en | |||||
著者 |
MURAGISHI, HIDEHIKO
× MURAGISHI, HIDEHIKO× BOTTOMLEY, RICHARD H. |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述 | A series of transplant·explant experiments using the H 4-II-E rat hepatoma cell line and golden hamsters have been carried out. Tissue culture cells implanted into the cheek pouch of hydrocortisone treated hamsters at a concentration of 106 cells per pouch produced tumors which histologically were typical hepatomas. Cells from these tumors were placed back into tissue culture and were transferred twice more into the cheek pouch of hydrocortisone treated hamsters and tissue culture. At each stage of selection, chromosome counts, karyotypes and histological and biological characteristics were determined. Cytogenetic studies revealed that the chromosome number in both tumors and explanted cultures shifted and became more selected with each succeeding in vivo and in vitro passage. The cells from the selected cultures had a much more homogeneous karyotype than cells with the same number of chromosomes from the original H 4-II-E culture. Tumors in the third selection had less hemorrhage and necrosis than in the first and second selections and were slower growing and showed lower transptantability than the original tumors produced by implantation of the H 4-II-E cells. These results indicate that transplantation of tissue culture cells into the cheek pouch of hamsters treated with hydrocortisone results in the selection of cells with a specific chromosomal constitution and altered transplantability and growth rate suggesting that the chromosomal makeup may determine the biological and immunological characteristics of the cell which allow it to grow under these conditions. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Nagoya University School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.36.1.49 | |||||
ID登録タイプ | JaLC | |||||
関連情報 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | URI | |||||
関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/361/361.html | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
en : Nagoya Journal of Medical Science 巻 36, 号 1, p. 49-62, 発行日 1973-11 |
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著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/17289 | |||||
識別子タイプ | HDL |