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Changes in Intracellular Taurine Content of Human Leukemic Cells
https://doi.org/10.18999/nagjms.45.3-4.89
https://doi.org/10.18999/nagjms.45.3-4.89c45b87f4-24f1-4cae-9bc7-bb2741405b7b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
v45n34p89_96.pdf (583.9 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-01-28 | |||||
| タイトル | ||||||
| タイトル | Changes in Intracellular Taurine Content of Human Leukemic Cells | |||||
| 言語 | en | |||||
| 著者 |
WAKAYAMA, KIKUKO
× WAKAYAMA, KIKUKO× BESA, EMMANUEL C.× BASKIN, STEVEN I. |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Taurine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Lymphocytes | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Granulocytes | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Leukemic cells | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Atypical leukemia | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Intracellular levels of the free amino acid taurine were measured in circulating granulocytes and mononuclear cells from 12 normal subjects and 27 patients with various types of leukemia, and in bone marrow cells from seven acute leukemias in blastic phase and 4 in remission. Leukemic cells have consistently lower taurine levels compared to normal lymphocytes and granulocytes. Although taurine levels in the circulating granulocytes from patients with acute and chronic leukemias were normal, they were significantly lower in the group of patients with atypical AML. The lowest taurine levels were observed in ihe mononuclear cells from patients with AML and ALL followed by those from patients with CML and CLL, and then those from patients with atypical AML. In AML patients the levels increased to normal values during clinical remission. The bone marrow mononuclear cells of AML in the blastic phase also had lower taurine levels compared to these in remission just same as peripheral blood cells do. These observations on the alteration in taurine content of both mononuclear cells in peripheral blood and bone marrow may be useful as a biochemical marker in diagnosis as well as for prediction of relapse and effectiveness of chemotherapy on patients with various types of leukemia. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.45.3-4.89 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/4534/4534.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 45, 号 3-4, p. 89-96, 発行日 1983-06 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/17413 | |||||
| 識別子タイプ | HDL | |||||
