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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 42(3-4)

Extraction of Leukemia Associated antigen (LAA) and Active Specific Immunization with LAA in Acute Leukemia

https://doi.org/10.18999/nagjms.42.3-4.55
https://doi.org/10.18999/nagjms.42.3-4.55
f8d91443-c03c-43bf-a2ea-2617651c64d6
名前 / ファイル ライセンス アクション
v42n34p55_68.pdf v42n34p55_68.pdf (953.3 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-01-23
タイトル
タイトル Extraction of Leukemia Associated antigen (LAA) and Active Specific Immunization with LAA in Acute Leukemia
著者 EZAKI, KOHJI

× EZAKI, KOHJI

WEKO 98682

EZAKI, KOHJI

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抄録
内容記述 Leukemia associated antigen (LAA) was prepared from leukemia cells, using hypotonic lysis and low frequency sonications, followed by diethylaminoethyl (DEAE) cellulose column chromatography. Four protein peaks were eluted by stepwise introduction of increased concentration of NaCl solutions. With running on polyacrylamide gel electrophoresis (PAGE), unique bands which were not present in extracts of remission bone marrow, appeared in eluates of higher mol NaCl solution. These eluates produced positive blastogenic response when incubated with autologous remission lymphocytes. Active specific immunization with pooled allogeneic LAA was performed in 14 adult AML patients in complete remission. Immunization was done weekly for 3 weeks and immunological studies (measurement of in vitro lymphocyte blastogenic responses and delayed hypersensitivity skin reactions) were done weekly for 5 weeks. Twelve out of 14 patients showed increased blastogenic responses to LAA after immunization, and 9 out of 10 studied showed increased blastogenic responses to irradiated autologous leukemia cells. Significant increases in blastogenic responses to both LAA and autologous leukemia cells were noticed on day 22 (p < 0.05). The increase of blastogenic responses seems to be higher among the patients whose length of remission was over 12 months at the time of immunization. There was no overall significant difference between blastogenic responses in autologous serum or pooled AB(+) serum. Increased skin test reactivity to LAA after immunization was seen in 7 out of 14 patients. Those patients with an initially weak reaction showed increased reactivity after immunization. There was no correlation between blastogenic responses and skin test reactivity.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.42.3-4.55
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/4234/4234.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 42, 号 3-4, p. 55-68, 発行日 1980-03
著者版フラグ
値 publisher
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