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Tissue culture cells implanted into the cheek pouch of hydrocortisone treated hamsters at a concentration of 106 cells per pouch produced tumors which histologically were typical hepatomas. Cells from these tumors were placed back into tissue culture and were transferred twice more into the cheek pouch of hydrocortisone treated hamsters and tissue culture. At each stage of selection, chromosome counts, karyotypes and histological and biological characteristics were determined. Cytogenetic studies revealed that the chromosome number in both tumors and explanted cultures shifted and became more selected with each succeeding in vivo and in vitro passage. The cells from the selected cultures had a much more homogeneous karyotype than cells with the same number of chromosomes from the original H 4-II-E culture. Tumors in the third selection had less hemorrhage and necrosis than in the first and second selections and were slower growing and showed lower transptantability than the original tumors produced by implantation of the H 4-II-E cells. These results indicate that transplantation of tissue culture cells into the cheek pouch of hamsters treated with hydrocortisone results in the selection of cells with a specific chromosomal constitution and altered transplantability and growth rate suggesting that the chromosomal makeup may determine the biological and immunological characteristics of the cell which allow it to grow under these conditions.", "subitem_description_type": "Abstract"}]}, "item_9_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "URI", "subitem_identifier_uri": "http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/361/361.html"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/17289"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.36.1.49", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University School of Medicine"}]}, "item_9_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_61": {"attribute_name": "ISSN(Online)", "attribute_value_mlt": [{"subitem_source_identifier": "2186-3326", "subitem_source_identifier_type": "ISSN"}]}, "item_9_source_id_7": {"attribute_name": "ISSN(print)", "attribute_value_mlt": [{"subitem_source_identifier": "0027-7622", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "MURAGISHI, HIDEHIKO"}], "nameIdentifiers": [{"nameIdentifier": "46612", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "BOTTOMLEY, RICHARD H."}], "nameIdentifiers": [{"nameIdentifier": "46613", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "v36n1p49_62.pdf", "filesize": [{"value": "2.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2600000.0, "url": {"label": "v36n1p49_62.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/15272/files/v36n1p49_62.pdf"}, "version_id": "38eb522c-0c1e-47ad-9a1c-097b0776fcbf"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Effect of Heterologous Transplantation of H4-II-E Rat Hepatoma Cells into the Cheek Pouch of Hydrocortisone Treated Hamsters", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Effect of Heterologous Transplantation of H4-II-E Rat Hepatoma Cells into the Cheek Pouch of Hydrocortisone Treated Hamsters"}]}, "item_type_id": "9", "owner": "1", "path": ["1434"], "permalink_uri": "https://doi.org/10.18999/nagjms.36.1.49", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-01-18"}, "publish_date": "2013-01-18", "publish_status": "0", "recid": "15272", "relation": {}, "relation_version_is_last": true, "title": ["Effect of Heterologous Transplantation of H4-II-E Rat Hepatoma Cells into the Cheek Pouch of Hydrocortisone Treated Hamsters"], "weko_shared_id": 3}
  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 36(1)

Effect of Heterologous Transplantation of H4-II-E Rat Hepatoma Cells into the Cheek Pouch of Hydrocortisone Treated Hamsters

https://doi.org/10.18999/nagjms.36.1.49
https://doi.org/10.18999/nagjms.36.1.49
c7faeea9-9513-494d-a0b7-4dfda66957bc
名前 / ファイル ライセンス アクション
v36n1p49_62.pdf v36n1p49_62.pdf (2.6 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-01-18
タイトル
タイトル Effect of Heterologous Transplantation of H4-II-E Rat Hepatoma Cells into the Cheek Pouch of Hydrocortisone Treated Hamsters
著者 MURAGISHI, HIDEHIKO

× MURAGISHI, HIDEHIKO

WEKO 46612

MURAGISHI, HIDEHIKO

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BOTTOMLEY, RICHARD H.

× BOTTOMLEY, RICHARD H.

WEKO 46613

BOTTOMLEY, RICHARD H.

Search repository
抄録
内容記述 A series of transplant·explant experiments using the H 4-II-E rat hepatoma cell line and golden hamsters have been carried out. Tissue culture cells implanted into the cheek pouch of hydrocortisone treated hamsters at a concentration of 106 cells per pouch produced tumors which histologically were typical hepatomas. Cells from these tumors were placed back into tissue culture and were transferred twice more into the cheek pouch of hydrocortisone treated hamsters and tissue culture. At each stage of selection, chromosome counts, karyotypes and histological and biological characteristics were determined. Cytogenetic studies revealed that the chromosome number in both tumors and explanted cultures shifted and became more selected with each succeeding in vivo and in vitro passage. The cells from the selected cultures had a much more homogeneous karyotype than cells with the same number of chromosomes from the original H 4-II-E culture. Tumors in the third selection had less hemorrhage and necrosis than in the first and second selections and were slower growing and showed lower transptantability than the original tumors produced by implantation of the H 4-II-E cells. These results indicate that transplantation of tissue culture cells into the cheek pouch of hamsters treated with hydrocortisone results in the selection of cells with a specific chromosomal constitution and altered transplantability and growth rate suggesting that the chromosomal makeup may determine the biological and immunological characteristics of the cell which allow it to grow under these conditions.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.36.1.49
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 36, 号 1, p. 49-62, 発行日 1973-11
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/361/361.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/17289
識別子タイプ HDL
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